The Oncosearch | Oncotarget

PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling Research Paper

Reem Ali, Mashael Algethami, Amera Sheha, Shatha Alqahtani, Ahmad Altayyar, Ayat Lashen, Emad Rakha, Abdallah Alhaj Sulaiman, Srinivasan Madhusudan, Dindial Ramotar

Published May 3, 2025 · Vol. 16, No. 1 · pp. 362-378

Keywords: redox signaling, homologous recombination, protein interaction, cell cycle, protein modification

Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma Research Paper

Alexandra Jackovich, Barbara J. Gitlitz, Justin Wayne Wong Tiu-lim, Vinay Duddalwar, Kevin George King, Anthony B. El-Khoueiry, Jacob Stephen Thomas, Denice Tsao-Wei, David I. Quinn, Parkash S. Gill, Jorge J. Nieva

Published Jun 29, 2024 · Vol. 15, No. 1 · pp. 444-458

Keywords: EphrinB2, EphB4, HNSCC, pembrolizumab, HPV-negative

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

Thomas M. Cardillo, Maria B. Zalath, Roberto Arrojo, Robert M. Sharkey, Serengulam V. Govindan, Chien-Hsing Chang, David M. Goldenberg

Published Jan 30, 2024 · Vol. 15, No. 1 · pp. 144-158

Keywords: sacituzumab govitecan, Trop-2, SN-38, carboplatin, cisplatin

Transcriptomics reveals in vivo efficacy of PARP inhibitor combinatorial synergy with platinum-based chemotherapy in human non-small cell lung carcinoma models Research Paper

Lindsay R. Stolzenburg, Barrett Ainsworth, Bridget Riley-Gillis, Tibor Pakozdi, Areej Ammar, Paul A. Ellis, Julie L. Wilsbacher, Cyril Y. Ramathal

Published Dec 17, 2021 · Vol. 13, No. 1 · pp. 1-12

Keywords: PARP inhibitor, veliparib, cisplatin, transcriptomics, NSCLC

Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells Research Paper

Lindsey Carlsen, Christoph Schorl, Kelsey Huntington, Liz Hernandez-Borrero, Aakash Jhaveri, Shengliang Zhang, Lanlan Zhou, Wafik S. El-Deiry

Published Sep 8, 2021 · Vol. 12, No. 20 · pp. 2006-2021

Keywords: chemotherapy mechanism, colon cancer, 5-fluorouracil, irinotecan, oxaliplatin

Polyclonal on- and off-target resistance mutations in an EML4-ALK positive non-small cell lung cancer patient under ALK inhibition Case Report

Marcel Kemper, Georg Evers, Arik Bernard Schulze, Jan Sperveslage, Christoph Schülke, Georg Lenz, Thomas Herold, Wolfgang Hartmann, Hans-Ulrich Schildhaus, Annalen Bleckmann

Published Aug 23, 2021 · Vol. 12, No. 19 · pp. 1946-1952

Keywords: NSCLC, resistance mutations, ALK, KRAS, ALK inhibitors

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Nikolai Petrov, Hee-Sheung Lee, Mikhail Liskovykh, Marie-Paule Teulade-Fichou, Hiroshi Masumoto, William C. Earnshaw, Yves Pommier, Vladimir Larionov, Natalay Kouprina

Published Jun 27, 2021 · Vol. 12, No. 15 · pp. 1444-1456

Keywords: chromosome instability, CIN, platinum-derived G4-quadruplexes, telomere dysfunction, human artificial chromosome

Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells Research Paper

Andrew E. Greenstein, Hazel J. Hunt

Published Jun 9, 2021 · Vol. 12, No. 13 · pp. 1243-1255

Keywords: glucocorticoid, tumors, apoptosis, chemotherapy, drug resistance

Chemotherapy sensitivity testing on ovarian cancer cells isolated from malignant ascites Research Paper

Judith E. den Ouden, Guido J.R. Zaman, Jelle Dylus, Antoon M. van Doornmalen, Winfried R. Mulder, Yvonne Grobben, Wilhelmina E. van Riel, Joanne A. de Hullu, Rogier C. Buijsman, Anne M. van Altena

Published Nov 20, 2020 · Vol. 11, No. 49 · pp. 4570-4581

Keywords: ovarian cancer, chemotherapy sensitivity, prediction, ascites, proliferation assays

Regulation of breast cancer oncogenesis by the cell of origin’s differentiation state Research Paper

Sarah C. Petrova, Ihsaan Ahmad, Christine Nguyen, Stuart D. Ferrell Jr, Sabrina R. Wilhelm, Yin Ye, Sanford H. Barsky

Published Oct 10, 2020 · Vol. 11, No. 43 · pp. 3832-3848

Keywords: transgenic mice, induced pluripotent stem cells (iPSCs), breast oncogenesis, differentiation

Diversifying the platinum-based chemotherapy toolkit for immunogenic cancer cell death Editorial

Abhishek D. Garg, Patrizia Agostinis

Published Aug 13, 2020 · Vol. 11, No. 36 · pp. 3352-3353

Keywords: PT-112, immunogenic cell death (ICD), immune-checkpoint blockers (ICBs), tumour microenvironment, apoptosis

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells Research Paper

Al Hassan Kyakulaga, Farrukh Aqil, Radha Munagala, Ramesh C. Gupta

Published Apr 21, 2020 · Vol. 11, No. 16 · pp. 1399-1416

Keywords: non-small cell lung cancer, withaferin A, synergistic, combination index, paclitaxel

The prognostic role of microRNA in epithelial ovarian cancer: a systematic review of literature with an overall survival meta-analysis Review

Patricia Ferreira, Rosimeire Aparecida Roela, Rossana Veronica Mendoza Lopez, Maria Del Pilar Estevez-Diz

Published Mar 24, 2020 · Vol. 11, No. 12 · pp. 1085-1095

Keywords: ovarian cancer, microRNA, miRNA, prognostic factors, overall survival

Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer Research Paper

Irem Durmaz Sahin, Jenny-Maria Jönsson, Ingrid Hedenfalk

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6981-6996

Keywords: HGSOC, c-Met, PARP inhibitor, apoptosis

Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models Research Paper

Tony Yeung, Oliver Fung, Mikhail Bashkurov, Arian Khandani, Omar Subedar, Alexandra Wudwud, Patricia Shaw, Blaise Clarke, John Bartlett, Robert Rottapel, Andras Kapus

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6691-6712

Keywords: hyperploid genome, apoptosis, platinum chemotherapy, cell cycle checkpoint, ovarian cancer

Randomized phase 3 open label study of quality of life of patients on Pemetrexed versus Erlotinib as maintenance therapy for advanced non squamous non EGFR mutated non small cell lung cancer Research Paper

Vijay Patil, Amit Joshi, Vanita Noronha, Vivek Agarwala, Anuradha Chougule, Sadhana Kanan, Atanu Bhattacharjee, Arun Chandrasekharan, Nikhil Pande, Vijai Simha, Supriya Goud, Sucheta More, Rajiv Kumar, Abhishek Mahajan, Amit Janu, Nilendu Purandare, Kumar Prabhash

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6297-6307

Keywords: maintenance, pemetrexed, erlotinib, NSCLC

Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin Research Paper

Devika Rao, Atrayee Basu Mallick, Titto Augustine, Cecilia Daroqui, Jeeshan Jiffry, Amartej Merla, Imran Chaudhary, Raviraja Seetharam, Arjun Sood, Srikanth Gajavelli, Santiago Aparo, Lakshmi Rajdev, Andreas Kaubisch, Jennifer Chuy, Abdissa Negassa, John M. Mariadason, Radhashree Maitra, Sanjay Goel

Published Sep 17, 2019 · Vol. 10, No. 53 · pp. 5510-5522

Keywords: oxaliplatin, colorectal cancer, ERCC1, FOLFOX, resistance

Phase I/Ib study of olaparib and carboplatin in heavily pretreated recurrent high-grade serous ovarian cancer at low genetic risk Research Paper

Erika J. Lampert, John L. Hays, Elise C. Kohn, Christina M. Annunziata, Lori Minasian, Minshu Yu, Nicolas Gordon, Tristan M. Sissung, Victoria L. Chiou, William D. Figg, Nicole Houston, Jung-Min Lee

Published Apr 23, 2019 · Vol. 10, No. 30 · pp. 2855-2868

Keywords: high-grade serous ovarian cancer, BRCA wild type, olaparib, carboplatin

Body surface area-based versus concentration-based intraperitoneal perioperative chemotherapy in a rat model of colorectal peritoneal surface malignancy: pharmacologic guidance towards standardization Research Paper

Lieselotte Lemoine, Elsy Thijssen, Robert Carleer, Jirka Cops, Veerle Lemmens, Peter Van Eyken, Paul Sugarbaker, Kurt Van der Speeten

Published Feb 15, 2019 · Vol. 10, No. 14 · pp. 1407-1424

Clinical characteristics, treatment outcomes and potential novel therapeutic options for patients with neuroendocrine carcinoma of the prostate Research Paper

Leonidas Apostolidis, Cathleen Nientiedt, Eva Caroline Winkler, Anne Katrin Berger, Clemens Kratochwil, Annette Kaiser, Anne-Sophie Becker, Dirk JÃ¤ger, Markus Hohenfellner, Clemens HÃ¼ttenbrink, Sascha Pahernik, Florian A. Distler, Carsten GrÃ¼llich

Published Jan 1, 2019 · Vol. 10, No. 1 · pp. 17-29

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PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling Research Paper

Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma Research Paper

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

Transcriptomics reveals in vivo efficacy of PARP inhibitor combinatorial synergy with platinum-based chemotherapy in human non-small cell lung carcinoma models Research Paper

Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells Research Paper

Polyclonal on- and off-target resistance mutations in an EML4-ALK positive non-small cell lung cancer patient under ALK inhibition Case Report

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells Research Paper

Chemotherapy sensitivity testing on ovarian cancer cells isolated from malignant ascites Research Paper

Regulation of breast cancer oncogenesis by the cell of origin’s differentiation state Research Paper

Diversifying the platinum-based chemotherapy toolkit for immunogenic cancer cell death Editorial

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells Research Paper

The prognostic role of microRNA in epithelial ovarian cancer: a systematic review of literature with an overall survival meta-analysis Review

Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer Research Paper

Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models Research Paper

Randomized phase 3 open label study of quality of life of patients on Pemetrexed versus Erlotinib as maintenance therapy for advanced non squamous non EGFR mutated non small cell lung cancer Research Paper

Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin Research Paper

Phase I/Ib study of olaparib and carboplatin in heavily pretreated recurrent high-grade serous ovarian cancer at low genetic risk Research Paper

Body surface area-based versus concentration-based intraperitoneal perioperative chemotherapy in a rat model of colorectal peritoneal surface malignancy: pharmacologic guidance towards standardization Research Paper

Clinical characteristics, treatment outcomes and potential novel therapeutic options for patients with neuroendocrine carcinoma of the prostate Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling Research Paper

Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma Research Paper

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

Transcriptomics reveals in vivo efficacy of PARP inhibitor combinatorial synergy with platinum-based chemotherapy in human non-small cell lung carcinoma models Research Paper

Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells Research Paper

Polyclonal on- and off-target resistance mutations in an EML4-ALK positive non-small cell lung cancer patient under ALK inhibition Case Report

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells Research Paper

Chemotherapy sensitivity testing on ovarian cancer cells isolated from malignant ascites Research Paper

Regulation of breast cancer oncogenesis by the cell of origin’s differentiation state Research Paper

Diversifying the platinum-based chemotherapy toolkit for immunogenic cancer cell death Editorial

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells Research Paper

The prognostic role of microRNA in epithelial ovarian cancer: a systematic review of literature with an overall survival meta-analysis Review

Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer Research Paper

Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models Research Paper

Randomized phase 3 open label study of quality of life of patients on Pemetrexed versus Erlotinib as maintenance therapy for advanced non squamous non EGFR mutated non small cell lung cancer Research Paper

Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin Research Paper

Phase I/Ib study of olaparib and carboplatin in heavily pretreated recurrent high-grade serous ovarian cancer at low genetic risk Research Paper

Body surface area-based versus concentration-based intraperitoneal perioperative chemotherapy in a rat model of colorectal peritoneal surface malignancy: pharmacologic guidance towards standardization Research Paper

Clinical characteristics, treatment outcomes and potential novel therapeutic options for patients with neuroendocrine carcinoma of the prostate Research Paper