The Oncosearch | Oncotarget

RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients Clinical Research Papers

Talia Golan, Elina Zorde Khvalevsky, Ayala Hubert, Rachel Malka Gabai, Naama Hen, Amiel Segal, Abraham Domb, Gil Harari, Eliel Ben David, Stephen Raskin, Yuri Goldes, Eran Goldin, Rami Eliakim, Maor Lahav, Yael Kopleman, Alain Dancour, Amotz Shemi, Eithan Galun

Published May 19, 2015 · Vol. 6, No. 27 · pp. 24560-24570

MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine Research Paper

Chen Liang, Xian-Jun Yu, Xiao-Zhong Guo, Meng-Hong Sun, Zhen Wang, Yao Song, Quan-Xing Ni, Hong-Yu Li, Naofumi Mukaida, Ying-Yi Li

Published May 8, 2015 · Vol. 6, No. 16 · pp. 14440-14455

Gemcitabine triggers angiogenesis-promoting molecular signals in pancreatic cancer cells: Therapeutic implications Research Paper

Mohammad Aslam Khan, Sanjeev K. Srivastava, Arun Bhardwaj, Seema Singh, Sumit Arora, Haseeb Zubair, James E. Carter, Ajay P. Singh

Published Apr 23, 2015 · Vol. 6, No. 36 · pp. 39140-39150

Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress Research Paper

Priyanka Saini, Yizhu Li, Matthias Dobbelstein

Published Apr 19, 2015 · Vol. 6, No. 15 · pp. 13072-13087

The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2 Research Paper

Nicolas Skrypek, Romain Vasseur, Audrey Vincent, BÃ©linda DuchÃªne, Isabelle Van Seuningen, Nicolas Jonckheere

Published Mar 26, 2015 · Vol. 6, No. 13 · pp. 10853-10867

Combination of carbon ion beam and gemcitabine causes irreparable DNA damage and death of radioresistant pancreatic cancer stem-like cells in vitro and in vivo Research Perspective

Sei Sai, Toshifumi Wakai, Guillaume Vares, Shigeru Yamada, Takehiko Kamijo, Tadashi Kamada, Toshiyuki Shirai

Published Mar 14, 2015 · Vol. 6, No. 8 · pp. 5517-5535

Prognostic factors of survival in patients treated with nab-paclitaxel plus gemcitabine regimen for advanced or metastatic pancreatic cancer: A single institutional experience Research Paper

Giovanni Lo Re, Davide A Santeufemia, Luisa Foltran, Ettore Bidoli, Stefano M.M. Basso, Franco Lumachi

Published Mar 10, 2015 · Vol. 6, No. 10 · pp. 8255-8260

Dual targeting of HER1/EGFR and HER2 with cetuximab and trastuzumab in patients with metastatic pancreatic cancer after gemcitabine failure: results of the â€œTHERAPYâ€phase 1-2 trial Clinical Research Papers

Eric Assenat, David Azria, Caroline Mollevi, Rosine Guimbaud, Nicole Tubiana-Mathieu, Denis Smith, Jean-Pierre Delord, Emmanuelle Samalin, Fabienne Portales, Christel Larbouret, Bruno Robert, FrÃ©dÃ©ric Bibeau, Jean-Pierre Bleuse, Evelyne Crapez, Marc Ychou, AndrÃ© PÃ¨legrin

Published Feb 28, 2015 · Vol. 6, No. 14 · pp. 12796-12808

The PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cells Research Paper

Rui Wang, Yumei Li, Yueyue Hou, Qingling Yang, Sulian Chen, Xi Wang, Zishu Wang, Yan Yang, Changjie Chen, Zhiwei Wang, Qiong Wu

Published Feb 11, 2015 · Vol. 6, No. 9 · pp. 7000-7010

Aspirin counteracts cancer stem cell features, desmoplasia and gemcitabine resistance in pancreatic cancer Research Paper

Yiyao Zhang, Li Liu, Pei Fan, Nathalie Bauer, Jury Gladkich, Eduard Ryschich, Alexandr V. Bazhin, Nathalia A. Giese, Oliver Strobel, Thilo Hackert, Ulf Hinz, Wolfgang Gross, Franco Fortunato, Ingrid Herr

Published Feb 5, 2015 · Vol. 6, No. 12 · pp. 9999-10015

Identification of PAM4 (clivatuzumab)-reactive epitope on MUC5AC: A promising biomarker and therapeutic target for pancreatic cancer Research Paper

Donglin Liu, Chien-Hsing Chang, David V. Gold, David M. Goldenberg

Published Jan 19, 2015 · Vol. 6, No. 6 · pp. 4274-4285

Keywords: MUC5AC, epitope mapping, PAM4, pancreatic cancer, cysteine-rich subdomain

Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells Research Paper

Jia Ma, Binbin Fang, Fanpeng Zeng, Cong Ma, Haijie Pang, Long Cheng, Ying Shi, Hui Wang, Bin Yin, Jun Xia, Zhiwei Wang

Published Dec 31, 2014 · Vol. 6, No. 3 · pp. 1740-1749

Keywords: Gemcitabine, miR-223, EMT, invasion, pancreatic cancer.

