The Oncosearch | Oncotarget

Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

Hendrik Ungefroren, Susanne Sebens, Klaudia Giehl, Ole Helm, Stephanie Groth, Fred Faendrich, Christoph Roecken, Bence Sipos, Hendrik Lehnert, Frank Gieseler

Published Dec 23, 2013 · Vol. 5, No. 1 · pp. 277-290

Keywords: Rac1b, Rac1, Smad, TGF-beta1, pancreatic ductal adenocarcinoma, cell migration

Perspectives of TGF-Î² inhibition in pancreatic and hepatocellular carcinomas Review

Cindy Neuzillet, Armand de Gramont, AnnemilaÃ¯ Tijeras-Raballand, Louis de Mestier, JÃ©rÃ´me Cros, Sandrine Faivre, Eric Raymond

Published Dec 18, 2013 · Vol. 5, No. 1 · pp. 78-94

Keywords: SMAD, stellate cells, extracellular matrix, EMT, TGF-Î² inhibitors

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-ÎºB regulated gene products in multiple myeloma xenograft mouse model Research Paper

Kodappully Sivaraman Siveen, Nurulhuda Mustafa, Feng Li, Radhamani Kannaiyan, Kwang Seok Ahn, Alan Prem Kumar, Wee-Joo Chng, Gautam Sethi

Published Dec 18, 2013 · Vol. 5, No. 3 · pp. 634-648

Keywords: Thymoquinone, MM, bortezomib, apoptosis, NF-ÎºB

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

Zhongwu li, Yanling Wang, Jing Qiu, Qiang Li, Chunping Yuan, Wei Zhang, Dongmiao Wang, Jinhai Ye, Hongbin Jiang, Jianrong Yang, Jie Cheng

Published Dec 7, 2013 · Vol. 4, No. 12 · pp. 2532-2549

Keywords: tongue squamous cell carcinoma, polycomb complex, EZH2, DZNep

KrÃ¼ppel-like factors in cancer progression: three fingers on the steering wheel. Review

Ridha Limame, Ken Op de Beeck, Filip Lardon, Olivier De Wever, Patrick Pauwels

Published Nov 30, 2013 · Vol. 5, No. 1 · pp. 29-48

Keywords: KrÃ¼ppel-like factor, carcinoma, EMT, invasion, metastasis, pluripotency

Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer Research Paper

Gab-Yong Bae, So-Jung Choi, Ji-Seon Lee, Jisuk Jo, Jinseon Lee, Jhingook Kim, Hyuk-Jin Cha

Published Nov 29, 2013 · Vol. 4, No. 12 · pp. 2512-2522

Keywords: E-Cadherin, EGFR-MEK/ERK signaling, ZEB1, MMP2, Invasion

FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7 Research Paper

Zeran Wang, Yueyong Liu, Pengju Zhang, Weiguo Zhang, Weijing Wang, Kenneth Curr, Guangwei Wei, Jian-Hua Mao

Published Nov 25, 2013 · Vol. 4, No. 12 · pp. 2476-2486

Keywords: FAM83D, FBXW7, breast cancer, epithelial-mesenchymal transition, invasion

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

Alba Dalmases, Irene Gonzalez-Navarrete, Silvia Menendez, Oriol ArpÃ, Josep Maria Coromines, Sonia Servitja, Ignasi Tusquets, Cristina Chamizo, RaÃºl RincÃ³n, LluÃs Espinosa, Anna Bigas, Pilar Eroles, Jessica Furriol, Anna Lluch, Ana Rovira, Joan Albanell, Federico Rojo

Published Nov 23, 2013 · Vol. 5, No. 1 · pp. 196-210

Keywords: breast cancer, chemoresistance, NF-ÐºB, p53, prognosis

FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma Research Paper

Dan Li, Hong Mei, Meng Qi, Dehua Yang, Xiang Zhao, Xuan Xiang, Jiarui Pu, Kai Huang, Liduan Zheng, Qiangsong Tong

Published Nov 5, 2013 · Vol. 4, No. 11 · pp. 2021-2044

Aberrantly hypermethylated Homeobox A2 derepresses metalloproteinase-9 through TBP and promotes invasion in Nasopharyngeal carcinoma Research Paper

Hsin-Pai Li, Chen-Ching Peng, I-Che Chung, Mei-Yuan Huang, Shao-Tung Huang, Chia-Chun Chen, Kai-Ping Chang, Cheng-Lung Hsu, Yu-Sun Chang

Published Nov 4, 2013 · Vol. 4, No. 11 · pp. 2154-2165

Keywords: HOXA2, DNA methylation, NPC, MMP9

ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer Research Paper

Christian Holzmann, Tatiana Kilch, Sven Kappel, Andrea ArmbrÃ¼ster, Volker Jung, Michael StÃ¶ckle, Ivan Bogeski, Eva C Schwarz, Christine Peinelt

Published Oct 28, 2013 · Vol. 4, No. 11 · pp. 2096-2107

Keywords: Membrane androgen receptor, Orai channel, CRAC channel, prostate cancer, Ca2+ signaling

Induction and transport of Wnt 5a during macrophage-induced malignant invasion is mediated by two types of extracellular vesicles Research Paper

Kerstin Menck, Florian Klemm, Julia Christina Gross, Tobias Pukrop, Dirk Wenzel, Claudia Binder

