The Oncosearch | Oncotarget

Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing Research Paper

Miguel Vizoso, Jacco van Rheenen

Published Jul 29, 2021 · Vol. 12, No. 17 · pp. 1651-1662

Keywords: targeted DNA methylation, CRISPR/Cas9-based system, IGFBP2, epithelial-to-mesenchymal transition

Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma Research Paper

Nesrin M. Hasan, Anup Sharma, Nensi M. Ruzgar, Hari Deshpande, Kelly Olino, Sajid Khan, Nita Ahuja

Published Jul 21, 2021 · Vol. 12, No. 16 · pp. 1566-1579

Keywords: leiomyosarcoma, epigenetics, DNA methylation, gene expression, uterine leiomyosarcoma

Ras-p53 genomic cooperativity as a model to investigate mechanisms of innate immune regulation in gastrointestinal cancers Research Perspective

Austin R. Dosch, Walid K. Chatila, Yuguang Ban, Anna Bianchi, Nilesh U. Deshpande, Iago De Castro Silva, Nipun B. Merchant, Jashodeep Datta

Published Jun 1, 2021 · Vol. 12, No. 20 · pp. 2104-2110

Keywords: Ras-p53 cooperativity, Ras, TP53, immune, gastrointestinal cancer

A novel E2F1-regulated lncRNA, LAPAS1, is required for S phase progression and cell proliferation Research Paper

Esther Baruch, Tali Nizri-Megnaji, Oron Berkowitz, Doron Ginsberg

Published May 7, 2021 · Vol. 12, No. 11 · pp. 1072-1082

Keywords: lncRNA, E2F, cell cycle, cell proliferation

Controlling for cellular heterogeneity using single-cell deconvolution of gene expression reveals novel markers of colorectal tumors exhibiting microsatellite instability Research Paper

Matthew A.M. Devall, Graham Casey

Published Mar 30, 2021 · Vol. 12, No. 8 · pp. 767-782

Keywords: colorectal cancer, single-cell deconvolution, microsatellite instability, RNA-sequencing, enteroendocrine

Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models Research Paper

Helena Degroote, Sander Lefere, Astrid Vandierendonck, Bart Vanderborght, Tim Meese, Filip Van Nieuwerburgh, Xavier Verhelst, Anja Geerts, Hans Van Vlierberghe, Lindsey Devisscher

Published Feb 20, 2021 · Vol. 12, No. 6 · pp. 562-577

Keywords: hepatocellular carcinoma, macrophage subsets, tumor microenvironment, tumor associated macrophages, inflammation

Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer Research Paper

Jared A. Sninsky, Kumar S. Bishnupuri, Iván González, Nikolaos A. Trikalinos, Ling Chen, Brian K. Dieckgraefe

Published Feb 8, 2021 · Vol. 12, No. 4 · pp. 278-291

Keywords: Reg4, CD44, CD44ICD, colorectal cancer

A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells Research Paper

Yuyuan Dai, Hiroyuki Kyoyama, Yi-Lin Yang, Yucheng Wang, Shu Liu, Yinghao Wang, Jian-Hua Mao, Zhidong Xu, Kazutsugu Uematsu, David M. Jablons, Liang You

Published Jan 15, 2021 · Vol. 12, No. 3 · pp. 173-184

Keywords: Homeodomain Interacting Protein Kinase 2 (HIPK2), non-small cell lung cancer (NSCLC), yes-associated protein (YAP), HIPK2 isoform, 4,5,6,7-tetrabromo-2-(1H-imidazol-2-yl)isoindoline-1,3-dione (TBID)

Differential gene expression in cisplatin-resistant and -sensitive testicular germ cell tumor cell lines Research Paper

Jan Roška, Lenka Wachsmannová, Lenka Hurbanová, Zuzana Šestáková, Thomas Mueller, Dana Jurkovičová, Miroslav Chovanec

Published Dec 5, 2020 · Vol. 11, No. 51 · pp. 4735-4753

Keywords: gene expression array, cisplatin, testicular germ cell tumors, prognostic biomarkers, pluripotency factors

