Oncotarget

Research Papers:

Long non-coding RNA ZFAS1 correlates with clinical progression and prognosis in cancer patients

Fangteng Liu, Hui Gao, Siyu Li, Xiaolin Ni and Zhengming Zhu _

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Oncotarget. 2017; 8:61561-61569. https://doi.org/10.18632/oncotarget.18633

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Abstract

Fangteng Liu1,*, Hui Gao1,*, Siyu Li2, Xiaolin Ni2 and Zhengming Zhu1

1Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, P. R. China

2The Second Clinical Medical College of Nanchang University, Nanchang 330000, Jiangxi Province, P. R. China

*These authors have contributed equally to this work

Correspondence to:

Zhengming Zhu, email: zzm8654@163.com

Keywords: ZFAS1, long non-coding RNA, cancer, prognosis, biomarker

Received: March 01, 2017     Accepted: May 31, 2017     Published: June 27, 2017

ABSTRACT

Dysregulation of long non-coding RNA zinc finger antisense 1 (ZFAS1) has been reported in many types of cancers. We performed a synthetic analysis to clarify its prognostic significance as a cancer molecular-marker. Several databases (including PubMed, Web of Science, Embase together with Wanfang and China National Knowledge Internet database) were retrieved to identify ZFAS1-related articles. A total of eight articles were included in this meta-analysis. Hazard ratios (HR) and 95% confidence intervals (CI) were applied to assess the association between ZFAS1 expression level and overall survival (OS). Odds ratios (OR) were calculated with RevMan 5.3 software to determine the relationship between ZFAS1 expression and clinicopathologic features. The pooled results of the meta-analysis indicated that high ZFAS1 expression level was positively correlated with poor OS (HR = 1.87, 95% CI: 1.38-2.36, p< 0.001) in human solid cancers. The statistical significance was also observed in subgroup analysis stratified by the cancer type, analysis method, sample size and follow-up time. Furthermore, the elevated ZFAS1 expression was significantly related to positive lymph node metastasis (OR = 4.18, 95% CI: 2.70-6.48, p< 0.001). The present results suggest that ZFAS1 might be served as a novel promising biomarker for prognosis in Chinese patients with solid cancers.


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