Oncotarget

Research Papers: Pathology:

Abnormal organization of white matter networks in patients with subjective cognitive decline and mild cognitive impairment

Xiao-Ni Wang, Yang Zeng, Guan-Qun Chen, Yi-He Zhang, Xuan-Yu Li, Xu-Yang Hao, Yang Yu, Meng Zhang, Can Sheng, Yu-Xia Li, Yu Sun, Hong-Yan Li, Yang Song, Kun-Cheng Li, Tian-Yi Yan, Xiao-Ying Tang and Ying Han _

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Oncotarget. 2016; 7:48953-48962. https://doi.org/10.18632/oncotarget.10601

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Abstract

Xiao-Ni Wang1,*, Yang Zeng2,*, Guan-Qun Chen1, Yi-He Zhang2, Xuan-Yu Li1, Xu-Yang Hao2, Yang Yu1, Meng Zhang2, Can Sheng1, Yu-Xia Li1, Yu Sun1, Hong-Yan Li1, Yang Song1, Kun-Cheng Li3, Tian-Yi Yan2, Xiao-Ying Tang2 and Ying Han1,4

1 Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China

2 School of Life Science, Beijing Institute of Technology, Beijing, China

3 Department of Radiology, XuanWu Hospital of Capital Medical University, Beijing, China

4 Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China

* These authors have contributed equally to this work

Correspondence to:

Ying Han, email:

Xiao-Ying Tang, email:

Tian-Yi Yan, email:

Keywords: subjective cognitive decline, amnestic mild cognitive impairment, network, white matter, diffusion tensor imaging, Pathology Section

Received: October 31, 2015 Accepted: June 29, 2016 Published: July 13, 2016

Abstract

Network analysis has been widely used in studying Alzheimer’s disease (AD). However, how the white matter network changes in cognitive impaired patients with subjective cognitive decline (SCD) (a symptom emerging during early stage of AD) and amnestic mild cognitive impairment (aMCI) (a pre-dementia stage of AD) is still unclear. Here, structural networks were constructed respectively based on FA and FN for 36 normal controls, 21 SCD patients, and 33 aMCI patients by diffusion tensor imaging and graph theory. Significantly lower efficiency was found in aMCI patients than normal controls (NC). Though not significant, the values in those with SCD were intermediate between aMCI and NC. In addition, our results showed significantly altered betweenness centrality located in right precuneus, calcarine, putamen, and left anterior cingulate in aMCI patients. Furthermore, association was found between network metrics and cognitive impairment. Our study suggests that the structural network properties might be preserved in SCD stage and disrupted in aMCI stage, which may provide novel insights into pathological mechanisms of AD.


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