Published Oct 21, 2013 · Vol. 4, No. 11 · pp. 2057-2066

Keywords: Breast cancer, exosomes, Evi, microvesicles, macrophages, Wnt 5a

NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals Research Paper

Sabine Becker-Weimann, Gaofeng Xiong, Saori Furuta, Ju Han, Irene Kuhn, Uri-David Akavia, Dana Pe'er, Mina J. Bissell, Ren Xu

Published Oct 14, 2013 · Vol. 4, No. 11 · pp. 2010-2020

Keywords: disorganization gene signature, p65, RelB, three-dimensional tissue structure, tissue polarity

Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway Research Paper

Qiong Wu, Rui Wang, Qingling Yang, Xin Hou, Sulian Chen, Yueyue Hou, Changjie Chen, Yan Yang, Lucio Miele, Fazlul Sarkar, Yuqing Chen, Zhiwei Wang

Published Oct 7, 2013 · Vol. 4, No. 11 · pp. 1999-2009

Keywords: Hepatocellular carcinoma, chemoresistance, PDGF-D, EMT, gemcitabine

Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway Research Paper

Seung-Hyun Hong, Sung-Ho Goh, Sang-Jin Lee, Jung-Ah Hwang, Jieun Lee, Il-Ju Choi, Hyehyun Seo, Jong-Hoon Park, Hiromu Suzuki, Eiichiro Yamamoto, In-Hoo Kim, Jin Sook Jeong, Mi Ha Ju, Dong-Hee Lee, Yeon-Su Lee

Published Sep 30, 2013 · Vol. 4, No. 10 · pp. 1791-1803

Keywords: gastric cancer, adenylate cyclase, tumorigenesis, cAMP/PKA/CREB pathway, promoter methylation

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Elena Kurenova, Jianqun Liao, Di-Hua He, Darrell Hunt, Michael Yemma, Wiam Bshara, Mukund Seshadri, William G Cance

Published Sep 30, 2013 · Vol. 4, No. 10 · pp. 1632-1646

Keywords: FAK Scaffold Inhibitor, pancreatic cancer, FAK-VEGFR-3 interaction, protein-protein interaction

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1 Research Paper

Maria Giovanna Francipane, Eric Lagasse

Published Sep 19, 2013 · Vol. 4, No. 11 · pp. 1948-1962

Keywords: colorectal cancer, cancer stem cells, mTOR, apoptosis

Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas Research Paper

Julia M. Fraile, Gonzalo R. OrdoÃ±ez, Pedro M. Quiros, Aurora Astudillo, Jose A. Galvan, Dolors Colomer, Carlos Lopez-Otin, Jose M.P. Freije, Xose S. Puente

Published Sep 15, 2013 · Vol. 4, No. 11 · pp. 1919-1932

Keywords: proteolysis, metastasis, invasion, cancer

Altered glycosylation of MUC1 influences its association with CIN85: the role of this novel complex in cancer cell invasion and migration Research Paper

Sandra Cascio, Adam M Farkas, Rebecca P Hughey, Olivera J Finn

Published Sep 7, 2013 · Vol. 4, No. 10 · pp. 1686-1697

Keywords: MUC1, CIN85, protein-protein interaction, cell migration, metastasis, novel targets, glycosylation

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper

Daniela Loetsch, Elisabeth Steiner, Klaus Holzmann, Sabine Spiegl-Kreinecker, Christine Pirker, Juraj Hlavaty, Helga Petznek, Balazs Hegedus, Tamas Garay, Thomas Mohr, Wolfgang Sommergruber, Walter Berger, Michael Grusch

Published Sep 1, 2013 · Vol. 4, No. 11 · pp. 1904-1918

Keywords: major vault protein, vault particles, glioblastoma multiforme, EGFR, PI3K, migration, invasion

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Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

Perspectives of TGF-Î² inhibition in pancreatic and hepatocellular carcinomas Review

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-ÎºB regulated gene products in multiple myeloma xenograft mouse model Research Paper

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

KrÃ¼ppel-like factors in cancer progression: three fingers on the steering wheel. Review

Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer Research Paper

FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7 Research Paper

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma Research Paper

Aberrantly hypermethylated Homeobox A2 derepresses metalloproteinase-9 through TBP and promotes invasion in Nasopharyngeal carcinoma Research Paper

ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer Research Paper

Induction and transport of Wnt 5a during macrophage-induced malignant invasion is mediated by two types of extracellular vesicles Research Paper

NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals Research Paper

Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway Research Paper

Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway Research Paper

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1 Research Paper

Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas Research Paper

Altered glycosylation of MUC1 influences its association with CIN85: the role of this novel complex in cancer cell invasion and migration Research Paper

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

Perspectives of TGF-Î² inhibition in pancreatic and hepatocellular carcinomas Review

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-ÎºB regulated gene products in multiple myeloma xenograft mouse model Research Paper

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

KrÃ¼ppel-like factors in cancer progression: three fingers on the steering wheel. Review

Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer Research Paper

FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7 Research Paper

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma Research Paper

Aberrantly hypermethylated Homeobox A2 derepresses metalloproteinase-9 through TBP and promotes invasion in Nasopharyngeal carcinoma Research Paper

ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer Research Paper

Induction and transport of Wnt 5a during macrophage-induced malignant invasion is mediated by two types of extracellular vesicles Research Paper

NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals Research Paper

Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway Research Paper

Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway Research Paper

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1 Research Paper

Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas Research Paper

Altered glycosylation of MUC1 influences its association with CIN85: the role of this novel complex in cancer cell invasion and migration Research Paper

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper