Oncotarget

Research Papers:

The independent association of mean platelet volume with overall survival in multiple myeloma

Qiang Zhuang, Lina Xiang, Hanyan Xu, Fang Fang, Chongyun Xing, Bin Liang, Kang Yu and Jianhua Feng _

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Oncotarget. 2016; 7:62640-62646. https://doi.org/10.18632/oncotarget.11551

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Abstract

Qiang Zhuang1, Lina Xiang2, Hanyan Xu3, Fang Fang1, Chongyun Xing1, Bin Liang1, Kang Yu1, Jianhua Feng1,4

1Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China

2Department of Emergency Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China

3Department of Pneumology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China

4Department of Pediatric Hematology-Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China

Correspondence to:

Jianhua Feng, email: [email protected]

Keywords: multiple myeloma, mean platelet volume, prognosis, survival

Received: April 20, 2016     Accepted: August 13, 2016     Published: August 23, 2016

ABSTRACT

We retrospectively analyzed the association between mean platelet volume (MPV) and prognosis in 62 newly diagnosed multiple myeloma (MM) patients. The associations between MPV and clinical characteristics were assessed. The log-rank test and the Cox proportional hazards model were used to evaluate the effect of MPV on survival. A MPV value of 8.50 fl was considered to be the optimal cut-off value for prognosis. MPV was associated with IgA isotype (P=0.012), serum creatinine concentration > 176.8 μmol/L (P=0.025) and IgH rearrangement (P=0.008). The log-rank test demonstrated that patients with low MPV experienced a shorter overall survival (OS) (P=0.0397). The multivariate analysis demonstrated that low MPV was an independent prognostic factor for OS [hazard ratio (HR)=2.44, P=0.026]. Therefore, we demonstrated that low MPV predicted an unfavorable prognosis in patients with MM.


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