The Oncosearch | Oncotarget

Insights from yeast into whether the rapamycin inhibition of heat shock transcription factor (Hsf1) can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor Research Paper

Stefan H. Millson, Peter W. Piper

Published Jun 7, 2014 · Vol. 5, No. 13 · pp. 5054-5064

Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells Research Paper

Azusa Tanimoto, Tadaaki Yamada, Shigeki Nanjo, Shinji Takeuchi, Hiromichi Ebi, Kenji Kita, Kunio Matsumoto, Seiji Yano

Published Jun 3, 2014 · Vol. 5, No. 13 · pp. 4920-4928

Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer Research Paper

Xiaomei Qi, Congying Xie, Songwang Hou, Gang Li, Ning Yin, Lei Dong, Adrienne Lepp, Marla A. Chesnik, Shama P. Mirza, Aniko Szabo, Susan Tsai, Zainab Basir, Shixiu Wu, Guan Chen

Published May 25, 2014 · Vol. 5, No. 12 · pp. 4269-4282

Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer Research Paper

Seok-Jun Kim, Yuan-Guo Wang, Hyun-Woo Lee, Hyeok Gu Kang, Sun-Hyuk La, Il Ju Choi, Tatsuro Irimura, Jae Y. Ro, Robert S. Bresalier, Kyung-Hee Chun

Published May 13, 2014 · Vol. 5, No. 10 · pp. 3386-3398

Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells Research Paper

Young Eun Choi, Chiara Battelli, Jacqueline Watson, Joyce Liu, Jennifer Curtis, Alexander N. Morse, Ursula A. Matulonis, Dipanjan Chowdhury, Panagiotis A. Konstantinopoulos

Published Apr 30, 2014 · Vol. 5, No. 9 · pp. 2678-2687

Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression Research Paper

Eric A. Voll, Irene M. Ogden, Janet M. Pavese, XiaoKe Huang, Li Xu, Borko D. Jovanovic, Raymond C. Bergan

Published Apr 21, 2014 · Vol. 5, No. 9 · pp. 2648-2663

CHIP is a novel tumor suppressor in pancreatic cancer and inhibits tumor growth through targeting EGFR Research Paper

Tianxiao Wang, Jingxuan Yang, Jianwei Xu, Jian Li, Zhe Cao, Li Zhou, Lei You, Hong Shu, Zhaohui Lu, Huihua Li, Min Li, Taiping Zhang, Yupei Zhao

Published Apr 8, 2014 · Vol. 5, No. 7 · pp. 1969-1986

Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma Research Paper

Ming-Huang Chen, Kun-Chun Chiang, Chi-Tung Cheng, Shih-Chiang Huang, Yeng-Yang Chen, Tsung-Wen Chen, Ta-Sen Yeh, Yi-Yin Jan, Hsi-Ming Wang, Jiang-Jie Weng, Peter Mu-Hsin Chang, Chun-Yu Liu, Chung-Pin Li, Yee Chao, Ming-Han Chen, Chi-Ying F. Huang, Chun-Nan Yeh

Published Mar 26, 2014 · Vol. 5, No. 9 · pp. 2372-2389

Keywords: NVP-AUY922, NVP-BEZ235, heat-shock protein 90, phosphatase and tensin homolog

Exogenously delivered heat shock protein 70 displaces its endogenous analogue and sensitizes cancer cells to lymphocytes-mediated cytotoxicity Research Paper

Maxim A. Shevtsov, Elena Y. Komarova, Darya A. Meshalkina, Natalia V. Bychkova, Nikolai D. Aksenov, Sergey V. Abkin, Boris A. Margulis, Irina V. Guzhova

Published Mar 22, 2014 · Vol. 5, No. 10 · pp. 3101-3114

Identification of heat shock protein 32 (Hsp32) as a novel target in acute lymphoblastic leukemia Priority Research Paper

Sabine Cerny-Reiterer, Renata A. Meyer, Harald Herrmann, Barbara Peter, Karoline V. Gleixner, Gabriele Stefanzl, Emir Hadzijusufovic, Winfried F. Pickl, Wolfgang R. Sperr, Junia V. Melo, Hiroshi Maeda, Ulrich JÃ¤ger, Peter Valent

Published Mar 4, 2014 · Vol. 5, No. 5 · pp. 1198-1211

Heat shock proteins in multiple myeloma Review

Lei Zhang, Jacqueline H.L. Fok, Faith E. Davies

Published Jan 19, 2014 · Vol. 5, No. 5 · pp. 1132-1148

Keywords: heat shock proteins, multiple myeloma, protein folding, ER stress, haematology

Quantitative proteomic analysis reveals potential diagnostic markers and pathways involved in pathogenesis of renal cell carcinoma Research Paper

Nicole M.A. White, Olena Masui, Leroi V. DeSouza, Olga Krakovska, Shereen Metias, Alexander D. Romaschin, R.John Honey, Robert Stewart, Kenneth Pace, Jason Lee, Michael AS. Jewett, Georg A. Bjarnason, K.W.Michael Siu, George M. Yousef

Published Jan 18, 2014 · Vol. 5, No. 2 · pp. 506-518

Keywords: kidney cancer, renal cell, carcinoma, iTRAQ, proteomics, Hsp27, urine markers

Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy Research Paper

Weiguo Wang, Weidan Ji, Huanzhang Hu, Juming Ma, Xiaoya Li, Weiqun Mei, Yang Xu, Hui-Zhen Hu, Yan Yan, Qizhe Song, Zhigang Li, Changqing Su

