The Oncosearch | Oncotarget

Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients Precision Oncology

Wafik S. El-Deiry, Catherine Bresson, Fanny Wunder, Benedito A. Carneiro, Don S. Dizon, Jeremy L. Warner, Stephanie L. Graff, Christopher G. Azzoli, Eric T. Wong, Liang Cheng, Sendurai A. Mani, Howard P. Safran, Casey Williams, Tobias Meissner, Benjamin Solomon, Eitan Rubin, Angel Porgador, Guy Berchem, Pierre Saintigny, Amir Onn, Jair Bar, Raanan Berger, Manon Gantenbein, Zhen Chen, Cristiano de Pádua Souza, Rui Manuel Vieira Reis, Marina Sekacheva, Andrés Cervantes, William L. Dahut, Christina M. Annunziata, Kerri Gober, Khaled M. Musallam, Humaid O. Al-Shamsi, Ibrahim Abu-Gheida, Ramon Salazar, Sewanti Limaye, Adel T. Aref, Roger R. Reddel, Mohammed Ussama Al Homsi, Abdul Rouf, Said Dermime, Jassim Al Suwaidi, Catalin Vlad, Rares Buiga, Amal Al Omari, Hikmat Abdel-Razeq, Luis F. Oñate-Ocaña, Finn Cilius Nielsen, Leah Graham, Jens Rueter, Anthony M. Joshua, Eugenia Girda, Steven Libutti, Gregory Riedlinger, Mohammed E. Salem, Carol J. Farhangfar, Ruben A. Mesa, Bishoy M. Faltas, Olivier Elemento, C.S. Pramesh, Manju Sengar, Satoru Aoyama, Sadakatsu Ikeda, Ioana Berindan-Neagoe, Himabindu Gaddipati, Mandar Kulkarni, Elisabeth Auzias, Maria Gerogianni, Nicolas Wolikow, Simon Istolainen, Pessie Schlafrig, Naftali Z. Frankel, Amanda R. Ferraro, Jim Palma, Alejandro Piris Gimenez, Alberto Hernando-Calvo, Enriqueta Felip, Apostolia M. Tsimberidou, Roy S. Herbst, Josep Tabernero, Richard L. Schilsky, Jia Liu, Yves Lussier, Jacques Raynaud, Gerald Batist, Shai Magidi, Razelle Kurzrock

Published Mar 12, 2025 · Vol. 16, No. 1 · pp. 140-162

Keywords: precision oncology, N-of-1 basket trials, AI algorithms, digital pathology, drug access

Effect of TIMPs and their minimally engineered variants in blocking invasion and migration of brain cancer cells Research Paper

Elham Taheri, Maryam Raeeszadeh-Sarmazdeh

Published Feb 6, 2025 · Vol. 16, No. 1 · pp. 118-130

Keywords: TIMP minimal variants, glioblastoma multiforme (GBM), brain cancer, MMP inhibitors

Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells Research Paper

Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, Fred Bunz

Published Feb 6, 2025 · Vol. 16, No. 1 · pp. 79-100

Keywords: p53, ionizing radiation, immortalized cells, ALDH3A1, NECTIN4

Leukopenia, weight loss and oral mucositis induced by 5-Fluorouracil in hamsters’ model: A regenerative approach using electrospun poly(Lactic-co-Glycolic Acid) membrane Research Paper

Ana Chor, Hélio dos Santos Dutra, Marcos Lopes Dias, Raquel Pires Gonçalves, Alexandre Malta Rossi, Christina Maeda Takiya, Marcos Farina

Published Jan 22, 2025 · Vol. 16, No. 1 · pp. 103-117

Keywords: leukopenia, weight loss, oral mucositis, PLGA dressing, regeneration

Assessment of cfDNA release dynamics during colorectal cancer surgery Research Paper

Mailson Alves Lopes, Maria Elvira Ribeiro Cordeiro, Flávio de Alencar Teles Barreto, Lara de Souza Moreno, André Araújo de Medeiros Silva, Mariana Braccialli de Loyola, Mayra Veloso Ayrimoraes Soares, Joao Batista de Sousa, Fabio Pittella-Silva

Published Jan 9, 2025 · Vol. 16, No. 1 · pp. 29-38

Keywords: colorectal cancer, cfDNA, surgery

Mesenchymal stem cells - the secret agents of cancer immunotherapy: Promises, challenges, and surprising twists Review

Theia Minev, Shani Balbuena, Jaya Mini Gill, Francesco M. Marincola, Santosh Kesari, Feng Lin

Published Nov 9, 2024 · Vol. 15, No. 1 · pp. 793-805

Keywords: mesenchymal stem cells, genetic engineering, cancer immunotherapy, mesenchymal stem cell homing, stem cell delivery

