The Oncosearch | Oncotarget

Clinical utility of gene-expression profiling for tumor-site origin in patients with metastatic or poorly differentiated cancer: impact on diagnosis, treatment, and survival Research Paper

J Scott Nystrom, John C. Hornberger, Gauri R. Varadhachary, Richard J. Hornberger, Hialy R. Gutierrez, W. David Henner, Shawn H. Becker, Mahul B. Amin, Michael G. Walker

Published Jun 9, 2012 · Vol. 3, No. 6 · pp. 620-628

Keywords: cancer of unknown primary, diagnosis, genomics, clinical utility, tissue of origin

Novel Therapeutic Targets in the Brain Tumor Microenvironment Research Perspective

Joanna J. Phillips

Published May 25, 2012 · Vol. 3, No. 5 · pp. 568-575

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase. Research Paper

Hongdo Do, Alexander Dobrovic

Published May 24, 2012 · Vol. 3, No. 5 · pp. 546-558

Keywords: FFPE, cancer biopsies, sequencing artefacts, EGFR mutation, BRAF mutation, closed-tube analysis

BCL2L10 is a predictive factor for resistance to Azacitidine in MDS and AML patients Research Paper

Thomas Cluzeau, Guillaume Robert, Nicolas Mounier, Jean Michel Karsenti, Maeva Dufies, Alexandre Puissant, Arnaud Jacquel, Aline Renneville, Claude Preudhomme, Jill Patrice Cassuto, Sophie Raynaud, Frederic Luciano, Patrick Auberger

Published May 9, 2012 · Vol. 3, No. 4 · pp. 490-501

Keywords: MDS, Azacitidine, resistance, BCL2L10, prognosis

On the presence and role of human gene-body DNA methylation Research Paper

Daudi Jjingo, Andrew B. Conley, Soojin V. Yi, Victoria V. Lunyak, I. King Jordan

Published May 9, 2012 · Vol. 3, No. 4 · pp. 462-474

Keywords: genome-wide methylation, epigenetic mark, intragenic transcription, methylating enzyme complexes

Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts Brief Reports

SÃlvia CufÃ, Bruna Corominas-Faja, Alejandro Vazquez-Martin, Cristina Oliveras-Ferraros, Joan Dorca, Joaquim Bosch-Barrera, BegoÃ±a Martin-Castillo, Javier A Menendez

Published May 4, 2012 · Vol. 3, No. 4 · pp. 395-398

Keywords: metformin, trastuzumab, HER2, cancer stem cells, breast cancer

Folate Receptor Alpha Expression in Lung Cancer: Diagnostic and Prognostic Significance Research Paper

Daniel J. O'Shannessy, Gordon Yu, Robert Smale, Yao-Shi Fu, Sunil Singhal, Robert P. Thiel, Elizabeth B. Somers, Anil Vachani

Published Apr 29, 2012 · Vol. 3, No. 4 · pp. 414-425

Keywords: folate receptor alpha, FRA, non-small cell lung cancer, adenocarcinoma, prognosis, immunohistochemistry

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Veronique Mathieu, Christine Pirker, Wolfgang M Schmidt, Sabine Spiegl-Kreinecker, Daniela LÃ¶tsch, Petra Heffeter, Balazs Hegedus, Michael Grusch, Robert Kiss, Walter Berger

Published Apr 24, 2012 · Vol. 3, No. 4 · pp. 399-413

Keywords: malignant melanoma, aneuploidy, xenograft, aggressiveness, integrative genomics

Comprehensive Assessment of Potential Multiple Myeloma Immunoglobulin Heavy Chain V-D-J Intraclonal Variation Using Massively Parallel Pyrosequencing Methodological Reports

Renee C. Tschumper, Yan W. Asmann, Asif Hossain, Paul M. Huddleston, Xiaosheng Wu, Angela Dispenzieri, Bruce W. Eckloff, Diane F. Jelinek