Published Dec 28, 2013 · Vol. 5, No. 1 · pp. 150-160

Keywords: Gastric cancer, Survivin gene, Heat shock protein, Oncolytic adenovirus, Gene therapy

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Marissa V Powers, Melanie Valenti, Susana Mirander, Alison Maloney, Suzanne A Eccles, George Thomas, Paul A Clarke, Paul Workman

Published Sep 29, 2013 · Vol. 4, No. 11 · pp. 1963-1975

Keywords: 17-AAG, HSP90, BAX, Apoptosis, Colon cancer

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine Research Paper

Duane H. Hamilton, Mary T. Litzinger, Alessandra Jales, Bruce Huang, Romaine I. Fernando, James W. Hodge, Andressa Ardiani, David Apelian, Jeffrey Schlom, Claudia Palena

Published Sep 26, 2013 · Vol. 4, No. 10 · pp. 1777-1790

Keywords: epithelial-mesenchymal transition, brachyury, T-box transcription factor, cancer vaccine, T-cell immunotherapy

Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors Research Paper

Kristin Beebe, Mehdi Mollapour, Bradley Scroggins, Chrisostomos Prodromou, Wanping Xu, Mari Tokita, Tony Taldone, Lester Pullen, Bettina K Zierer, Min-Jung Lee, Jane Trepel, Johannes Buchner, Daniel Bolon, Gabriela Chiosis, Len Neckers

Published Jul 7, 2013 · Vol. 4, No. 7 · pp. 1065-1074

Keywords: Hsp90, posttranslational modification, phosphorylation, drug binding, Hsp90 inhibitor

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition Research Paper

Yaoyu Chen, Jinyun Chen, Alice Loo, Savina Jaeger, Linda Bagdasarian, Jianjun Yu, Franklin Chung, Joshua Korn, David Ruddy, Ribo Guo, Margaret Mclaughlin, Fei Feng, Ping Zhu, Frank Stegmeier, Raymond Pagliarini, Dale Porter, Wenlai Zhou

Published Apr 23, 2013 · Vol. 4, No. 6 · pp. 816-829

Keywords: HSF1, cancer cells, HSP90 inhibitor, Melanoma, HCC, DEDD2

Heat Shock Protein 90 is overexpressed in high-risk myelodysplastic syndromes and associated with higher expression and activation of Focal Adhesion Kinase Research Paper

Pascale Flandrin-Gresta, Francoise Solly, Carmen Mariana Aanei, Jerome Cornillon, Emmanuelle Tavernier, Nathalie Nadal, Franck Morteux, Denis Guyotat, Eric Wattel, Lydia Campos

Published Sep 28, 2012 · Vol. 3, No. 10 · pp. 1158-1168

Keywords: HSP90, myelodysplasic syndrome, AKT, FAK

Shock about heat shock in cancer Special Feature

Emmanuel de Billy, Jon Travers, Paul Workman

Published Aug 30, 2012 · Vol. 3, No. 8 · pp. 741-743

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-ÎºB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells Research Paper

Elisabeth J. Walsby, Laurence Pearce, Alan K. Burnett, Chris Fegan, Chris Pepper

Published May 19, 2012 · Vol. 3, No. 5 · pp. 525-534

Keywords: Hsp90, CLL, apoptosis, synergy, NF-ÎºB

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Insights from yeast into whether the rapamycin inhibition of heat shock transcription factor (Hsf1) can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor Research Paper

Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells Research Paper

Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer Research Paper

Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer Research Paper

Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells Research Paper

Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression Research Paper

CHIP is a novel tumor suppressor in pancreatic cancer and inhibits tumor growth through targeting EGFR Research Paper

Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma Research Paper

Exogenously delivered heat shock protein 70 displaces its endogenous analogue and sensitizes cancer cells to lymphocytes-mediated cytotoxicity Research Paper

Identification of heat shock protein 32 (Hsp32) as a novel target in acute lymphoblastic leukemia Priority Research Paper

Heat shock proteins in multiple myeloma Review

Quantitative proteomic analysis reveals potential diagnostic markers and pathways involved in pathogenesis of renal cell carcinoma Research Paper

Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy Research Paper

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine Research Paper

Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors Research Paper

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition Research Paper

Heat Shock Protein 90 is overexpressed in high-risk myelodysplastic syndromes and associated with higher expression and activation of Focal Adhesion Kinase Research Paper

Shock about heat shock in cancer Special Feature

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-ÎºB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Insights from yeast into whether the rapamycin inhibition of heat shock transcription factor (Hsf1) can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor Research Paper

Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells Research Paper

Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer Research Paper

Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer Research Paper

Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells Research Paper

Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression Research Paper

CHIP is a novel tumor suppressor in pancreatic cancer and inhibits tumor growth through targeting EGFR Research Paper

Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma Research Paper

Exogenously delivered heat shock protein 70 displaces its endogenous analogue and sensitizes cancer cells to lymphocytes-mediated cytotoxicity Research Paper

Identification of heat shock protein 32 (Hsp32) as a novel target in acute lymphoblastic leukemia Priority Research Paper

Heat shock proteins in multiple myeloma Review

Quantitative proteomic analysis reveals potential diagnostic markers and pathways involved in pathogenesis of renal cell carcinoma Research Paper

Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy Research Paper

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine Research Paper

Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors Research Paper

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition Research Paper

Heat Shock Protein 90 is overexpressed in high-risk myelodysplastic syndromes and associated with higher expression and activation of Focal Adhesion Kinase Research Paper

Shock about heat shock in cancer Special Feature

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-ÎºB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells Research Paper