Relationship between the expressions of DLL3, ASC1, TTF-1 and Ki-67: First steps of precision medicine at SCLC Research Paper

Samuel Silva, Juliana C. Sousa, Cleto Nogueira, Raquel Feijo, Francisco Martins Neto, Laura Cardoso Marinho, Guilherme Sousa, Valeria Denninghoff, Fabio Tavora

Published Oct 4, 2024 · Vol. 15, No. 1 · pp. 750-763

Keywords: DLL3, pathology, biomarkers, qupath, small cell carcinoma

Molecular chaperones: Guardians of tumor suppressor stability and function Review

Jennifer A. Heritz, Sarah J. Backe,, Mehdi Mollapour

Published Sep 21, 2024 · Vol. 15, No. 1 · pp. 679-696

Keywords: molecular chaperone, tumor suppressor, renal cell carcinoma, Birt-Hogg-Dubé (BHD) syndrome, TSC syndrome

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

Madison Rackear, Elias Quijano, Zaira Ianniello, Daniel A. Colón-Ríos, Adam Krysztofiak, Rashed Abdullah, Yanfeng Liu, Faye A. Rogers, Dale L. Ludwig, Rohini Dwivedi, Franziska Bleichert, Peter M. Glazer

Published Sep 20, 2024 · Vol. 15, No. 1 · pp. 699-713

Keywords: 3E10, cell penetration, nucleic acid binding, nucleic acid delivery, RAD51

UBA1 dysfunction in VEXAS and cancer Research Perspective

Maki Sakuma, Torsten Haferlach, Wencke Walter

Published Aug 27, 2024 · Vol. 15, No. 1 · pp. 644-658

Keywords: VEXAS, MDS, clonal cytopenia, ubiquitin, inflammation

A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice Research Paper

Zhen Li, Mohammed A. Alshagawi, Rebecca A. Oot, Mariam K. Alamoudi, Kevin Su, Wenhui Li, Michael P. Collins, Stephan Wilkens, Michael Forgac

Published Aug 5, 2024 · Vol. 15, No. 1 · pp. 575-587

Keywords: vacuolar ATPase, breast cancer, invasion, tumor metastasis, tumor growth

Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival Research Paper

Saif Zaman, Fred S. Gorelick, Andrea Chrobrutskiy, Boris I. Chobrutskiy, Gary V. Desir, George Blanck

Published Jul 20, 2024 · Vol. 15, No. 1 · pp. 550-561

Keywords: RNLS, melanoma, T-cell receptor CDR3s, chemical complementarity

Regorafenib synergizes with TAS102 against multiple gastrointestinal cancers and overcomes cancer stemness, trifluridine-induced angiogenesis, ERK1/2 and STAT3 signaling regardless of KRAS or BRAF mutational status Research Paper

Jun Zhang, Lanlan Zhou, Shuai Zhao, Wafik S. El-Deiry

Published Jun 24, 2024 · Vol. 15, No. 1 · pp. 424-438

Keywords: TAS102, regorafenib, ERK1/2, angiogenesis, microvessel density

Retraction: Superior efficacy of the antifungal agent ciclopirox olamine over gemcitabine in pancreatic cancer models Retraction

Chrysovalantou Mihailidou, Pavlos Papakotoulas, Athanasios G. Papavassiliou, Michalis V. Karamouzis

Published Jun 21, 2024 · Vol. 15, No. 1 · pp. 461-461

The importance of integrated therapies on cancer: Silibinin, an old and new molecule Review

Elisa Roca, Giuseppe Colloca, Fiorella Lombardo, Andrea Bellieni, Alessandra Cucinella, Giorgio Madonia, Licia Martinelli, Maria Elisa Damiani, Ilaria Zampieri, Antonio Santo

Published May 14, 2024 · Vol. 15, No. 1 · pp. 345-353

Keywords: silibinin, anti-inflammatory, inflammation, toxicity, integrated therapy

GZ17-6.02 kills PDX isolates of uveal melanoma Research Paper

Laurence Booth, Jane L. Roberts, Ivan Spasojevic, Kaitlyn C. Baker, Andrew Poklepovic, Cameron West, John M. Kirkwood, Paul Dent

Published May 9, 2024 · Vol. 15, No. 1 · pp. 328-344

Keywords: autophagy, ER stress, GZ17-6.02, doxorubicin, afatinib, neratinib

The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response Research Paper

Lulzim Shkreta, Johanne Toutant, Aurélie Delannoy, David Durantel, Anna Salvetti, Sophie Ehresmann, Martin Sauvageau, Julien A. Delbrouck, Alice Gravel-Trudeau, Christian Comeau, Caroline Huard, Jasmin Coulombe-Huntington, Mike Tyers, David Grierson, Pierre-Luc Boudreault, Benoit Chabot

