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The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma Research Paper

Cinzia Fionda, Maria Pia Abruzzese, Alessandra Zingoni, Francesca Cecere, Elisabetta Vulpis, Giovanna Peruzzi, Alessandra Soriani, Rosa Molfetta, Rossella Paolini, Maria Rosaria Ricciardi, Maria Teresa Petrucci, Angela Santoni, Marco Cippitelli

Published Jun 23, 2015 · Vol. 6, No. 27 · pp. 23609-23630

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis Research Paper

Carrie A Duckworth, Scott E Guimond, Paulina Sindrewicz, Ashley J Hughes, Neil S French, Lu-Yun Lian, Edwin A Yates, D Mark Pritchard, Jonathan M Rhodes, Jeremy E Turnbull, Lu-Gang Yu

Published Jun 23, 2015 · Vol. 6, No. 27 · pp. 23671-23687

Keywords: Galectin-3, metastasis, heparin

Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression Priority Research Paper

Liu Yang, Dongdong Fang, Huijun Chen, Yiyu Lu, Zheng Dong, Han-Fei Ding, Qing Jing, Shi-Bing Su, Shuang Huang

Published Jun 23, 2015 · Vol. 6, No. 25 · pp. 20801-20812

Exploring response signals and targets in aggressive unresectable hepatocellular carcinoma: an analysis of targeted therapy phase 1 trials Clinical Research Papers

Ishwaria M. Subbiah, Gerald S. Falchook, Ahmed O. Kaseb, Kenneth R. Hess, Apostolia M. Tsimberidou, Siqing Fu, Vivek Subbiah, David S. Hong, Aung Naing, Sarina A. Piha-Paul, Owais Akmal, Filip Janku, Razelle Kurzrock

Published Jun 23, 2015 · Vol. 6, No. 29 · pp. 28453-28462

Targeting cancer by binding iron: Dissecting cellular signaling pathways Review

Goldie Y.L. Lui, Zaklina Kovacevic, Vera Richardson, Angelica M. Merlot, Danuta S. Kalinowski, Des R. Richardson

Published Jun 23, 2015 · Vol. 6, No. 22 · pp. 18748-18779

Keywords: cancer, iron, chelators, thiosemicarbazones, signaling, AKT, MAPK, STAT, EMT, autophagy

Lovastatin overcomes gefitinib resistance through TNF-α signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo Research Paper

Sheng-Huei Yang, Hung-Yun Lin, Vincent H.S. Chang, Chien-Chung Chen, Yun-Ru Liu, Jinghan Wang, Keqiang Zhang, Xiaoqing Jiang, Yun Yen

Published Jun 23, 2015 · Vol. 6, No. 27 · pp. 23857-23873

Keywords: Cholangiocarcinomas, Combination therapy, Lovastatin, Gefitinib

Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion Research Paper

Claudio Pulito, Federica Mori, Andrea Sacconi, Luca Casadei, Maria Ferraiuolo, Maria Cristina Valerio, Raffaela Santoro, Frauke Goeman, Anna Maidecchi, Luisa Mattoli, Cesare Manetti, Silvia Di Agostino, Paola Muti, Giovanni Blandino, Sabrina Strano

Published Jun 22, 2015 · Vol. 6, No. 20 · pp. 18134-18150

Putative effectors for prognosis in lung adenocarcinoma are ethnic and gender specific Research Paper

Andrew Woolston, Nardnisa Sintupisut, Tzu-Pin Lu, Liang-Chuan Lai, Mong-Hsun Tsai, Eric Y. Chuang, Chen-Hsiang Yeang

Published Jun 22, 2015 · Vol. 6, No. 23 · pp. 19483-19499

NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1α- and AP-1-mediated VEGFa transcription Research Paper

Li Qin, Yan Xu, Yixiang Xu, Gang Ma, Lan Liao, Yelin Wu, Yi Li, Xian Wang, Xiaosong Wang, Jun Jiang, Jin Wang, Jianming Xu

Published Jun 20, 2015 · Vol. 6, No. 27 · pp. 23890-23904

New therapeutic strategies in neuroblastoma: combined targeting of a novel tyrosine kinase inhibitor and liposomal siRNAs against ALK Research Paper

Daniela Di Paolo, D. Yang, Fabio Pastorino, Laura Emionite, Michele Cilli, Antonio Daga, Elisa Destefanis, Annarita Di Fiore, Francesca Piaggio, Chiara Brignole, Xiaobao Xu, Chris Liang, James Gibbons, Mirco Ponzoni, Patrizia Perri

Published Jun 20, 2015 · Vol. 6, No. 30 · pp. 28774-28789

Cisplatin inhibits MEK1/2 Research Paper

Tetsu Yamamoto, Igor F. Tsigelny, Andreas W. GÃ¶tz, Stephen B. Howell

Published Jun 20, 2015 · Vol. 6, No. 27 · pp. 23510-23522

Keywords: MEK1, RAS, ERK, copper, cisplatin

E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines Research Paper

Liming Li, Cui Xu, Jia Long, Danbei Shen, Wuqing Zhou, Qiyan Zhou, Jia Yang, Mingjun Jiang

Published Jun 19, 2015 · Vol. 6, No. 27 · pp. 23930-23943

A MEK/PI3K/HDAC inhibitor combination therapy for KRAS mutant pancreatic cancer cells Priority Research Paper

Irene Ischenko, Oleksi Petrenko, Michael J. Hayman

Published Jun 19, 2015 · Vol. 6, No. 18 · pp. 15814-15827

A fully human chimeric antigen receptor with potent activity against cancer cells but reduced risk for off-tumor toxicity Research Paper

De-Gang Song, Qunrui Ye, Mathilde Poussin, Lin Liu, Mariangela Figini, Daniel J. Powell Jr.

