The Oncosearch | Oncotarget

Phase I dose escalation study of 12b80 (hydroxybisphosphonate linked doxorubicin) in naturally occurring osteosarcoma Research Paper

Pierre Boyé, Emmanuelle David, François Serres, Quentin Pascal, Franck Floch, Kévyn Geeraert, Virginie Coste, Laurent Marescaux, Sébastien Cagnol, Jean-Yves Goujon, Maxim Egorov, Ronan Le Bot, Dominique Tierny

Published Nov 3, 2020 · Vol. 11, No. 46 · pp. 4281-4292

Keywords: bisphosphonate, bone targeting, canine, doxorubicin, osteosarcoma

HER2 splice variants in breast cancer: investigating their impact on diagnosis and treatment outcomes Review

Vic Hart, Hannah Gautrey, John Kirby, Alison Tyson-Capper

Published Oct 22, 2020 · Vol. 11, No. 46 · pp. 4338-4357

Keywords: HER2, Δ16-HER2, splice variant, breast cancer, trastuzumab

Histo-molecular differentiation of renal cancer subtypes by mass spectrometry imaging and rapid proteome profiling of formalin-fixed paraffin-embedded tumor tissue sections Research Paper

Uwe Möginger, Niels Marcussen, Ole N. Jensen

Published Oct 21, 2020 · Vol. 11, No. 44 · pp. 3998-4015

Keywords: renal cell cancer, MALDI mass spectrometry imaging (MALDI MSI), microproteomics, statistical classification, liquid chromatography mass spectrometry (LC-MS)

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Marion Dubuissez, Sonia Paget, Souhila Abdelfettah, Nathalie Spruyt, Vanessa Dehennaut, Gaylor Boulay, Ingrid Loison, Clementine de Schutter, Brian R. Rood, Martine Duterque-Coquillaud, Xavier Leroy, Dominique Leprince

Published Oct 21, 2020 · Vol. 11, No. 45 · pp. 4138-4154

Keywords: HIC1, CXCL12, SDF1, α-SMA, Acta2

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Niraj Lodhi, Moe Tun, Poonam Nagpal, Arati A. Inamdar, Nehad M. Ayoub, Noor Siyam, Lucia Oton-Gonzalez, Angela Gerona, Dainelle Morris, Rana Sandhu, Kwangsun Stephen Suh

Published Oct 20, 2020 · Vol. 11, No. 44 · pp. 4045-4073

Keywords: DLBCL, diagnosis, R-CHOP, precision medicine, prognosis

PD-1/PD-L1 expression in anal squamous intraepithelial lesions Research Paper

Margot Bucau, Nathalie Gault, Nanthara Sritharan, Emy Valette, Charlotte Charpentier, Francine Walker, Anne Couvelard, Laurent Abramowitz

Published Sep 17, 2020 · Vol. 11, No. 39 · pp. 3582-3589

Keywords: anal dysplasia, PD-L1, HPV, anal cancer, immune microenvironment

A comprehensive analysis of clinical trials in pancreatic cancer: what is coming down the pike? Research Paper

Erryk S. Katayama, Jonathan J. Hue, David L. Bajor, Lee M. Ocuin, John B. Ammori, Jeffrey M. Hardacre, Jordan M. Winter

Published Aug 24, 2020 · Vol. 11, No. 38 · pp. 3489-3501

Keywords: pancreatic cancer, pancreatic ductal adenocarcinoma, clinical trial, novel treatment, drug development

Therapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin’s lymphoma to many other types of solid cancers Research Paper

Rod Balhorn, Monique Cosman Balhorn

Published Aug 5, 2020 · Vol. 11, No. 35 · pp. 3315-3349

Keywords: HLA-DR, selective high affinity ligand, SH7139, SH7129, solid cancers

Sequencing for an interdisciplinary molecular tumor board in patients with advanced breast cancer: experiences from a case series Research Paper

Christina Walter, Andreas Hartkopf, Andre Koch, Marion Klaumünzer, Martin Schulze, Eva-Maria Grischke, Florin-Andrei Taran, Sara Brucker, Florian Battke, Saskia Biskup

Published Aug 1, 2020 · Vol. 11, No. 35 · pp. 3279-3285

Keywords: breast cancer, genetics, next-generation sequencing, actionable mutations

Obinutuzumab (GA101) vs. rituximab significantly enhances cell death, antibody-dependent cytotoxicity and improves overall survival against CD20+ primary mediastinal B-cell lymphoma (PMBL) in a xenograft NOD-scid IL2Rgnull (NSG) mouse model: a potential targeted agent in the treatment of PMBL Research Paper

Yaya Chu, Aradhana Awasthi, Sanghoon Lee, Dina Edani, Changhong Yin, Jessica Hochberg, Tishi Shah, Tae-Hoon Chung, Janet Ayello, Carmella van de Ven, Christian Klein, Dean Lee, Mitchell S. Cairo

