Clinical Research Papers:

Predictive value of pedicle involvement with MRI in spine metastases

Wang Mi Liu, Rong Xing, Chong Bian, Yun Liang, Libo Jiang, Chen Qian and Jian Dong _

PDF  |  HTML  |  How to cite

Oncotarget. 2016; 7:62697-62705. https://doi.org/10.18632/oncotarget.10884

Metrics: PDF 1400 views  |   HTML 2961 views  |   ?  


Wang Mi Liu1,*, Rong Xing1,*, Chong Bian1, Yun Liang1, Libo Jiang1, Chen Qian1, Jian Dong1

1Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

*These authors have contributed equally to this work

Correspondence to:

Jian Dong, email: [email protected]

Keywords: MRI, spine metastases, pedicle

Received: February 19, 2016     Accepted: June 17, 2016     Published: July 28, 2016


Objectives: The study aimed to retrospectively evaluate the accuracy and value of magnetic resonance imaging (MRI) in predicting pedicle involvement for patients with spine metastases.

Methods: Forty-five patients with a vertebral metastasis encroaching at least one pedicle were studied using MRI before surgery and regularly after surgery. Patients were categorized on the basis of their numbers of pedicle involvement (Group 1: one pedicle was involved, n = 23; Group 2: two pedicles were involved, n = 22). The diagnostic accuracy was calculated, and comparisons of intraoperative blood loss and recurrence rate between the two groups were performed.

Results: The overall performance of MRI in predicting the pedicle involvement was as follows: accuracy, 94.4%; sensitivity, 95.5%; and specificity, 91.3%. Less intraoperative blood loss was observed for Group 1 compared with Group 2 (1,661 ± 672 ml and 2,173 ± 790 ml, respectively, P = 0.024). Tumor relapse occurred in 8.7% (2/23) of Group 1 and in 22.7% (5/22) of Group 2 with median recurrence free survival time 14 and 9 months, respectively.

Conclusions: MRI is a reliable approach to assess pedicle involvement. It has potential for use in the evaluation of the clinical characteristics of patients with spine metastases.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 10884