Amalgamation of PI3K and EZH2 blockade synergistically regulates invasion and angiogenesis: combination therapy for glioblastoma multiforme Research Paper

Vishnu S. Mishra, Naveen Kumar, Masoom Raza, Seema Sehrawat

Published Dec 2, 2020 · Vol. 11, No. 51 · pp. 4754-4769

Keywords: precision neuroOncology, combination therapy, glioblastoma multiforme, pharmacological intervention, cytokine based proteomics

Novel 3-(3, 5-difluoro-4-hydroxyphenyl)-1-(naphthalen-2-yl) prop-2-en-1-one as a potent inhibitor of MAP-kinase in HeLa cell lines and anti-angiogenic activity is mediated by HIF-1α in EAC animal model Research Paper

Dileep Kumar M. Guruswamy, Kyathegowdana Doddi Srivinavasa Balaji, Kattepura Krishnappa Dharmappa, Shankar Jayarama

Published Nov 27, 2020 · Vol. 11, No. 50 · pp. 4661-4676

Keywords: novel chalcone, Bcl2, caspase 3, BAX, receptor tyrosine kinase inhibitor

The impact of the RASSF1C and PIWIL1 on DNA methylation: the identification of GMIP as a tumor suppressor Research Paper

Yousef G. Amaar, Mark E. Reeves

Published Oct 26, 2020 · Vol. 11, No. 45 · pp. 4082-4092

Keywords: lung cancer, RASSF1C, PIWIL1, DNA metylation,

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Marion Dubuissez, Sonia Paget, Souhila Abdelfettah, Nathalie Spruyt, Vanessa Dehennaut, Gaylor Boulay, Ingrid Loison, Clementine de Schutter, Brian R. Rood, Martine Duterque-Coquillaud, Xavier Leroy, Dominique Leprince

Published Oct 21, 2020 · Vol. 11, No. 45 · pp. 4138-4154

Keywords: HIC1, CXCL12, SDF1, α-SMA, Acta2

Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14 Research Paper

Francesca R. Dejure, Joachim Butzer, Ralph K. Lindemann, Balca R. Mardin

Published Sep 18, 2020 · Vol. 11, No. 48 · pp. 4490-4503

Keywords: SLC6A14, metabolic stress, transcriptional regulation, methionine, AMPK

ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest Research Paper

Luigi Scotto, Xavier J. Serrano, Kelly Zullo, Cristina Kinahan, Changchun Deng, Ahmed Sawas, Susan Bates, Owen A. O’Connor

Published Aug 18, 2020 · Vol. 11, No. 37 · pp. 3432-3442

Keywords: lymphoma, HDAC inhibitor, ATM inhibitor, p21, cell cycle

The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model Research Paper

Dimitra P. Vageli, David Kasle, Sotirios G. Doukas, Panagiotis G. Doukas, Clarence T. Sasaki

Published Aug 3, 2020 · Vol. 11, No. 35 · pp. 3303-3314

Keywords: NF-κB inhibition, BAY 11-7082, bile, laryngopharyngeal reflux, hypopharyngeal cancer

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

Annamil Alvarez-Trotta, Zhiqiang Wang, Elena Shersher, Bin Li, Jun Long, Ines Lohse, Claes Wahlestedt, Wael El-Rifai, David J. Robbins, Anthony J. Capobianco

Published Jul 28, 2020 · Vol. 11, No. 33 · pp. 3174-3187

Keywords: IBET-151, esophageal adenocarcinoma, GDC-0449 resistance, patient-derived xenografts, Hedgehog/GLI signaling pathway

Baicalin inhibits the TGF-β1/p-Smad3 pathway to suppress epithelial-mesenchymal transition-induced metastasis in breast cancer Research Paper

Ding-Kuo Liu, Hui-Feng Dong, Rui-Fen Liu, Xi-Long Xiao

Published Jul 4, 2020 · Vol. 11, No. 29 · pp. 2863-2872

Keywords: baicalin, TGF-β1, p-Smad3, epithelial-mesenchymal transition, breast cancer