Published Jul 21, 2020 · Vol. 11, No. 32 · pp. 3035-3047

Keywords: Obinutuzumab, rituximab, survival, primary mediastinal large B-cell lymphoma, antibody-dependent cellular cytotoxicity

The NKL-code for innate lymphoid cells reveals deregulated expression of NKL homeobox genes HHEX and HLX in anaplastic large cell lymphoma (ALCL) Research Paper

Stefan Nagel, Claudia Pommerenke, Roderick A.F. MacLeod, Corinna Meyer, Maren Kaufmann, Hans G. Drexler

Published Jul 15, 2020 · Vol. 11, No. 34 · pp. 3208-3226

Keywords: homeobox, NKL-code, T-ALL, LL-100, Th17

Epigenetic feedback and stochastic partitioning during cell division can drive resistance to EMT Research Paper

Wen Jia, Shubham Tripathi, Priyanka Chakraborty, Adithya Chedere, Annapoorni Rangarajan, Herbert Levine, Mohit Kumar Jolly

Published Jun 11, 2020 · Vol. 11, No. 27 · pp. 2611-2624

Keywords: epithelial-mesenchymal transition, mesenchymal-epithelial transition, GRHL2, epigenetics, asymmetric cell division

Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation Research Paper

Ron C. Gaba, Lobna Elkhadragy, F. Edward Boas, Sulalita Chaki, Hanna H. Chen, Mohammed El-Kebir, Kelly D. Garcia, Eileena F. Giurini, Grace Guzman, Francesca V. LoBianco, Mario F. Neto, Jordan L. Newson, Aisha Qazi, Maureen Regan, Lauretta A. Rund, Regina M. Schwind, Matthew C. Stewart, Faith M. Thomas, Herbert E. Whiteley, Jiaqi Wu, Lawrence B. Schook, Kyle M. Schachtschneider

Published Jun 10, 2020 · Vol. 11, No. 28 · pp. 2686-2701

Keywords: liver cancer, transgenic pigs, large animal model, interventional radiology, personalized medicine

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

Rive Sarfstein, Haim Werner

Published Jun 9, 2020 · Vol. 11, No. 25 · pp. 2424-2437

Keywords: insulin, insulin-like growth factor-1 (IGF1), insulin receptor, IGF1 receptor, p53

Profiling the circulating mRNA transcriptome in human liver disease Research Paper

Aejaz Sayeed, Brielle E. Dalvano, David E. Kaplan, Usha Viswanathan, John Kulp, Alhaji H. Janneh, Lu-Yu Hwang, Adam Ertel, Cataldo Doria, Timothy Block

Published May 23, 2020 · Vol. 11, No. 23 · pp. 2216-2232

Keywords: hepatocellular carcinoma, circulating transcripts, biomarkers, liver cirrhosis, extracellular vesicles

Neuroendocrine carcinoma of uterine cervix findings shown by MRI for staging and survival analysis – Japan multicenter study Research Paper

Kazuhiro Kitajima, Takako Kihara, Yusuke Kawanaka, Aki Kido, Kotaro Yoshida, Yasunari Mizumoto, Akiko Tomiyama, Shigeo Okuda, Masahiro Jinzaki, Fumi Kato, Junko Takahama, Akiko Takahata, Yoshihiko Fukukura, Atsushi Nakamoto, Tetsuya Tsujikawa, Jiro Munechika, Yoshimitstu Ohgiya, Nobuyuki Kawai, Satoshi Goshima, Ayumi Ohya, Yasunari Fujinaga, Takeru Fukunaga, Shinya Fujii, Masahiro Tanabe, Katsuyoshi Ito, Takahiro Tsuboyama, Yuichiro Kanie, Shigeaki Umeoka, Shintaro Ichikawa, Utaroh Motosugi, Sayaka Daido, Ayumu Kido, Tsutomu Tamada, Mitsuru Matsuki, Tsuneo Yamashiro, Koichiro Yamakado

Published May 21, 2020 · Vol. 11, No. 40 · pp. 3675-3686

Keywords: cervical cancer, neuroendocrine carcinoma, small cell carcinoma, large cell carcinoma, MRI

Blood-based next-generation sequencing analysis of neuroendocrine neoplasms Research Paper

Katerina Zakka, Rebecca Nagy, Leylah Drusbosky, Mehmet Akce, Christina Wu, Olatunji B. Alese, Bassel F. El-Rayes, Pashtoon Murtaza Kasi, Kabir Mody, Jason Starr, Walid L. Shaib

Published Apr 26, 2020 · Vol. 11, No. 19 · pp. 1749-1757

Keywords: neuroendocrine neoplasm, neuroendocrine tumor, neuroendocrine carcinoma, next-generation sequencing, circulating tumor DNA

