IκBζ: an emerging player in cancer

Marie Willems, Nadège Dubois, Lucia Musumeci, Vincent Bours and Pierre A. Robe _

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Oncotarget. 2016; 7:66310-66322. https://doi.org/10.18632/oncotarget.11624

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Marie Willems1, Nadège Dubois1, Lucia Musumeci1, Vincent Bours1 and Pierre A. Robe1,2

1 Department of Human Genetics and GIGA Research Center, University of Liège, Liege, Belgium

2 Department of Neurology and Neurosurgery, T&P Bohnenn Laboratory for Neuro-Oncology, Brain Center Rudolf Magnus, University Medical Center of Utrecht, Heidelberglaan, Utrecht, The Netherlands

Correspondence to:

Pierre A. Robe, email:

Keywords: IκBζ, nuclear IκB protein, NF-κB pathway, cancer, perspectives

Received: January 19, 2016 Accepted: August 23, 2016 Published: August 26, 2016


IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. Like its homolog Bcl3, IκBζ can regulate the transcription of a set of inflamatory genes through its association with the p50 or p52 subunits of NF-κB. Long studied as a key component of the immune response, IκBζ emerges as an important regulator of inflammation, cell proliferation and survival. As a result, growing evidence support the role of this transcription factor in the pathogenesis number of human hematological and solid malignancies.

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