Published Jun 19, 2015 · Vol. 6, No. 25 · pp. 21533-21546

Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth Research Paper

Yan Dong, Baoping Cao, Meiying Zhang, Weidong Han, James G. Herman, FranÃ§ois Fuks, Yali Zhao, Mingzhou Guo

Published Jun 19, 2015 · Vol. 6, No. 26 · pp. 22126-22138

Six stroma-based RNA markers diagnostic for prostate cancer in European-Americans validated at the RNA and protein levels in patients in China Clinical Research Papers

Jianguo Zhu, Cong Pan, Jun Jiang, Mingsen Deng, Hengjun Gao, Bozhao Men, Michael McClelland, Dan Mercola, Wei-De Zhong, Zhenyu Jia

Published Jun 19, 2015 · Vol. 6, No. 18 · pp. 16757-16765

Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor Research Paper

Jason Chesney, Jennifer Clark, Lilibeth Lanceta, John O. Trent, Sucheta Telang

Published Jun 19, 2015 · Vol. 6, No. 20 · pp. 18001-18011

Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies Review

Giovanni Brandi, Andrea Farioli, Annalisa Astolfi, Guido Biasco, Simona Tavolari

Published Jun 19, 2015 · Vol. 6, No. 17 · pp. 14744-14753

In1-ghrelin, a splice variant of ghrelin gene, is associated with the evolution and aggressiveness of human neuroendocrine tumors: Evidence from clinical, cellular and molecular parameters Research Paper

Raul M. Luque, Miguel Sampedro-NuÃ±ez, Manuel D. Gahete, Ana Ramos-Levi, Alejandro IbÃ¡Ã±ez-Costa, Esther Rivero-CortÃ©s, Ana Serrano-Somavilla, Magdalena Adrados, Michael Culler, Justo CastaÃ±o, MÃ³nica Marazuela

Published Jun 18, 2015 · Vol. 6, No. 23 · pp. 19619-19633

RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy Review

Paola Indovina, Francesca Pentimalli, Nadia Casini, Immacolata Vocca, Antonio Giordano

Published Jun 18, 2015 · Vol. 6, No. 20 · pp. 17873-17890

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The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma Research Paper

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis Research Paper

Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression Priority Research Paper

Exploring response signals and targets in aggressive unresectable hepatocellular carcinoma: an analysis of targeted therapy phase 1 trials Clinical Research Papers

Targeting cancer by binding iron: Dissecting cellular signaling pathways Review

Lovastatin overcomes gefitinib resistance through TNF-α signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo Research Paper

Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion Research Paper

Putative effectors for prognosis in lung adenocarcinoma are ethnic and gender specific Research Paper

NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1α- and AP-1-mediated VEGFa transcription Research Paper

New therapeutic strategies in neuroblastoma: combined targeting of a novel tyrosine kinase inhibitor and liposomal siRNAs against ALK Research Paper

Cisplatin inhibits MEK1/2 Research Paper

E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines Research Paper

A MEK/PI3K/HDAC inhibitor combination therapy for KRAS mutant pancreatic cancer cells Priority Research Paper

A fully human chimeric antigen receptor with potent activity against cancer cells but reduced risk for off-tumor toxicity Research Paper

Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth Research Paper

Six stroma-based RNA markers diagnostic for prostate cancer in European-Americans validated at the RNA and protein levels in patients in China Clinical Research Papers

Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor Research Paper

Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies Review

In1-ghrelin, a splice variant of ghrelin gene, is associated with the evolution and aggressiveness of human neuroendocrine tumors: Evidence from clinical, cellular and molecular parameters Research Paper

RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma Research Paper

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis Research Paper

Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression Priority Research Paper

Exploring response signals and targets in aggressive unresectable hepatocellular carcinoma: an analysis of targeted therapy phase 1 trials Clinical Research Papers

Targeting cancer by binding iron: Dissecting cellular signaling pathways Review

Lovastatin overcomes gefitinib resistance through TNF-α signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo Research Paper

Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion Research Paper

Putative effectors for prognosis in lung adenocarcinoma are ethnic and gender specific Research Paper

NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1α- and AP-1-mediated VEGFa transcription Research Paper

New therapeutic strategies in neuroblastoma: combined targeting of a novel tyrosine kinase inhibitor and liposomal siRNAs against ALK Research Paper

Cisplatin inhibits MEK1/2 Research Paper

E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines Research Paper

A MEK/PI3K/HDAC inhibitor combination therapy for KRAS mutant pancreatic cancer cells Priority Research Paper

A fully human chimeric antigen receptor with potent activity against cancer cells but reduced risk for off-tumor toxicity Research Paper

Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth Research Paper

Six stroma-based RNA markers diagnostic for prostate cancer in European-Americans validated at the RNA and protein levels in patients in China Clinical Research Papers

Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor Research Paper

Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies Review

In1-ghrelin, a splice variant of ghrelin gene, is associated with the evolution and aggressiveness of human neuroendocrine tumors: Evidence from clinical, cellular and molecular parameters Research Paper

RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy Review