The Oncosearch | Oncotarget

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition Priority Research Paper

Catherine Wilson, Katrina Nicholes, Daisy Bustos, Eva Lin, Qinghua Song, Jean-Philippe Stephan, Donald S. Kirkpatrick, Jeff Settleman

Published Aug 27, 2014 · Vol. 5, No. 17 · pp. 7328-7341

Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia Research Paper

Shachar Raz, Michal Stark, Yehuda G. Assaraf

Published Aug 27, 2014 · Vol. 5, No. 19 · pp. 9183-9198

p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-ÎºB pathway Research Paper

Nikhil Tyagi, Arun Bhardwaj, Ajay P. Singh, Steven McClellan, James E. Carter, Seema Singh

Published Aug 27, 2014 · Vol. 5, No. 18 · pp. 8778-8789

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms Research Paper

Xin Chen, Xianping Shi, Chong Zhao, Xiaofen Li, Xiaoying Lan, Shouting Liu, Hongbiao Huang, Ningning Liu, Siyan Liao, Dan Zang, Wenbin Song, Quentin Liu, Bing Z. Carter, Ping Q. Dou, Xuejun Wang, Jinbao Liu

Published Aug 22, 2014 · Vol. 5, No. 19 · pp. 9118-9132

Keywords: Auranofin, proteasome, chronic myelogenous leukemia, imatinib resistance, Bcr-Abl

MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells Priority Research Paper

Akriti Kharbanda, Hasan Rajabi, Caining Jin, Maroof Alam, Kwok-Kin Wong, Donald Kufe

Published Aug 22, 2014 · Vol. 5, No. 19 · pp. 8893-8905

Keywords: KRAS, NSCLC, MUC1-C, AKT, ZEB1, EMT, self-renewal

A novel calcium-dependent mechanism of acquired resistance to IGF-1 receptor inhibition in prostate cancer cells Research Paper

Cale D. Fahrenholtz, Ann M. Greene, Pedro J. Beltran, Kerry L. Burnstein

Published Aug 19, 2014 · Vol. 5, No. 19 · pp. 9007-9021

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma Research Paper

Nathan F. Moore, Anna M. Azarova, Namrata Bhatnagar, Kenneth N. Ross, Lauren E. Drake, Stacey Frumm, Qinsong S. Liu, Amanda L. Christie, Takaomi Sanda, Louis Chesler, Andrew L. Kung, Nathanael S. Gray, Kimberly Stegmaier, Rani E. George

Published Aug 19, 2014 · Vol. 5, No. 18 · pp. 8737-8749

Selective JAK2/ABL dual inhibition therapy effectively eliminates TKI-insensitive CML stem/progenitor cells Research Paper

Hanyang Lin, Min Chen, Katharina Rothe, Matthew V. Lorenzi, Adrian Woolfson, Xiaoyan Jiang

Published Aug 16, 2014 · Vol. 5, No. 18 · pp. 8637-8650

Diacylglycerol kinase Î± promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src Research Paper

Pedro Torres-Ayuso, Manuel Daza-MartÃn, Jorge MartÃn-PÃ©rez, Antonia Ãvila-Flores, Isabel MÃ©rida

Published Aug 12, 2014 · Vol. 5, No. 20 · pp. 9710-9726

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors Research Paper

Burhan Hassan, Argun Akcakanat, Takafumi Sangai, Kurt W. Evans, Farrell Adkins, Agda Karina Eterovic, Hao Zhao, Ken Chen, Huiqin Chen, Kim-Anh Do, Shelly M. Xie, Ashley M. Holder, Aung Naing, Gordon B. Mills, Funda Meric-Bernstam

Published Aug 10, 2014 · Vol. 5, No. 18 · pp. 8544-8557

Spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance in colorectal cancer Research Paper

Anna Lena Ress, Verena Stiegelbauer, Daniela Schwarzenbacher, Alexander Deutsch, Samantha Perakis, Hui Ling, Cristina Ivan, George Adrian Calin, Beate Rinner, Armin Gerger, Martin Pichler

Published Aug 8, 2014 · Vol. 5, No. 18 · pp. 8492-8502

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells Research Paper

Frank Eckerdt, Elspeth Beauchamp, Jonathan Bell, Asneha Iqbal, Bing Su, Rikiro Fukunaga, Rishi R. Lulla, Stewart Goldman, Leonidas C. Platanias

Published Aug 6, 2014 · Vol. 5, No. 18 · pp. 8442-8451

Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner Research Paper

Akiko Morimoto, Satoshi Serada, Takayuki Enomoto, Ayako Kim, Shinya Matsuzaki, Tsuyoshi Takahashi, Yutaka Ueda, Kiyoshi Yoshino, Masami Fujita, Minoru Fujimoto, Tadashi Kimura, Tetsuji Naka

