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A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

Molecular profiling of radical prostatectomy tissue from patients with no sign of progression identifies ERG as the strongest independent predictor of recurrence Research Paper

Wusheng Yan, Muhammad Jamal, Shyh-Han Tan, Yingjie Song, Denise Young, Yongmei Chen, Shilpa Katta, Kai Ying, Lakshmi Ravindranath, Tarah Woodle, Indu Kohaar, Jennifer Cullen, Jacob Kagan, Sudhir Srivastava, Albert Dobi, David G. McLeod, Inger L. Rosner, Isabell A. Sesterhenn, Alagarsamy Srinivasan, Shiv Srivastava, Gyorgy Petrovics

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6466-6483

Keywords: prostate cancer, NanoString, prognostic biomarker, biochemical recurrence, ERG

The predictive capability of immunohistochemistry and DNA sequencing for determining TP53 functional mutation status: a comparative study of 41 glioblastoma patients Research Paper

Aarash K. Roshandel, Christopher M. Busch, Jennifer Van Mullekom, Joshua A. Cuoco, Cara M. Rogers, Lisa S. Apfel, Eric A. Marvin, Harald W. Sontheimer, Robyn A. Umans

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6204-6218

Keywords: p53, TP53, immunohistochemistry, gene sequencing, glioblastoma multiforme

Predictive value of interim FDG-PET/CT findings in patients with diffuse large B-cell lymphoma treated with R-CHOP Research Paper

Kazuhiro Kitajima, Masaya Okada, Kyoko Yoshihara, Tazuko Tokugawa, Akihiro Sawada, Satoshi Yoshihara, Hiroya Tamaki, Yoshihiro Fujimori, Syuji Ueda, Hiroyuki Kawamoto, Junichi Taniguchi, Koichiro Yamakado

Published Sep 10, 2019 · Vol. 10, No. 52 · pp. 5403-5411

Keywords: non-Hodgkin lymphoma, PET-CT, progression-free survival

Preliminary observations on soluble programmed cell death protein-1 as a prognostic and predictive biomarker in patients with metastatic melanoma treated with patient-specific autologous vaccines Research Paper

Robert O. Dillman, Gabriel I. Nistor, Bryce T. McLelland, Candace Hsieh, Aleksandra J. Poole, Andrew N. Cornforth, Hans S. Keirstead

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5359-5371

Keywords: programmed cell death protein -1 (PD-1), dendritic cell vaccines, metastatic melanoma

Prognostic value of tumor growth kinetic parameters in prostate cancer patients Research Paper

Gennady M. Zharinov, Oleg A. Bogomolov, Natalia Yu. Neklasova, Grigory A. Raskin, Irina V. Chepurnaya, Sergey N. Bugrov, Vladimir N. Anisimov

Published Aug 20, 2019 · Vol. 10, No. 49 · pp. 5020-5027

Keywords: prostate cancer, cellular lost factor, Ki-67, prostate specific antigen doubling time, prognostic factors

Methylation alteration of SHANK1 as a predictive, diagnostic and prognostic biomarker for chronic lymphocytic leukemia Research Paper

Eleonora Loi, Loredana Moi, Antonio Fadda, Giannina Satta, Mariagrazia Zucca, Sonia Sanna, Shadi Amini Nia, Giuseppina Cabras, Marina Padoan, Corrado Magnani, Lucia Miligi, Sara Piro, Davide Gentilini, Maria Grazia Ennas, Melissa C. Southey, Graham G. Giles, Nicole Wong Doo, Pierluigi Cocco, Patrizia Zavattari

Published Aug 13, 2019 · Vol. 10, No. 48 · pp. 4987-5002

Keywords: cancer methylation alteration, predictive biomarkers, diagnostic biomarkers, prognostic biomarkers, SHANK1

Prognostic immune markers for recurrence and survival in locally advanced esophageal adenocarcinoma Research Paper

Laila Babar, Juliann E. Kosovec, Vida Jahangiri, Nobel Chowdhury, Ping Zheng, Ashten N. Omstead, Madison S. Salvitti, Matthew A. Smith, Ajay Goel, Ronan J. Kelly, Blair A. Jobe, Ali H. Zaidi

