The Oncosearch | Oncotarget

The cancer testis antigens CABYR-a/b and CABYR-c are expressed in a subset of colorectal cancers and hold promise as targets for specific immunotherapy Research Paper

H.M.C. Shantha Kumara, Elie Sutton, Otavia L. Caballero, Tao Su, Xiaohong Yan, Aqeel Ahmed, Sonali A.C. Herath, Vesna Cekic, Linda Njoh, Daniel D. Kirchoff, Richard L. Whelan

Published Feb 9, 2021 · Vol. 12, No. 5 · pp. 412-421

Keywords: cancer testis antigens, colorectal cancer, CABYR a/b, c

Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer Research Paper

Jared A. Sninsky, Kumar S. Bishnupuri, Iván González, Nikolaos A. Trikalinos, Ling Chen, Brian K. Dieckgraefe

Published Feb 8, 2021 · Vol. 12, No. 4 · pp. 278-291

Keywords: Reg4, CD44, CD44ICD, colorectal cancer

Development of a ghrelin receptor inverse agonist for positron emission tomography Research Paper

Ralf Bergmann, Constance Chollet, Sylvia Els-Heindl, Martin Ullrich, Nicole Berndt, Jens Pietzsch, Domokos Máthé, Michael Bachmann, Annette G. Beck-Sickinger

Published Feb 7, 2021 · Vol. 12, No. 5 · pp. 450-474

Keywords: cancer, prostate cancer, growth hormone secretagogue receptor (GHS-R), small animal imaging, copper-64

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Bryony J. Telford, Sanaz Yahyanejad, Thijs de Gunst, Harm C. den Boer, Rogier M. Vos, Marieke Stegink, Marion T.J. van den Bosch, Mir Farshid Alemdehy, Laurens A.H. van Pinxteren, Roel Q.J. Schaapveld, Michel Janicot

Published Feb 7, 2021 · Vol. 12, No. 5 · pp. 422-439

Keywords: miR-193a-3p, microRNA mimic, microRNA delivery in vivo, pleiotropic mechanism of microRNA,

Extrahepatic cytochrome P450 epoxygenases: pathophysiology and clinical significance in human gastrointestinal cancers Review

Nataliya Pidkovka, Olena Rachkevych, Abbes Belkhiri

Published Feb 5, 2021 · Vol. 12, No. 4 · pp. 379-391

Keywords: cytochrome P450 epoxygenases, extrahepatic CYPs, gastrointestinal cancers, epoxyeicosatrienoic acids, arachidonic acid

Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration Research Paper

Thomas Perez, Raphaël Bergès, Hélène Maccario, Sarah Oddoux, Stéphane Honoré

Published Feb 5, 2021 · Vol. 12, No. 4 · pp. 304-315

Keywords: vorinostat, glioblastoma, EB1, microtubule, tubulin

Mutational profile of skin lesions in hepatocellular carcinoma patients under tyrosine kinase inhibition: a repercussion of a wide-spectrum activity Research Paper

Leonardo G. da Fonseca, Carla Fuster-Anglada, Cristina Carrera, Cristina Millán, Esther Samper, Victor Sapena, Álvaro Díaz-González, Marco Sanduzzi-Zamparelli, Cassia Leal, Alejandro Forner, Jordi Bruix, Maria Reig, Loreto Boix, Alba Díaz

Published Feb 5, 2021 · Vol. 12, No. 5 · pp. 440-449

Keywords: hepatocellular carcinoma, tyrosine kinase inhibitors, treatment adverse events, skin lesions, molecular profiling

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper

Juan Pablo Cerapio, Agnès Marchio, Luis Cano, Ignacio López, Jean-Jacques Fournié, Béatrice Régnault, Sandro Casavilca-Zambrano, Eloy Ruiz, Anne Dejean, Stéphane Bertani, Pascal Pineau

Published Feb 3, 2021 · Vol. 12, No. 5 · pp. 475-492

Keywords: hepatitis B virus, indigenous people, integrative genomics, liver cancer

Quantitative proteome profiling stratifies fibroepithelial lesions of the breast Research Paper

Aviral Kumar, David S. Nayakanti, Kiran K. Mangalaparthi, Veena Gopinath, Nandyala Venkat Narsimha Reddy, Krishna Govindan, Geeta Voolapalli, Prashant Kumar, Lekha Dinesh Kumar