Published Apr 20, 2012 · Vol. 3, No. 4 · pp. 502-513

Keywords: IGHV, multiple myeloma, massively parallel sequencing

The Expression of p-STAT3 in Stage IV Melanoma: Risk of CNS Metastasis and Survival Research Paper

Ian Lee, Patricia S. Fox, Sherise D. Ferguson, Roland L. Bassett, Jr., Ling-Yuan Kong, Christopher W. Schacherer, Jeffrey E. Gershenwald, Elizabeth A. Grimm, Gregory N. Fuller, Amy B. Heimberger

Published Apr 6, 2012 · Vol. 3, No. 3 · pp. 336-344

Keywords: melanoma, p-STAT3, CNS metastasis, prognosis

Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma Research Paper

Changping Li, Michael A. Thompson, Archito T. Tamayo, Zhuang Zuo, John Lee, Francisco Vega, Richard J. Ford, Lan V. Pham

Published Mar 23, 2012 · Vol. 3, No. 3 · pp. 314-326

Keywords: Trx-1, chemoresistance, DLBCL, cellular redox

Targeting Mnks for Cancer Therapy Review

Jinqiang Hou, Frankie Kam, Christopher G Proud, Shudong Wang

Published Mar 3, 2012 · Vol. 3, No. 2 · pp. 118-131

Keywords: eIF4E, Mnk, Ras, Raf, MAPK, Akt, PI3K, mTOR, Targeted Cancer Therapy, Structure based drug design, Mnk Inhibitors

microRNA-1/133a and microRNA-206/133b clusters: Dysregulation and functional roles in human cancers Review

Nijiro Nohata, Toyoyuki Hanazawa, Hideki Enokida, Naohiko Seki

Published Feb 4, 2012 · Vol. 3, No. 1 · pp. 9-21

Keywords: cancer, miRNA, miR-1, miR-133a, miR-133b, miR-206

Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma Research Paper

Hideo Hidaka, Naohiko Seki, Hirofumi Yoshino, Takeshi Yamasaki, Yasutoshi Yamada, Nijiro Nohata, Miki Fuse, Masayuki Nakagawa, Hideki Enokida

Published Jan 30, 2012 · Vol. 3, No. 1 · pp. 44-57

Keywords: microRNA, expression signature, miR-1285, tumor suppressor, renal cell carcinoma, transglutaminase 2

Regression of metastatic melanoma by targeting cancer stem cells Brief Reports

Max Schlaak, Patrick Schmidt, Christopher Bangard, Peter Kurschat, Cornelia Mauch, Hinrich Abken

Published Jan 28, 2012 · Vol. 3, No. 1 · pp. 22-30

Keywords: cancer stem cell, melanoma, CD20, rituximab

Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas. Brief Reports

Sandra Cantilena, Fabio Pastorino, Olesya Chayka, Annalisa Pezzolo, Vito Pistoia, Mirco Ponzoni, Arturo Sala

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 976-983

Keywords: HIF, hypoxia, metastasis, neuroblastoma, stem cell

A Modular Strategy to Prepare Multivalent Inhibitors of Prostate-Specific Membrane Antigen (PSMA) Research Paper

Sangeeta Ray Banerjee, Mrudula Pullambhatla, Hassan Shallal, Ala Lisok, Ronnie C. Mease, Martin G. Pomper

Published Dec 29, 2011 · Vol. 2, No. 12 · pp. 1244-1253

Keywords: Prostate-specific membrane antigen (PSMA), NAALADase, bivalent urea inhibitor, molecular imaging, multivalency, SPECT imaging

Characterization of the Human Folate Receptor Alpha Via Novel Antibody-Based Probes Research Paper

Daniel J. Oâ€™Shannessy, Elizabeth B. Somers, Earl Albone, Xin Cheng, Young Chul Park, Brian E. Tomkowicz, Yoshitomo Hamuro, Thomas O. Kohl, Tracy M. Forsyth, Robert Smale, Yao-Shi Fu, Nicholas C. Nicolaides

