Oncotarget

Research Papers: Gerotarget (Focus on Aging):

CDKN2BAS polymorphisms are associated with coronary heart disease risk a Han Chinese population

Qingbin Zhao _, Shudan Liao, Huiyi Wei, Dandan Liu, Jingjie Li, Xiyang Zhang, Mengdan Yan and Tianbo Jin

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Oncotarget. 2016; 7:82046-82054. https://doi.org/10.18632/oncotarget.12575

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Abstract

Qingbin Zhao1, Shudan Liao2, Huiyi Wei1, Dandan Liu3, Jingjie Li4,5, Xiyang Zhang5, Mengdan Yan4,5 and Tianbo Jin4,5

1 Department of Geratology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

2 Department of Cardiology, Xi’an Center Hospital, Xi’an, Shaanxi, China

3 Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

4 Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi’an, Shaanxi, China

5 Xi’an Tiangen Precision Medical Institute, Xi’an, Shaanxi, China

Correspondence to:

Qingbin Zhao, email:

Keywords: coronary heart disease; single nucleotide polymorphisms; CDKN2BAS; case-control,Gerotarget

Received: September 01, 2016 Accepted: October 05, 2016 Published: October 11, 2016

Abstract

The goal of our study was to determine whether CDKN2BAS polymorphisms are associated with coronary heart disease (CHD) risk in a Han Chinese population. Eight SNPs were genotyped in 676 men and 465 women. We used χ2 tests and genetic model analyses to evaluate associations between the SNPs and CHD risk. We found that rs10757274 was associated with an increased risk of CHD in both men (allele G: Odds ratio [OR] = 1.30, 95% confidence interval [CI]: 1.05-1.61, P = 0.018; codominant model: P = 0.042; recessive model: OR = 1.70, 95% CI: 1.10-2.62, P = 0.016; log-additive model: OR = 1.34, 95% CI: 1.05-1.71, P = 0.019) and women (dominant model: OR = 2.26, 95% CI: 1.28-3.99, P = 0.004). In addition, rs7865618 was associated with an 8.10-fold increased risk of CHD in women under a recessive model (OR = 8.10, 95% CI: 1.74-37.68, P = 0.006). Interestingly, the haplotype AA (rs10757274 and rs1333042) of CDKN2BAS was associated with decreased the risk of CHD in men (OR = 0.72, 95% CI: 0.55 - 0.95, P = 0.022).


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