The Oncosearch | Oncotarget

Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21^WAF1 pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells Research Paper

Qiongshu Li, Guomu Liu, Hongyan Yuan, Juan Wang, Yingying Guo, Tanxiu Chen, Ruiping Zhai, Dan Shao, Weihua Ni, Guixiang Tai

Published Jan 20, 2015 · Vol. 6, No. 6 · pp. 4253-4265

Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype Research Paper

Jianxin Jiang, Chao Yu, Meiyuan Chen, Hao Zhang, Se Tian, Chengyi Sun

Published Dec 30, 2014 · Vol. 6, No. 5 · pp. 2767-2778

Aspartate Î²-hydroxylase expression promotes a malignant pancreatic cellular phenotype Research Paper

Xiaoqun Dong, Qiushi Lin, Arihiro Aihara, Yu Li, Chiung-Kuei Huang, Waihong Chung, Qi Tang, Xuesong Chen, Rolf Carlson, Christina Nadolny, Gregory Gabriel, Mark Olsen, Jack R. Wands

Published Nov 26, 2014 · Vol. 6, No. 2 · pp. 1231-1248

Intrinsic TGF-Î²2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells Research Paper

Takuya Nakamura, Satoru Shinriki, Hirofumi Jono, Jianying Guo, Mitsuharu Ueda, Mitsuhiro Hayashi, Satoshi Yamashita, Andries Zijlstra, Hideki Nakayama, Akimitsu Hiraki, Masanori Shinohara, Yukio Ando

Published Nov 25, 2014 · Vol. 6, No. 2 · pp. 1008-1019

RNA-seq analysis reveals significant effects of EGFR signalling on the secretome of mesenchymal stem cells Research Paper

Antonella De Luca, Cristin Roma, Marianna Gallo, Francesca Fenizia, Francesca Bergantino, Daniela Frezzetti, Susan Costantini, Nicola Normanno

Published Oct 29, 2014 · Vol. 5, No. 21 · pp. 10518-10528

Intratumoral administration of mRNA encoding a fusokine consisting of IFN-Î² and the ectodomain of the TGF-Î² receptor II potentiates antitumor immunity Research Paper

Kevin Van der Jeught, Patrick Tjok Joe, Lukasz Bialkowski, Carlo Heirman, Lidia Daszkiewicz, Therese Liechtenstein, David Escors, Kris Thielemans, Karine Breckpot

Published Sep 19, 2014 · Vol. 5, No. 20 · pp. 10100-10113

Melanoma-initiating cells exploit M2 macrophage TGFÎ² and arginase pathway for survival and proliferation Research Paper

Muly Tham, Kar Wai Tan, Jo Keeble, Xiaojie Wang, Sandra Hubert, Luke Barron, Nguan Soon Tan, Masashi Kato, Armelle Prevost-Blondel, Veronique Angeli, Jean-Pierre Abastado

Published Sep 16, 2014 · Vol. 5, No. 23 · pp. 12027-12042

Selective JAK2/ABL dual inhibition therapy effectively eliminates TKI-insensitive CML stem/progenitor cells Research Paper

Hanyang Lin, Min Chen, Katharina Rothe, Matthew V. Lorenzi, Adrian Woolfson, Xiaoyan Jiang

Published Aug 16, 2014 · Vol. 5, No. 18 · pp. 8637-8650

Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFÎ² receptor degradation Research Paper

Hsien-Yeh Hsu, Tung-Yi Lin, Yu-Chung Wu, Shu-Ming Tsao, Pai-An Hwang, Yu-Wei Shih, Jason Hsu

Published Aug 6, 2014 · Vol. 5, No. 17 · pp. 7870-7885

Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-ÎºB signaling Research Paper

Patty C.H. Cai, Lei Shi, Vincent W.S. Liu, Hermit W.M. Tang, Iris J. Liu, Thomas H.Y. Leung, Karen K.L. Chan, Judy W.P. Yam, Kwok-Ming Yao, Hextan Y.S. Ngan, David W. Chan

Published Jul 27, 2014 · Vol. 5, No. 17 · pp. 7549-7562

Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma Research Paper

Aparna Jayachandran, Matthew Anaka, Prashanth Prithviraj, Christopher Hudson, Sonja J. McKeown, Pu-Han Lo, Laura J. Vella, Colin R. Goding, Jonathan Cebon, Andreas Behren

Published Jul 8, 2014 · Vol. 5, No. 14 · pp. 5782-5797

Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-Î²/Smad signaling pathway Research Paper

Jiang Geng, Jie Fan, Qi Ouyang, Xiaopeng Zhang, Xiaolong Zhang, Juan Yu, Zude Xu, Qianyu Li, Xudong Yao, Xiuping Liu, Junhua Zheng

Published Jul 1, 2014 · Vol. 5, No. 14 · pp. 5700-5711

Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells Research Paper

GisÃ¨le Montavon, Nicolas Jauquier, AurÃ©lie Coulon, Michel Peuchmaur, Marjorie Flahaut, Katia Balmas Bourloud, Pu Yan, Olivier Delattre, Lukas Sommer, Jean-Marc Joseph, Isabelle Janoueix-Lerosey, Nicole Gross, Annick MÃ¼hlethaler-Mottet

Published May 27, 2014 · Vol. 5, No. 12 · pp. 4452-4466

CUL4A contributes to the biology of basal-like breast tumors through modulation of cell growth and antitumor immune response Research Paper