Clinical implications of chromatin accessibility in human cancers Research Paper

Yuexin Liu

Published Apr 22, 2020 · Vol. 11, No. 18 · pp. 1666-1678

Keywords: ATAC-seq, chromatin accessibility, TCGA, promoter, survival

Zebrafish B cell acute lymphoblastic leukemia: new findings in an old model Research Perspective

Gilseung Park, Jessica Burroughs-Garcia, Clay A. Foster, Ameera Hasan, Chiara Borga, J. Kimble Frazer

Published Apr 14, 2020 · Vol. 11, No. 15 · pp. 1292-1305

Keywords: acute lymphoblastic leukemia, ALL, zebrafish, lymphocyte, MYC

Gene expression dynamic analysis reveals co-activation of Sonic Hedgehog and epidermal growth factor followed by dynamic silencing Research Paper

Vahed Maroufy, Pankil Shah, Arvand Asghari, Nan Deng, Rosemarie N.U. Le, Juan C. Ramirez, Ashraf Yaseen, W. Jim Zheng, Michihisa Umetani, Hulin Wu

Published Apr 14, 2020 · Vol. 11, No. 15 · pp. 1358-1372

Keywords: pathway cross-talk, gene expression dynamics, gene regulatory network, Sonic Hedgehog, epidermal growth factor

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Phase I dose escalation study of 12b80 (hydroxybisphosphonate linked doxorubicin) in naturally occurring osteosarcoma Research Paper

HER2 splice variants in breast cancer: investigating their impact on diagnosis and treatment outcomes Review

Histo-molecular differentiation of renal cancer subtypes by mass spectrometry imaging and rapid proteome profiling of formalin-fixed paraffin-embedded tumor tissue sections Research Paper

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

PD-1/PD-L1 expression in anal squamous intraepithelial lesions Research Paper

A comprehensive analysis of clinical trials in pancreatic cancer: what is coming down the pike? Research Paper

Therapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin’s lymphoma to many other types of solid cancers Research Paper

Sequencing for an interdisciplinary molecular tumor board in patients with advanced breast cancer: experiences from a case series Research Paper

The NKL-code for innate lymphoid cells reveals deregulated expression of NKL homeobox genes HHEX and HLX in anaplastic large cell lymphoma (ALCL) Research Paper

Epigenetic feedback and stochastic partitioning during cell division can drive resistance to EMT Research Paper

Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation Research Paper

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

Profiling the circulating mRNA transcriptome in human liver disease Research Paper

Neuroendocrine carcinoma of uterine cervix findings shown by MRI for staging and survival analysis – Japan multicenter study Research Paper

Blood-based next-generation sequencing analysis of neuroendocrine neoplasms Research Paper

Clinical implications of chromatin accessibility in human cancers Research Paper

Zebrafish B cell acute lymphoblastic leukemia: new findings in an old model Research Perspective

Gene expression dynamic analysis reveals co-activation of Sonic Hedgehog and epidermal growth factor followed by dynamic silencing Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Phase I dose escalation study of 12b80 (hydroxybisphosphonate linked doxorubicin) in naturally occurring osteosarcoma Research Paper

HER2 splice variants in breast cancer: investigating their impact on diagnosis and treatment outcomes Review

Histo-molecular differentiation of renal cancer subtypes by mass spectrometry imaging and rapid proteome profiling of formalin-fixed paraffin-embedded tumor tissue sections Research Paper

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

PD-1/PD-L1 expression in anal squamous intraepithelial lesions Research Paper

A comprehensive analysis of clinical trials in pancreatic cancer: what is coming down the pike? Research Paper

Therapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin’s lymphoma to many other types of solid cancers Research Paper

Sequencing for an interdisciplinary molecular tumor board in patients with advanced breast cancer: experiences from a case series Research Paper

The NKL-code for innate lymphoid cells reveals deregulated expression of NKL homeobox genes HHEX and HLX in anaplastic large cell lymphoma (ALCL) Research Paper

Epigenetic feedback and stochastic partitioning during cell division can drive resistance to EMT Research Paper

Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation Research Paper

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

Profiling the circulating mRNA transcriptome in human liver disease Research Paper

Neuroendocrine carcinoma of uterine cervix findings shown by MRI for staging and survival analysis – Japan multicenter study Research Paper

Blood-based next-generation sequencing analysis of neuroendocrine neoplasms Research Paper

Clinical implications of chromatin accessibility in human cancers Research Paper

Zebrafish B cell acute lymphoblastic leukemia: new findings in an old model Research Perspective

Gene expression dynamic analysis reveals co-activation of Sonic Hedgehog and epidermal growth factor followed by dynamic silencing Research Paper