Oncotarget

Clinical Research Papers:

Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy

Jeong Il Yu, Hyebin Lee, Hee Chul Park, Doo Ho Choi, Yoon-La Choi, In-Gu Do, Hee Cheol Kim, Woo Yong Lee, Seong Hyeon Yun, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Young Suk Park, Joon Oh Park, Seung Tae Kim and Won Park _

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Oncotarget. 2016; 7:62676-62686. https://doi.org/10.18632/oncotarget.10445

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Abstract

Jeong Il Yu1,*, Hyebin Lee5,*, Hee Chul Park1, Doo Ho Choi1, Yoon-La Choi2, In-Gu Do6, Hee Cheol Kim3, Woo Yong Lee3, Seong Hyeon Yun3, Yong Beom Cho3, Jung Wook Huh3, Yoon Ah Park4, Young Suk Park4, Joon Oh Park4, Seung Tae Kim4 and Won Park1

1 Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

2 Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

3 Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

4 Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

5 Department of Radiation Oncology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

6 Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

* These authors have contributed equally to this work as first authors

Correspondence to:

Won Park, email:

Keywords: rectal neoplasm, total mesorectal excision, radiotherapy, survivin, prognosis

Received: May 05, 2016 Accepted: June 18, 2016 Published: July 06, 2016

Abstract

Background & Aims: This study is designed to investigate the expression of survivin and p53 in human rectal cancer tissues and analyze associations between expression and clinical outcomes in terms of disease recurrence and survival duration.

Results: During follow-up (median 119.0, range 6.6 to 161.3 months), tumor recurrence was detected in 50 patients (43.1%), and local recurrence developed as a first failure site in 13 patients (11.2%). Positive immunostaining of nuclear and cytoplasmic survivin was observed in about one quarter of patients, and about half of all patients had positive staining for p53. Both survivin and p53 were significant prognostic factors of disease-free survival in the univariate analyses, but only survivin remained a significant prognostic factor in the multivariate analysis.

Methods: We performed a retrospective study with 116 locally advanced rectal cancer patients who underwent total mesorectal excision (TME) followed by postoperative concurrent chemo-radiation therapy (CCRT). Immunohistochemical staining was conducted using antibodies for survivin or p53, and their expression was analyzed using an individual score that combined the percentage of positive cells and staining intensity.

Conclusions: Overexpression of nuclear and cytoplasmic survivin in locally advanced rectal cancer patients was associated with a higher recurrence rate in rectal cancer patients treated with TME followed by postoperative CCRT.


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