The independent association of mean platelet volume with overall survival in multiple myeloma
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Qiang Zhuang1, Lina Xiang2, Hanyan Xu3, Fang Fang1, Chongyun Xing1, Bin Liang1, Kang Yu1, Jianhua Feng1,4
1Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China
2Department of Emergency Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China
3Department of Pneumology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China
4Department of Pediatric Hematology-Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China
Jianhua Feng, email: [email protected]
Keywords: multiple myeloma, mean platelet volume, prognosis, survival
Received: April 20, 2016 Accepted: August 13, 2016 Published: August 23, 2016
We retrospectively analyzed the association between mean platelet volume (MPV) and prognosis in 62 newly diagnosed multiple myeloma (MM) patients. The associations between MPV and clinical characteristics were assessed. The log-rank test and the Cox proportional hazards model were used to evaluate the effect of MPV on survival. A MPV value of 8.50 fl was considered to be the optimal cut-off value for prognosis. MPV was associated with IgA isotype (P=0.012), serum creatinine concentration > 176.8 μmol/L (P=0.025) and IgH rearrangement (P=0.008). The log-rank test demonstrated that patients with low MPV experienced a shorter overall survival (OS) (P=0.0397). The multivariate analysis demonstrated that low MPV was an independent prognostic factor for OS [hazard ratio (HR)=2.44, P=0.026]. Therefore, we demonstrated that low MPV predicted an unfavorable prognosis in patients with MM.
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