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Carfilzomib/pomalidomide single-agent or in combination with other agents for the management of relapsed/refractory multiple myeloma: a meta-analysis of 37 trials

Yandun Zou, Xiaoyan Ma, Haiying Yu, Chunling Hu, Limei Fan and Xuehong Ran _

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Oncotarget. 2017; 8:39805-39817. https://doi.org/10.18632/oncotarget.10768

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Abstract

Yandun Zou1, Xiaoyan Ma2, Haiying Yu3, Chunling Hu1, Limei Fan1 and Xuehong Ran4

1 Internal Medicine, Guang Dong Women and Children Hospital, Guang Zhou, China

2 Department of I.C.U, Weifang People’s Hospital, Weifang, China

3 Department of Pediatrics, Weifang People’s Hospital, Weifang, China

4 Department of Hematology, Weifang People’s Hospital, Weifang, China

Correspondence to:

Xuehong Ran, email:

Keywords: pomalidomide, carfilzomib, lenalidomide, bortezomib, multiple myeloma

Received: April 25, 2016 Accepted: July 10, 2016 Published: July 21, 2016

Abstract

Purpose: The use of carfilzomib/pomalidomide single-agent or in combination with other agents in patients with refractory/relapsed multiple myeloma (RRMM) was not clearly clarified in clinical practice. We sought to compile the available clinical reports to better understand the efficacy and safety of carfilzomib (CFZ) and pomalidomide (POM).

Results: Based on our research criteria, we identified 37 prospective studies that evaluated 1160 patients. Analysis of subgroup differences between carfilzomib single-agent and CFZ/DEX dual combination showed significantly(P < 0.001, I2 = 96.3%), suggesting the overall response rate (ORR) of 66% attained from CFZ/DEX dual combination seemed to be higher than that of 28% from carfilzomib single-agent. And, the same trend favoring CFZ/DEX dual combination was found in ≥VGPR and CBR analysis. The ORR of 31% attained from POM/DEX dual combination was superior to that of 19% from pomalidomide single-agent(P < 0.001, I2 = 94.4%). And, the same trend favoring POM/DEX dual combination was found in ≥VGPR and CBR analysis. However, the ORR of 83% attained from POM/BOR/DEX triplet combination was superior to that of 31% from POM/DEX dual combination(P < 0.001, I2 = 99.1%). And, the same trend favoring POM/BOR/DEX triplet combination was found in ≥VGPR analysis.

Methods: We searched published reports including carfilzomib and (or) pomalidomide therapy for RRMM who had received bortezomib and (or) lenalidomide.

Conclusion: Pomalidomide/Carfilzomib plus dexamethasone seemed to attain a superior response rate compared with pomalidomide/carfilzomib single-agent. Furthermore, the combination of pomalidomide, bortezomib and dexamethasone resulted in a much higher response rate compared with pomalidomide plus dexamethasone regimen. These results needed more validation in future trials.


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