Published Feb 3, 2021 · Vol. 12, No. 5 · pp. 507-518

Keywords: breast tumors, fibroepithelial lesions, phyllodes, iTRAQ, quantitative proteomics

Fine–mapping of two differentiated thyroid carcinoma susceptibility loci at 2q35 and 8p12 in Europeans, Melanesians and Polynesians Research Paper

Julie Guibon, Pierre-Emmanuel Sugier, Om Kulkarni, Mojgan Karimi, Delphine Bacq-Daian, Céline Besse, Anne Boland, Elisabeth Adjadj, Frédérique Rachédi, Carole Rubino, Constance Xhaard, Claire Mulot, Pierre Laurent-Puig, Anne-Valérie Guizard, Claire Schvartz, Rosa Maria Ortiz, Yan Ren, Evgenia Ostroumova, Jean-François Deleuze, Marie-Christine Boutron-Ruault, Ausrele Kesminiene, Florent De Vathaire, Pascal Guénel, Fabienne Lesueur, Thérèse Truong

Published Feb 3, 2021 · Vol. 12, No. 5 · pp. 493-506

Keywords: thyroid cancer, cancer genetics, case-control study, fine-mapping study, single nucleotide polymorphism

GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth Correction

Junghui Koo, Xuerong Wang, Taofeek K. Owonikoko, Suresh S. Ramalingam, Fadlo R. Khuri, Shi-Yong Sun

Published Feb 2, 2021 · Vol. 12, No. 3 · pp. 251-252

Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors Research Paper

Naoko Takebe, Geraldine O'Sullivan Coyne, Shivaani Kummar, Jerry Collins, Joel M. Reid, Richard Piekarz, Nancy Moore, Lamin Juwara, Barry C. Johnson, Rachel Bishop, Frank I. Lin, Esther Mena, Peter L. Choyke, M. Liza Lindenberg, Larry V. Rubinstein, Cecilia Monge Bonilla, Matthew P. Goetz, Matthew M. Ames, Renee M. McGovern, Howard Streicher, Joseph M. Covey, James H. Doroshow, Alice P. Chen

Published Feb 1, 2021 · Vol. 12, No. 4 · pp. 268-277

Keywords: Z-endoxifen, phase 1, tamoxifen, pharmacokinetics

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Ali H. Zaidi, Ronan J. Kelly, Anastasia Gorbunova, Ashten N. Omstead, Madison S. Salvitti, Ping Zheng, Juliann E. Kosovec, Soyoung Lee, Shahin Ayazi, Laila Babar, Gene G. Finley, Ajay Goel, Blair A. Jobe

Published Feb 1, 2021 · Vol. 12, No. 4 · pp. 292-303

Keywords: esophageal adenocarcinoma, STING, PD-L1, CD8+ T-cells, IFNβ

Correction: Cbl-b inhibits P-gp transporter function by preventing its translocation into caveolae in multiple drug-resistant gastric and breast cancers Correction

Ye Zhang, Xiujuan Qu, Yuee Teng, Zhi Li, Ling Xu, Jing Liu, Yanju Ma, Yibo Fan, Ce Li, Shizhou Liu, Zhenning Wang, Xuejun Hu, Jingdong Zhang, Yunpeng Liu

Published Jan 30, 2021 · Vol. 12, No. 16 · pp. 1634-1637

STAT3 induces the expression of GLI1 in chronic lymphocytic leukemia cells Research Paper

Uri Rozovski, David M. Harris, Ping Li, Zhiming Liu, Preetesh Jain, Taghi Manshouri, Ivo Veletic, Alessandra Ferrajoli, Prithviraj Bose, Phillip Thompson, Nitin Jain, Srdan Verstovsek, William Wierda, Michael J. Keating, Zeev Estrov

Published Jan 30, 2021 · Vol. 12, No. 5 · pp. 401-411

Keywords: CLL, STAT3, GLI1, apoptosis, transcription

Quercetin shortened survival of radio-resistant B-1 cells in vitro and in vivo by restoring miR15a/16 expression Research Paper

Yasmim Alefe Leuzzi Ramos, Olivia Fonseca Souza, Marilia Campos Tavares Novo, Caroline Ferreira Cunha Guimarães, Ana Flavia Popi