Published Dec 27, 2011 · Vol. 2, No. 12 · pp. 1227-1243

Finding cancerâ€™s weakest link Research Perspective

Nicole Michel Sodir, Gerard I. Evan

Published Dec 22, 2011 · Vol. 2, No. 12 · pp. 1307-1313

Keywords: Myc inhibition, tumor, microenvironment, cancer therapeutics

Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins Research Paper

Paula Vainio, Laura Lehtinen, Tuomas Mirtti, Mika Hilvo, Tuulikki SeppÃ¤nen-Laakso, Johannes Virtanen, Anna Sankila, Stig Nordling, Johan Lundin, Antti Rannikko, Matej OreÅ¡iÄ, Olli Kallioniemi, Kristiina Iljin

Published Dec 22, 2011 · Vol. 2, No. 12 · pp. 1176-1190

Keywords: Prostate cancer, PLA2G7, drug target, biomarker, statins

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Clinical utility of gene-expression profiling for tumor-site origin in patients with metastatic or poorly differentiated cancer: impact on diagnosis, treatment, and survival Research Paper

Novel Therapeutic Targets in the Brain Tumor Microenvironment Research Perspective

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase. Research Paper

BCL2L10 is a predictive factor for resistance to Azacitidine in MDS and AML patients Research Paper

On the presence and role of human gene-body DNA methylation Research Paper

Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts Brief Reports

Folate Receptor Alpha Expression in Lung Cancer: Diagnostic and Prognostic Significance Research Paper

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Comprehensive Assessment of Potential Multiple Myeloma Immunoglobulin Heavy Chain V-D-J Intraclonal Variation Using Massively Parallel Pyrosequencing Methodological Reports

The Expression of p-STAT3 in Stage IV Melanoma: Risk of CNS Metastasis and Survival Research Paper

Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma Research Paper

Targeting Mnks for Cancer Therapy Review

microRNA-1/133a and microRNA-206/133b clusters: Dysregulation and functional roles in human cancers Review

Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma Research Paper

Regression of metastatic melanoma by targeting cancer stem cells Brief Reports

Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas. Brief Reports

A Modular Strategy to Prepare Multivalent Inhibitors of Prostate-Specific Membrane Antigen (PSMA) Research Paper

Characterization of the Human Folate Receptor Alpha Via Novel Antibody-Based Probes Research Paper

Finding cancerâ€™s weakest link Research Perspective

Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Clinical utility of gene-expression profiling for tumor-site origin in patients with metastatic or poorly differentiated cancer: impact on diagnosis, treatment, and survival Research Paper

Novel Therapeutic Targets in the Brain Tumor Microenvironment Research Perspective

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase. Research Paper

BCL2L10 is a predictive factor for resistance to Azacitidine in MDS and AML patients Research Paper

On the presence and role of human gene-body DNA methylation Research Paper

Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts Brief Reports

Folate Receptor Alpha Expression in Lung Cancer: Diagnostic and Prognostic Significance Research Paper

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Comprehensive Assessment of Potential Multiple Myeloma Immunoglobulin Heavy Chain V-D-J Intraclonal Variation Using Massively Parallel Pyrosequencing Methodological Reports

The Expression of p-STAT3 in Stage IV Melanoma: Risk of CNS Metastasis and Survival Research Paper

Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma Research Paper

Targeting Mnks for Cancer Therapy Review

microRNA-1/133a and microRNA-206/133b clusters: Dysregulation and functional roles in human cancers Review

Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma Research Paper

Regression of metastatic melanoma by targeting cancer stem cells Brief Reports

Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas. Brief Reports

A Modular Strategy to Prepare Multivalent Inhibitors of Prostate-Specific Membrane Antigen (PSMA) Research Paper

Characterization of the Human Folate Receptor Alpha Via Novel Antibody-Based Probes Research Paper

Finding cancerâ€™s weakest link Research Perspective

Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins Research Paper