Oncotarget

Reviews:

Cancer stem cell targeted therapy: progress amid controversies

Tao Wang, Sarah Shigdar, Michael P. Gantier, Yingchun Hou, Li Wang, Yong Li, Hadi Al Shamaileh, Wang Yin, Shu-Feng Zhou, Xinhan Zhao, _ Wei Duan

PDF  |  HTML  |  Order a Reprint

Oncotarget. 2015; 6:44191-44206. https://doi.org/10.18632/oncotarget.6176

Metrics: PDF 2491 views  |   HTML 2951 views  |   ?  


Abstract

Tao Wang1,2, Sarah Shigdar2, Michael P. Gantier3,4 , Yingchun Hou5, Li Wang6, Yong Li7, Hadi Al Shamaileh2, Wang Yin2, Shu-Feng Zhou8, Xinhan Zhao9 and Wei Duan2

1 School of Nursing, Zhengzhou University, Zhengzhou, China

2 School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia

3 Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia

4 Department of Molecular and Translational Science, Monash University, Clayton, Victoria, Australia

5 Co-Innovation Center for Qinba Region’s Sustainable Development, Shaanxi Normal University, Xi’an, China

6 Department of Gynecologic Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China

7 Cancer Care Centre, St George Hospital and St George Clinical School, University of New South Wales (UNSW), Kensington, Australia

8 Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA

9 Department of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an, China

Correspondence to:

Xinhan Zhao, email:

Wei Duan, email:

Keywords: cancer, cancer stem cell, anti-cancer treatment, cancer stem cell marker, cancer stem cell model

Received: August 12, 2015 Accepted: October 06, 2015 Published: October 19, 2015

Abstract

Although cancer stem cells have been well characterized in numerous malignancies, the fundamental characteristics of this group of cells, however, have been challenged by some recent observations: cancer stem cells may not necessary to be rare within tumors; cancer stem cells and non-cancer stem cells may undergo reversible phenotypic changes; and the cancer stem cells phenotype can vary substantially between patients. Here the current status and progresses of cancer stem cells theory is illustrated and via providing a panoramic view of cancer therapy, we addressed the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 6176