Oncotarget

Research Papers:

Disruption of the EZH2/miRNA/β-catenin signaling suppresses aerobic glycolysis in glioma

Yingyi Wang, Min Wang, Wenjin Wei, Dongfeng Han, Xincheng Chen, Qi Hu, Tianfu Yu, Ning Liu, Yongping You and Junxia Zhang _

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Oncotarget. 2016; 7:49450-49458. https://doi.org/10.18632/oncotarget.10370

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Abstract

Yingyi Wang1,*, Min Wang2,*, Wenjin Wei1,*, Dongfeng Han1,*, Xincheng Chen1, Qi Hu1, Tianfu Yu1, Ning Liu1, Yongping You1, Junxia Zhang1

1Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

2Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

*These authors contributed equally to this work

Correspondence to:

Junxia Zhang, email: zjx2032@126.com

Keywords: EZH2, miRNA, β-catenin, aerobic glycolysis, glioma

Received: February 01, 2016     Accepted: June 12, 2016     Published: July 01, 2016

ABSTRACT

EZH2 is up-regulated in various cancer types, implicating its role in tumorigenesis. Our recent data have shown that repression of EZH2 inhibited glioma growth by inhibition β-catenin signaling. Here, we identified several miRNAs that were repressed by EZH2, which in turn regulate β-catenin expression by its 3′UTR, such as miR-1224-3p, miR-328 and miR-214. Further, EZH2 silenced miR-328 expression by binding to miR-328 promoter and promoting methylation of miR-328 promoter. Finally, miR-328 largely abrogated EZH2 effects on β-catenin expression and glucose metabolism in glioma cells. Taken together, we propose a model for a coordinated EZH2-β-catenin oncoprotein axis, and epigenetic link between histone modification and DNA methylation, mediated by EZH2-scilenced miRNAs.


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