Clinical Research Papers:

Clinical characteristics and prognostic factors of brain central neurocytoma

Yaqi Song, Xinle Kang, Gang Cao, Yongqiang Li, Xilei Zhou, Yusuo Tong and Wanwei Wang _

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Oncotarget. 2016; 7:76291-76297. https://doi.org/10.18632/oncotarget.11228

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Yaqi Song1,*, Xinle Kang2,*, Gang Cao3,*, Yongqiang Li4,*, Xilei Zhou1, Yusuo Tong1, Wanwei Wang1

1 Department of Radiation Oncology, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an, China

2 Department of Ophthalmology, Huai’an Second People’s Hospital, Xuzhou Medical College, Huai’an, China

3 Department of Internal Medicine, Huai’an Second People’s Hospital, Xuzhou Medical College, Huai’an, China

4 Department of Oncology, HangZhou Hospital of ZheJiang Provincial Corps of Chinese People’s Armed Police Force, HangZhou, China

* These authors have contributed equally to this manuscript

Correspondence to:

Wanwei Wang, email:

Yaqi Song, email:

Keywords: prognostic factors; central neurocytoma; tumor number; surgery; SEER program

Received: April 03, 2016 Accepted: July 23, 2016 Published: August 11, 2016


Background & Aims: This study is designed for the clinical characteristics and prognostic factors of central neurocytoma (CN).

Methods: CN patients from 2004 to 2012 were enrolled from the Surveillance Epidemiology and End Results (SEER) data. Clinical characteristics including age, sex, race, tumor size, tumor number, surgery, and radiation therapy were summarized. Univariate and multivariate analysis were performed to explore the prognostic factors of CN.

Results: CN tended to be borderline malignant and single lesion. Compared with other brain tumor (NCN), Patients with CN (CNs) were more likely to be female, young, and non-white race. Surgery was the primary treatment of CN. Univariate and Multivariate analysis indicated tumor number and surgery were both independent prognostic factors of CN (P < 0.05). Unifocal CNs had a lower mortality risk than multifocal ones (HR 0.167, 95% CI 0.052-0.537), surgery significantly reduced the death risk of CNs (HR 0.284, 95% CI 0.088-0.921).

Conclusions: CN tend to be borderline malignant, single lesion, operated on. Most CNs are female and younger. single lesion and surgery are the independent positive prognostic factors of CN.

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