Oncotarget

Clinical Research Papers:

Predictive value of pedicle involvement with MRI in spine metastases

Wang Mi Liu, Rong Xing, Chong Bian, Yun Liang, Libo Jiang, Chen Qian and Jian Dong _

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Oncotarget. 2016; 7:62697-62705. https://doi.org/10.18632/oncotarget.10884

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Abstract

Wang Mi Liu1,*, Rong Xing1,*, Chong Bian1, Yun Liang1, Libo Jiang1, Chen Qian1, Jian Dong1

1Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

*These authors have contributed equally to this work

Correspondence to:

Jian Dong, email: [email protected]

Keywords: MRI, spine metastases, pedicle

Received: February 19, 2016     Accepted: June 17, 2016     Published: July 28, 2016

ABSTRACT

Objectives: The study aimed to retrospectively evaluate the accuracy and value of magnetic resonance imaging (MRI) in predicting pedicle involvement for patients with spine metastases.

Methods: Forty-five patients with a vertebral metastasis encroaching at least one pedicle were studied using MRI before surgery and regularly after surgery. Patients were categorized on the basis of their numbers of pedicle involvement (Group 1: one pedicle was involved, n = 23; Group 2: two pedicles were involved, n = 22). The diagnostic accuracy was calculated, and comparisons of intraoperative blood loss and recurrence rate between the two groups were performed.

Results: The overall performance of MRI in predicting the pedicle involvement was as follows: accuracy, 94.4%; sensitivity, 95.5%; and specificity, 91.3%. Less intraoperative blood loss was observed for Group 1 compared with Group 2 (1,661 ± 672 ml and 2,173 ± 790 ml, respectively, P = 0.024). Tumor relapse occurred in 8.7% (2/23) of Group 1 and in 22.7% (5/22) of Group 2 with median recurrence free survival time 14 and 9 months, respectively.

Conclusions: MRI is a reliable approach to assess pedicle involvement. It has potential for use in the evaluation of the clinical characteristics of patients with spine metastases.


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