Published May 9, 2024 · Vol. 15, No. 1 · pp. 313-325

Keywords: CLK kinases inhibitors, EMT, antiviral immune response, microtubules, metastasis

Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN Research Paper

Kevin C. Ma, Esther Mena, Liza Lindenberg, Nathan S. Lay, Phillip Eclarinal, Deborah E. Citrin, Peter A. Pinto, Bradford J. Wood, William L. Dahut, James L. Gulley, Ravi A. Madan, Peter L. Choyke, Ismail Baris Turkbey, Stephanie A. Harmon

Published May 2, 2024 · Vol. 15, No. 1 · pp. 288-300

Keywords: deep learning, PSMA PET, attenuation correction

Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure Research Paper

Shengliang Zhang, Wafik S. El-Deiry

Published Apr 29, 2024 · Vol. 15, No. 1 · pp. 275-284

Keywords: SARS-COV2 spike, p53, MDM2, chemotherapy, cancer

Novel therapeutic bispecific antibodies for B-cell lymphoma targeting IgM and other antigens on the B-cell surface Research Paper

Takahiro Ohashi, Sayuri Terada, Shinsuke Hiramoto, Yuko Nagata, Hirokazu Suzuki, Hitoshi Miyashita, Tetsuo Sasaki, Yasukatsu Tsukada, Keiko Fukushima

Published Mar 29, 2024 · Vol. 15, No. 1 · pp. 256-274

Keywords: bispecific antibody, Cys1m, IgM, lymphoma, cynomolgus monkey

Publication Alerts

European Cancer and Oncology Congress

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Search Oncotarget

Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients Precision Oncology

Effect of TIMPs and their minimally engineered variants in blocking invasion and migration of brain cancer cells Research Paper

Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells Research Paper

Leukopenia, weight loss and oral mucositis induced by 5-Fluorouracil in hamsters’ model: A regenerative approach using electrospun poly(Lactic-co-Glycolic Acid) membrane Research Paper

Assessment of cfDNA release dynamics during colorectal cancer surgery Research Paper

Mesenchymal stem cells - the secret agents of cancer immunotherapy: Promises, challenges, and surprising twists Review

Relationship between the expressions of DLL3, ASC1, TTF-1 and Ki-67: First steps of precision medicine at SCLC Research Paper

Molecular chaperones: Guardians of tumor suppressor stability and function Review

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

UBA1 dysfunction in VEXAS and cancer Research Perspective

A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice Research Paper

Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival Research Paper

Regorafenib synergizes with TAS102 against multiple gastrointestinal cancers and overcomes cancer stemness, trifluridine-induced angiogenesis, ERK1/2 and STAT3 signaling regardless of KRAS or BRAF mutational status Research Paper

Retraction: Superior efficacy of the antifungal agent ciclopirox olamine over gemcitabine in pancreatic cancer models Retraction

The importance of integrated therapies on cancer: Silibinin, an old and new molecule Review

GZ17-6.02 kills PDX isolates of uveal melanoma Research Paper

The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response Research Paper

Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN Research Paper

Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure Research Paper

Novel therapeutic bispecific antibodies for B-cell lymphoma targeting IgM and other antigens on the B-cell surface Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients Precision Oncology

Effect of TIMPs and their minimally engineered variants in blocking invasion and migration of brain cancer cells Research Paper

Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells Research Paper

Leukopenia, weight loss and oral mucositis induced by 5-Fluorouracil in hamsters’ model: A regenerative approach using electrospun poly(Lactic-co-Glycolic Acid) membrane Research Paper

Assessment of cfDNA release dynamics during colorectal cancer surgery Research Paper

Mesenchymal stem cells - the secret agents of cancer immunotherapy: Promises, challenges, and surprising twists Review

Relationship between the expressions of DLL3, ASC1, TTF-1 and Ki-67: First steps of precision medicine at SCLC Research Paper

Molecular chaperones: Guardians of tumor suppressor stability and function Review

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

UBA1 dysfunction in VEXAS and cancer Research Perspective

A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice Research Paper

Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival Research Paper

Regorafenib synergizes with TAS102 against multiple gastrointestinal cancers and overcomes cancer stemness, trifluridine-induced angiogenesis, ERK1/2 and STAT3 signaling regardless of KRAS or BRAF mutational status Research Paper

Retraction: Superior efficacy of the antifungal agent ciclopirox olamine over gemcitabine in pancreatic cancer models Retraction

The importance of integrated therapies on cancer: Silibinin, an old and new molecule Review

GZ17-6.02 kills PDX isolates of uveal melanoma Research Paper

The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response Research Paper

Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN Research Paper

Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure Research Paper

Novel therapeutic bispecific antibodies for B-cell lymphoma targeting IgM and other antigens on the B-cell surface Research Paper