Renal cell tumors convert natural killer cells to a proangiogenic phenotype Research Paper

Yue Guan, Christopher B. Chambers, Taylor Tabatabai, Ha Hatley, Kristin R. Delfino, Kathy Robinson, Shaheen R. Alanee, Sophia Ran, Donald S. Torry, Andrew Wilber

Published Jun 12, 2020 · Vol. 11, No. 26 · pp. 2571-2585

Keywords: kidney cancer, innate immunity, natural killer cells, immunosuppression, angiogenesis

Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1 Research Paper

Erik L. Brincks, James Adams, Lifu Wang, Benjamin Turner, Agnieszka Marcinowicz, Jiyuan Ke, Michael Essmann, Lucía M. Mautino, Clarissa Van Allen, Sanjeev Kumar, Nicholas Vahanian, Charles Link, Mario R. Mautino

Published Jun 9, 2020 · Vol. 11, No. 25 · pp. 2438-2461

Keywords: indoximod, IDO, TDO, AhR, mTORC1

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Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing Research Paper

Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma Research Paper

Ras-p53 genomic cooperativity as a model to investigate mechanisms of innate immune regulation in gastrointestinal cancers Research Perspective

A novel E2F1-regulated lncRNA, LAPAS1, is required for S phase progression and cell proliferation Research Paper

Controlling for cellular heterogeneity using single-cell deconvolution of gene expression reveals novel markers of colorectal tumors exhibiting microsatellite instability Research Paper

Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models Research Paper

Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer Research Paper

A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells Research Paper

Differential gene expression in cisplatin-resistant and -sensitive testicular germ cell tumor cell lines Research Paper

Amalgamation of PI3K and EZH2 blockade synergistically regulates invasion and angiogenesis: combination therapy for glioblastoma multiforme Research Paper

Novel 3-(3, 5-difluoro-4-hydroxyphenyl)-1-(naphthalen-2-yl) prop-2-en-1-one as a potent inhibitor of MAP-kinase in HeLa cell lines and anti-angiogenic activity is mediated by HIF-1α in EAC animal model Research Paper

The impact of the RASSF1C and PIWIL1 on DNA methylation: the identification of GMIP as a tumor suppressor Research Paper

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14 Research Paper

ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest Research Paper

The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model Research Paper

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

Baicalin inhibits the TGF-β1/p-Smad3 pathway to suppress epithelial-mesenchymal transition-induced metastasis in breast cancer Research Paper

Renal cell tumors convert natural killer cells to a proangiogenic phenotype Research Paper

Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1 Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing Research Paper

Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma Research Paper

Ras-p53 genomic cooperativity as a model to investigate mechanisms of innate immune regulation in gastrointestinal cancers Research Perspective

A novel E2F1-regulated lncRNA, LAPAS1, is required for S phase progression and cell proliferation Research Paper

Controlling for cellular heterogeneity using single-cell deconvolution of gene expression reveals novel markers of colorectal tumors exhibiting microsatellite instability Research Paper

Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models Research Paper

Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer Research Paper

A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells Research Paper

Differential gene expression in cisplatin-resistant and -sensitive testicular germ cell tumor cell lines Research Paper

Amalgamation of PI3K and EZH2 blockade synergistically regulates invasion and angiogenesis: combination therapy for glioblastoma multiforme Research Paper

Novel 3-(3, 5-difluoro-4-hydroxyphenyl)-1-(naphthalen-2-yl) prop-2-en-1-one as a potent inhibitor of MAP-kinase in HeLa cell lines and anti-angiogenic activity is mediated by HIF-1α in EAC animal model Research Paper

The impact of the RASSF1C and PIWIL1 on DNA methylation: the identification of GMIP as a tumor suppressor Research Paper

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14 Research Paper

ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest Research Paper

The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model Research Paper

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

Baicalin inhibits the TGF-β1/p-Smad3 pathway to suppress epithelial-mesenchymal transition-induced metastasis in breast cancer Research Paper

Renal cell tumors convert natural killer cells to a proangiogenic phenotype Research Paper

Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1 Research Paper