Laura P. Saucedo-Cuevas, Isabel Ruppen, Pilar XimÃ©nez-EmbÃºn, Samuel Domingo, Javier Gayarre, Javier MuÃ±oz, Jose M. Silva, MarÃa J. GarcÃa, Javier BenÃtez

Published Apr 18, 2014 · Vol. 5, No. 8 · pp. 2330-2343

Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

Hendrik Ungefroren, Susanne Sebens, Klaudia Giehl, Ole Helm, Stephanie Groth, Fred Faendrich, Christoph Roecken, Bence Sipos, Hendrik Lehnert, Frank Gieseler

Published Dec 23, 2013 · Vol. 5, No. 1 · pp. 277-290

Keywords: Rac1b, Rac1, Smad, TGF-beta1, pancreatic ductal adenocarcinoma, cell migration

Perspectives of TGF-Î² inhibition in pancreatic and hepatocellular carcinomas Review

Cindy Neuzillet, Armand de Gramont, AnnemilaÃ¯ Tijeras-Raballand, Louis de Mestier, JÃ©rÃ´me Cros, Sandrine Faivre, Eric Raymond

Published Dec 18, 2013 · Vol. 5, No. 1 · pp. 78-94

Keywords: SMAD, stellate cells, extracellular matrix, EMT, TGF-Î² inhibitors

Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis Research Paper

Akinori Morita, Shinya Ariyasu, Soichiro Ohya, Ippei Takahashi, Bing Wang, Kaoru Tanaka, Takatoshi Uchida, Haruna Okazaki, Kengo Hanaya, Atsushi Enomoto, Mitsuru Nenoi, Masahiko Ikekita, Shin Aoki, Yoshio Hosoi

Published Nov 24, 2013 · Vol. 4, No. 12 · pp. 2439-2450

Keywords: p53, zinc chelator, zinc binding site, radiation, apoptosis

Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity Review

Gerald J Prud'homme, Yelena Glinka

Published Sep 3, 2012 · Vol. 3, No. 9 · pp. 921-939

Keywords: angiogenesis, cancer stem cell, growth factor, neuropilin, semaphorin, TGF-beta, VEGF

A novel co-operative mechanism linking TGFÎ² and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cells Brief Reports

Andrew Chantry, Paul G Smith, Hideo Tanaka

Published May 24, 2012 · Vol. 3, No. 5 · pp. 518-524

Keywords: Transforming growth factor-Î², Smads, ubiquitin, c-cbl, Lyn, leukaemia

AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders Review

Sharmin Esmailzadeh, Xiaoyan Jiang

Published Dec 30, 2011 · Vol. 2, No. 12 · pp. 918-934

Keywords: AHI-1, oncogene, CML, CTCL, AHI-1-BCR-ABL-JAK2 interaction complex, tyrosine kinase inhibitors, leukemic stem cells, TKI resistance

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Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21^WAF1 pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells Research Paper

Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype Research Paper

Aspartate Î²-hydroxylase expression promotes a malignant pancreatic cellular phenotype Research Paper

Intrinsic TGF-Î²2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells Research Paper

RNA-seq analysis reveals significant effects of EGFR signalling on the secretome of mesenchymal stem cells Research Paper

Intratumoral administration of mRNA encoding a fusokine consisting of IFN-Î² and the ectodomain of the TGF-Î² receptor II potentiates antitumor immunity Research Paper

Melanoma-initiating cells exploit M2 macrophage TGFÎ² and arginase pathway for survival and proliferation Research Paper

Selective JAK2/ABL dual inhibition therapy effectively eliminates TKI-insensitive CML stem/progenitor cells Research Paper

Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFÎ² receptor degradation Research Paper

Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-ÎºB signaling Research Paper

Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma Research Paper

Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-Î²/Smad signaling pathway Research Paper

Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells Research Paper

CUL4A contributes to the biology of basal-like breast tumors through modulation of cell growth and antitumor immune response Research Paper

Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

Perspectives of TGF-Î² inhibition in pancreatic and hepatocellular carcinomas Review

Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis Research Paper

Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity Review

A novel co-operative mechanism linking TGFÎ² and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cells Brief Reports

AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21WAF1 pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells Research Paper

Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype Research Paper

Aspartate Î²-hydroxylase expression promotes a malignant pancreatic cellular phenotype Research Paper

Intrinsic TGF-Î²2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells Research Paper

RNA-seq analysis reveals significant effects of EGFR signalling on the secretome of mesenchymal stem cells Research Paper

Intratumoral administration of mRNA encoding a fusokine consisting of IFN-Î² and the ectodomain of the TGF-Î² receptor II potentiates antitumor immunity Research Paper

Melanoma-initiating cells exploit M2 macrophage TGFÎ² and arginase pathway for survival and proliferation Research Paper

Selective JAK2/ABL dual inhibition therapy effectively eliminates TKI-insensitive CML stem/progenitor cells Research Paper

Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFÎ² receptor degradation Research Paper

Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-ÎºB signaling Research Paper

Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma Research Paper

Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-Î²/Smad signaling pathway Research Paper

Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells Research Paper

CUL4A contributes to the biology of basal-like breast tumors through modulation of cell growth and antitumor immune response Research Paper

Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

Perspectives of TGF-Î² inhibition in pancreatic and hepatocellular carcinomas Review

Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis Research Paper

Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity Review

A novel co-operative mechanism linking TGFÎ² and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cells Brief Reports

AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders Review

Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21^WAF1 pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells Research Paper