Published Jul 16, 2019 · Vol. 10, No. 44 · pp. 4546-4555

Keywords: esophageal adenocarcinoma, LAG3, IDO1, CXCL9, TIM3

Detecting predictive androgen receptor modifications in circulating prostate cancer cells Clinical Research Papers

Julie Steinestel, Manuel Luedeke, Annette Arndt, Thomas J. Schnoeller, Jochen K. Lennerz, Carina Wurm, Christiane Maier, Marcus V. Cronauer, Konrad Steinestel, Andres J. Schrader

Published Jun 25, 2019 · Vol. 10, No. 41 · pp. 4213-4223

Comparative genomic analysis of driver mutations in matched primary and recurrent meningiomas Research Paper

Joshua Loewenstern, John Rutland, Corey Gill, Hanane Arib, Margaret Pain, Melissa Umphlett, Yayoi Kinoshita, Russell McBride, Michael Donovan, Robert Sebra, Joshua Bederson, Mary Fowkes, Raj Shrivastava

Published May 28, 2019 · Vol. 10, No. 37 · pp. 3506-3517

Keywords: meningioma, tumor recurrence, genomics, driver mutation, progression-free survival

Target HER four in breast cancer? Research Perspective

Gero Brockhoff

Published May 7, 2019 · Vol. 10, No. 34 · pp. 3147-3150

Phase I/Ib study of olaparib and carboplatin in heavily pretreated recurrent high-grade serous ovarian cancer at low genetic risk Research Paper

Erika J. Lampert, John L. Hays, Elise C. Kohn, Christina M. Annunziata, Lori Minasian, Minshu Yu, Nicolas Gordon, Tristan M. Sissung, Victoria L. Chiou, William D. Figg, Nicole Houston, Jung-Min Lee

Published Apr 23, 2019 · Vol. 10, No. 30 · pp. 2855-2868

Keywords: high-grade serous ovarian cancer, BRCA wild type, olaparib, carboplatin

MicroRNA profiling of pancreatic ductal adenocarcinoma (PDAC) reveals signature expression related to lymph node metastasis Research Paper

Moran Lemberger, Shelly Loewenstein, Nir Lubezky, Eran Nizri, Metsada Pasmanik-Chor, Eli Barazovsky, Joseph M. Klausner, Guy Lahat

Published Apr 5, 2019 · Vol. 10, No. 27 · pp. 2644-2656

Biomarker results from a phase II study of MEK1/2 inhibitor binimetinib (MEK162) in patients with advanced NRAS- or BRAF-mutated melanoma Research Paper

Carla M.L. van Herpen, Sanjiv S. Agarwala, Axel Hauschild, Carola Berking, J. Thaddeus Beck, Dirk Schadendorf, Rob Jansen, Paola Queirolo, Paolo A. Ascierto, Christian U. Blank, Michael C. Heinrich, Rupam R. Pal, Adnan Derti, Victor Antona, Heidi Nauwelaerts, Angela Zubel, Reinhard Dummer

Published Mar 5, 2019 · Vol. 10, No. 19 · pp. 1850-1859

Phospho-ERK levels as predictors for chemotherapy of rectal carcinoma Research Paper

Susanne Holck, Louise Laurberg Klarskov, Lars-Inge Larsson

Published Mar 1, 2019 · Vol. 10, No. 18 · pp. 1745-1755

A targeted genomic alteration analysis predicts survival of melanoma patients under BRAF inhibitors Research Paper

Baptiste Louveau, Julie Delyon, Coralie Reger De Moura, Maxime Battistella, Fanelie Jouenne, Lisa Golmard, Aurelie Sadoux, Marie-Pierre Podgorniak, Ichrak Chami, Oren Marco, Julie Caramel, Stephane Dalle, Jean-Paul Feugeas, Nicolas Dumaz, Celeste Lebbe, Samia Mourah

Published Mar 1, 2019 · Vol. 10, No. 18 · pp. 1669-1687

Correction: Predictive biomarkers for disease sensitivity in lymphoma â€“ the holy grail for HDAC inhibitors? Correction

Toby A. Eyre

Published Feb 26, 2019 · Vol. 10, No. 17 · pp. 1661-1661

Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes Research Paper

Bernat Navarro-Serer, Eva P. Childers, Nicole M. Hermance, Dayna Mercadante, Amity L. Manning

