Oncotarget

Research Papers:

Predictive and prognostic value of preoperative serum tumor markers in resectable adenosqamous lung carcinoma

Qiongjie Zhi, Yuqian Wang, Xinyue Wang, Dongsheng Yue, Kai Li and Richeng Jiang _

PDF  |  HTML  |  Supplementary Files  |  How to cite  |  Order a Reprint

Oncotarget. 2016; 7:64798-64809. https://doi.org/10.18632/oncotarget.11703

Metrics: PDF 658 views  |   HTML 926 views  |   ?  


Abstract

Qiongjie Zhi1,2,3,*, Yuqian Wang1,2,3,*, Xinyue Wang1,2,3*, Dongsheng Yue1,2,4, Kai Li1,2,3 and Richeng Jiang1,2,3

1 Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin, PR China

2 Key Laboratory of Cancer Prevention and Therapy, Tianjin, PR China

3 Department of Thoracic Oncology, Tianjin Lung Cancer Center, Tianjin Cancer Institute & Hospital, Tianjin, PR China

4 Department of Lung Cancer, Tianjin Lung Cancer Center, Tianjin Cancer Institute & Hospital, Tianjin Medical University, Tianjin, PR China

* These authors have contributed equally to this work

Correspondence to:

Richeng Jiang, email:

Kai Li, email:

Keywords: tumor marker, TMI, adenosquamous lung carcinoma, prognostic factor, EGFR mutation

Received: July 18, 2016 Accepted: August 26, 2016 Published: August 30, 2016

Abstract

Background: Adenosquamous carcinoma is a rare and aggressive form of lung cancer. The prognostic and predictive value of preoperative serum tumor markers and frequency of EGFR mutations in adenosquamous lung carcinoma are unclear.

Methods: We retrospectively analyzed data and samples collected from 106 radically resected adenosquamous lung carcinoma patients with pathological stage I-IIIA between 2008 and 2013. Correlations between serum tumor marker levels and EGFR mutations as well as survival parameters were analyzed and prognostic factors were identified.

Results: Of the 106 adenosquamous lung carcinoma patients, 29 (27.4%) harbored EGFR mutations. By univariate analysis, advanced clinical stage (P = 0.009 for disease-free survival [DFS]; P = 0.046 for overall survival [OS]), larger tumor size (P = 0.001 for DFS; P = 0.002 for OS), regional lymph node metastasis (P = 0.024 for DFS; P = 0.030 for OS), higher NSE level (P = 0.002 for DFS; P < 0.001 for OS), and higher TMI (tumor marker index) (P = 0.009 for OS) were significantly correlated with a worse prognosis. By multivariate analysis, NSE (P = 0.014) was confirmed as independent predictor for DFS, while NSE (P = 0.001) and TMI (P = 0.038) were independent prognostic factors for OS.

Conclusion: Adenosquamous lung carcinoma is an aggressive malignancy with relatively high EGFR mutation frequency. Elevated preoperative NSE level and TMI are adverse predictive and prognostic indicators.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 11703