Published Aug 4, 2014 · Vol. 5, No. 17 · pp. 7776-7787

Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma Research Paper

Francois Lamoureux, Marc Baudâ€™huin, Benjamin Ory, Romain Guiho, Amina Zoubeidi, Martin Gleave, Dominique Heymann, FranÃ§oise RÃ©dini

Published Aug 4, 2014 · Vol. 5, No. 17 · pp. 7805-7819

Co-ordination of cell cycle, migration and stem cell-like activity in breast cancer Research Paper

Rebecca Lamb, Michael P. Lisanti, Robert B. Clarke, GÃ¶ran Landberg

Published Aug 4, 2014 · Vol. 5, No. 17 · pp. 7833-7842

Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells Research Paper

Masashi Idogawa, Tomoko Ohashi, Jun Sugisaka, Yasushi Sasaki, Hiromu Suzuki, Takashi Tokino

Published Jul 27, 2014 · Vol. 5, No. 17 · pp. 7540-7548

Epidermal growth factor receptor (EGFR) is an independent adverse prognostic factor in esophageal adenocarcinoma patients treated with cisplatin-based neoadjuvant chemotherapy Clinical Research Papers

Michaela Aichler, Martin Motschmann, Uta JÃ¼tting, Birgit Luber, Karen Becker, Katja Ott, Florian Lordick, Rupert Langer, Marcus Feith, JÃ¶rg RÃ¼diger Siewert, Axel Walch

Published Jul 26, 2014 · Vol. 5, No. 16 · pp. 6620-6632

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer Research Paper

Jorge Franco, Agnieszka . K. Witkiewicz, Erik S. Knudsen

Published Jul 26, 2014 · Vol. 5, No. 15 · pp. 6512-6525

Critical role of STAT3 in melanoma metastasis through anoikis resistance Research Paper

Neel M. Fofaria, Sanjay K. Srivastava

Published Jul 25, 2014 · Vol. 5, No. 16 · pp. 7051-7064

Dual PI3K/mTOR inhibition is required to effectively impair microenvironment survival signals in mantle cell lymphoma Research Paper

Laia Rosich, Arnau Montraveta, SÃlvia Xargay-Torrent, MÃ³nica LÃ³pez-Guerra, Jocabed RoldÃ¡n, Marta Aymerich, Itziar Salaverria, SÃlvia BeÃ, ElÃas Campo, Patricia PÃ©rez-GalÃ¡n, GaÃ«l RouÃ©, Dolors Colomer

Published Jul 25, 2014 · Vol. 5, No. 16 · pp. 6788-6800

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Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition Priority Research Paper

Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia Research Paper

p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-ÎºB pathway Research Paper

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms Research Paper

MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells Priority Research Paper

A novel calcium-dependent mechanism of acquired resistance to IGF-1 receptor inhibition in prostate cancer cells Research Paper

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma Research Paper

Selective JAK2/ABL dual inhibition therapy effectively eliminates TKI-insensitive CML stem/progenitor cells Research Paper

Diacylglycerol kinase Î± promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src Research Paper

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors Research Paper

Spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance in colorectal cancer Research Paper

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells Research Paper

Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner Research Paper

Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma Research Paper

Co-ordination of cell cycle, migration and stem cell-like activity in breast cancer Research Paper

Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells Research Paper

Epidermal growth factor receptor (EGFR) is an independent adverse prognostic factor in esophageal adenocarcinoma patients treated with cisplatin-based neoadjuvant chemotherapy Clinical Research Papers

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer Research Paper

Critical role of STAT3 in melanoma metastasis through anoikis resistance Research Paper

Dual PI3K/mTOR inhibition is required to effectively impair microenvironment survival signals in mantle cell lymphoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition Priority Research Paper

Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia Research Paper

p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-ÎºB pathway Research Paper

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms Research Paper

MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells Priority Research Paper

A novel calcium-dependent mechanism of acquired resistance to IGF-1 receptor inhibition in prostate cancer cells Research Paper

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma Research Paper

Selective JAK2/ABL dual inhibition therapy effectively eliminates TKI-insensitive CML stem/progenitor cells Research Paper

Diacylglycerol kinase Î± promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src Research Paper

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors Research Paper

Spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance in colorectal cancer Research Paper

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells Research Paper

Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner Research Paper

Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma Research Paper

Co-ordination of cell cycle, migration and stem cell-like activity in breast cancer Research Paper

Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells Research Paper

Epidermal growth factor receptor (EGFR) is an independent adverse prognostic factor in esophageal adenocarcinoma patients treated with cisplatin-based neoadjuvant chemotherapy Clinical Research Papers

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer Research Paper

Critical role of STAT3 in melanoma metastasis through anoikis resistance Research Paper

Dual PI3K/mTOR inhibition is required to effectively impair microenvironment survival signals in mantle cell lymphoma Research Paper