Published Feb 26, 2019 · Vol. 10, No. 17 · pp. 1649-1659

Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer Research Paper

Ramona Graves-Deal, Galina Bogatcheva, Saba Rehman, Yuanyuan Lu, James N. Higginbotham, Bhuminder Singh

Published Feb 12, 2019 · Vol. 10, No. 13 · pp. 1320-1333

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A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Molecular profiling of radical prostatectomy tissue from patients with no sign of progression identifies ERG as the strongest independent predictor of recurrence Research Paper

The predictive capability of immunohistochemistry and DNA sequencing for determining TP53 functional mutation status: a comparative study of 41 glioblastoma patients Research Paper

Predictive value of interim FDG-PET/CT findings in patients with diffuse large B-cell lymphoma treated with R-CHOP Research Paper

Preliminary observations on soluble programmed cell death protein-1 as a prognostic and predictive biomarker in patients with metastatic melanoma treated with patient-specific autologous vaccines Research Paper

Prognostic value of tumor growth kinetic parameters in prostate cancer patients Research Paper

Methylation alteration of SHANK1 as a predictive, diagnostic and prognostic biomarker for chronic lymphocytic leukemia Research Paper

Prognostic immune markers for recurrence and survival in locally advanced esophageal adenocarcinoma Research Paper

Detecting predictive androgen receptor modifications in circulating prostate cancer cells Clinical Research Papers

Comparative genomic analysis of driver mutations in matched primary and recurrent meningiomas Research Paper

Target HER four in breast cancer? Research Perspective

Phase I/Ib study of olaparib and carboplatin in heavily pretreated recurrent high-grade serous ovarian cancer at low genetic risk Research Paper

MicroRNA profiling of pancreatic ductal adenocarcinoma (PDAC) reveals signature expression related to lymph node metastasis Research Paper

Biomarker results from a phase II study of MEK1/2 inhibitor binimetinib (MEK162) in patients with advanced NRAS- or BRAF-mutated melanoma Research Paper

Phospho-ERK levels as predictors for chemotherapy of rectal carcinoma Research Paper

A targeted genomic alteration analysis predicts survival of melanoma patients under BRAF inhibitors Research Paper

Correction: Predictive biomarkers for disease sensitivity in lymphoma â€“ the holy grail for HDAC inhibitors? Correction

Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes Research Paper

Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Molecular profiling of radical prostatectomy tissue from patients with no sign of progression identifies ERG as the strongest independent predictor of recurrence Research Paper

The predictive capability of immunohistochemistry and DNA sequencing for determining TP53 functional mutation status: a comparative study of 41 glioblastoma patients Research Paper

Predictive value of interim FDG-PET/CT findings in patients with diffuse large B-cell lymphoma treated with R-CHOP Research Paper

Preliminary observations on soluble programmed cell death protein-1 as a prognostic and predictive biomarker in patients with metastatic melanoma treated with patient-specific autologous vaccines Research Paper

Prognostic value of tumor growth kinetic parameters in prostate cancer patients Research Paper

Methylation alteration of SHANK1 as a predictive, diagnostic and prognostic biomarker for chronic lymphocytic leukemia Research Paper

Prognostic immune markers for recurrence and survival in locally advanced esophageal adenocarcinoma Research Paper

Detecting predictive androgen receptor modifications in circulating prostate cancer cells Clinical Research Papers

Comparative genomic analysis of driver mutations in matched primary and recurrent meningiomas Research Paper

Target HER four in breast cancer? Research Perspective

Phase I/Ib study of olaparib and carboplatin in heavily pretreated recurrent high-grade serous ovarian cancer at low genetic risk Research Paper

MicroRNA profiling of pancreatic ductal adenocarcinoma (PDAC) reveals signature expression related to lymph node metastasis Research Paper

Biomarker results from a phase II study of MEK1/2 inhibitor binimetinib (MEK162) in patients with advanced NRAS- or BRAF-mutated melanoma Research Paper

Phospho-ERK levels as predictors for chemotherapy of rectal carcinoma Research Paper

A targeted genomic alteration analysis predicts survival of melanoma patients under BRAF inhibitors Research Paper

Correction: Predictive biomarkers for disease sensitivity in lymphoma â€“ the holy grail for HDAC inhibitors? Correction

Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes Research Paper

Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer Research Paper