Published Jan 29, 2021 · Vol. 12, No. 4 · pp. 355-365

Keywords: B-1 cells, chronic lymphocytic leukemia, quercetin, Wnt, miRNA

The goal of geroscience is life extension Research Perspective

Mikhail V. Blagosklonny

Published Jan 28, 2021 · Vol. 12, No. 3 · pp. 131-144

Keywords: aging, longevity, rapamycin, mTOR, metformin

The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma Research Paper

Kazunori Tokuda, Yuji Morine, Katsuki Miyazaki, Shinichiro Yamada, Yu Saito, Masaaki Nishi, Takuya Tokunaga, Tetsuya Ikemoto, Satoru Imura, Mitsuo Shimada

Published Jan 27, 2021 · Vol. 12, No. 4 · pp. 333-343

Keywords: hepatocellular carcinoma, osteopontin, cancer associated fibroblast, tumor associated macrophage, tumor microenvironment

Cancer stem cells and macrophages: molecular connections and future perspectives against cancer Review

Beatrice Aramini, Valentina Masciale, Giulia Grisendi, Federico Banchelli, Roberto D’Amico, Antonino Maiorana, Uliano Morandi, Massimo Dominici, Khawaja Husnain Haider

Published Jan 27, 2021 · Vol. 12, No. 3 · pp. 230-250

Keywords: cancer stem cells, macrophages, future perspectives, cancer, target treatments

High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma Research Paper

Eric Russ, Krithika Bhuvaneshwar, Guisong Wang, Benjamin Jin, Michele M. Gage, Subha Madhavan, Yuriy Gusev, Geeta Upadhyay

Published Jan 26, 2021 · Vol. 12, No. 3 · pp. 145-159

Keywords: LY6 genes, pancreatic cancer, immune cells, survival outcome

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The cancer testis antigens CABYR-a/b and CABYR-c are expressed in a subset of colorectal cancers and hold promise as targets for specific immunotherapy Research Paper

Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer Research Paper

Development of a ghrelin receptor inverse agonist for positron emission tomography Research Paper

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Extrahepatic cytochrome P450 epoxygenases: pathophysiology and clinical significance in human gastrointestinal cancers Review

Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration Research Paper

Mutational profile of skin lesions in hepatocellular carcinoma patients under tyrosine kinase inhibition: a repercussion of a wide-spectrum activity Research Paper

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper

Quantitative proteome profiling stratifies fibroepithelial lesions of the breast Research Paper

Fine–mapping of two differentiated thyroid carcinoma susceptibility loci at 2q35 and 8p12 in Europeans, Melanesians and Polynesians Research Paper

GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth Correction

Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors Research Paper

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Correction: Cbl-b inhibits P-gp transporter function by preventing its translocation into caveolae in multiple drug-resistant gastric and breast cancers Correction

STAT3 induces the expression of GLI1 in chronic lymphocytic leukemia cells Research Paper

Quercetin shortened survival of radio-resistant B-1 cells in vitro and in vivo by restoring miR15a/16 expression Research Paper

The goal of geroscience is life extension Research Perspective

The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma Research Paper

Cancer stem cells and macrophages: molecular connections and future perspectives against cancer Review

High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

The cancer testis antigens CABYR-a/b and CABYR-c are expressed in a subset of colorectal cancers and hold promise as targets for specific immunotherapy Research Paper

Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer Research Paper

Development of a ghrelin receptor inverse agonist for positron emission tomography Research Paper

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Extrahepatic cytochrome P450 epoxygenases: pathophysiology and clinical significance in human gastrointestinal cancers Review

Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration Research Paper

Mutational profile of skin lesions in hepatocellular carcinoma patients under tyrosine kinase inhibition: a repercussion of a wide-spectrum activity Research Paper

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper

Quantitative proteome profiling stratifies fibroepithelial lesions of the breast Research Paper

Fine–mapping of two differentiated thyroid carcinoma susceptibility loci at 2q35 and 8p12 in Europeans, Melanesians and Polynesians Research Paper

GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth Correction

Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors Research Paper

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Correction: Cbl-b inhibits P-gp transporter function by preventing its translocation into caveolae in multiple drug-resistant gastric and breast cancers Correction

STAT3 induces the expression of GLI1 in chronic lymphocytic leukemia cells Research Paper

Quercetin shortened survival of radio-resistant B-1 cells in vitro and in vivo by restoring miR15a/16 expression Research Paper

The goal of geroscience is life extension Research Perspective

The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma Research Paper

Cancer stem cells and macrophages: molecular connections and future perspectives against cancer Review

High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma Research Paper