Biological functions of macrophage-derived Wnt5a, and its roles in human diseases

Yue Shao, Qianqian Zheng, Wei Wang, Na Xin, Xiaowen Song and Chenghai Zhao _

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Oncotarget. 2016; 7:67674-67684. https://doi.org/10.18632/oncotarget.11874

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Yue Shao1, Qianqian Zheng1, Wei Wang1, Na Xin1, Xiaowen Song1 and Chenghai Zhao1

1 Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China

Correspondence to:

Chenghai Zhao, email:

Keywords: Wnt5a, β-catenin, macrophage, angiogenesis, lymphangiogenesis

Received: December 08, 2015 Accepted: August 27, 2016 Published: September 06, 2016


Wnt5a is implicated in development and tissue homeostasis by activating β-catenin-independent pathway. Excessive production of Wnt5a is related to some human diseases. Macrophage recruitment is a character of inflammation and cancer, therefore macrophage-derived Wnt5a is supposed to be a player in these conditions. Actually, macrophage-derived Wnt5a maintains macrophage immune function, stimulates pro-inflammatory cytokine release, and induces angiogenesis and lymphangiogenesis. Furthermore, macrophage-derived Wnt5a is involved in insulin resistance, atherosclerosis and cancer. These findings indicate that macrophage-derived Wnt5a may be a target in the treatment of these diseases. Notably, unlike macrophages, the exact role of macrophage-derived Wnt5a in bacterial infection remains largely unknown.

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