The heparan sulfate mimetic PG545 interferes with Wnt/Î²-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine Research Paper

Deok-Beom Jung, Miyong Yun, Eun-Ok Kim, Jaekwang Kim, Bonglee Kim, Ji Hoon Jung, Enfeng Wang, Debabrata Mukhopadhyay, Edward Hammond, Keith Dredge, Viji Shridhar, Sung-Hoon Kim

Published Dec 31, 2014 · Vol. 6, No. 7 · pp. 4992-5004

Paracrine SDF-1Î± signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells Research Paper

Hui Zhang, Huanwen Wu, Jian Guan, Li Wang, Xinyu Ren, Xiaohua Shi, Zhiyong Liang, Tonghua Liu

Published Dec 30, 2014 · Vol. 6, No. 5 · pp. 3085-3097

Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells Priority Research Paper

Franziska Schmidt, Meike Kunze, Ann-Christine Loock, Matthias Dobbelstein

Published Dec 15, 2014 · Vol. 6, No. 2 · pp. 617-632

Keywords: DNA damage, cisplatin, gemcitabine, siRNA screen, ubiquitin ligase, G2E3, Chk1

Inhibition of HIF-1Î± by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma Research Paper

Tiansuo Zhao, He Ren, Li Jia, Jing Chen, Wen Xin, Fan Yan, Jing Li, Xiuchao Wang, Song Gao, Dong Qian, Chongbiao Huang, Jihui Hao

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2250-2262

JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells Research Paper

Shuhei Suzuki, Masashi Okada, Keita Shibuya, Manabu Seino, Atsushi Sato, Hiroyuki Takeda, Shizuka Seino, Takashi Yoshioka, Chifumi Kitanaka

Published Nov 19, 2014 · Vol. 6, No. 1 · pp. 458-470

Keywords: cancer initiating cells, chemotherapy, combination therapy, c-Jun N-terminal kinase

Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer Priority Research Paper

Catherine Burkhart, Daria Fleyshman, Rachael Kohrn, Mairead Commane, Jennifer Garrigan, Vadim Kurbatov, Ilya Toshkov, Rajesh Ramachandran, Laura Martello, Katerina V. Gurova

Published Nov 6, 2014 · Vol. 5, No. 22 · pp. 11038-11053

Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models Research Paper

Yukihiko Hiroshima, Yong Zhang, Takashi Murakami, Ali Maawy, Shinji Miwa, Mako Yamamoto, Shuya Yano, Sho Sato, Masashi Momiyama, Ryutaro Mori, Ryusei Matsuyama, Takashi Chishima, Kuniya Tanaka, Yasushi Ichikawa, Michael Bouvet, Itaru Endo, Ming Zhao, Robert M. Hoffman

Published Oct 28, 2014 · Vol. 5, No. 23 · pp. 12346-12357

MicroRNA-145 targets MUC13 and suppresses growth and invasion of pancreatic cancer Research Paper

Sheema Khan, Mara C. Ebeling, Mohd S. Zaman, Mohammed Sikander, Murali M. Yallapu, Neeraj Chauhan, Ashley M. Yacoubian, Stephen W. Behrman, Nadeem Zafar, Deepak Kumar, Paul A. Thompson, Meena Jaggi, Subhash C. Chauhan

Published Jul 30, 2014 · Vol. 5, No. 17 · pp. 7599-7609

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RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients Clinical Research Papers

MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine Research Paper

Gemcitabine triggers angiogenesis-promoting molecular signals in pancreatic cancer cells: Therapeutic implications Research Paper

Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress Research Paper

The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2 Research Paper

Combination of carbon ion beam and gemcitabine causes irreparable DNA damage and death of radioresistant pancreatic cancer stem-like cells in vitro and in vivo Research Perspective

Prognostic factors of survival in patients treated with nab-paclitaxel plus gemcitabine regimen for advanced or metastatic pancreatic cancer: A single institutional experience Research Paper

Dual targeting of HER1/EGFR and HER2 with cetuximab and trastuzumab in patients with metastatic pancreatic cancer after gemcitabine failure: results of the â€œTHERAPYâ€phase 1-2 trial Clinical Research Papers

The PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cells Research Paper

Aspirin counteracts cancer stem cell features, desmoplasia and gemcitabine resistance in pancreatic cancer Research Paper

Identification of PAM4 (clivatuzumab)-reactive epitope on MUC5AC: A promising biomarker and therapeutic target for pancreatic cancer Research Paper

Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells Research Paper

The heparan sulfate mimetic PG545 interferes with Wnt/Î²-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine Research Paper

Paracrine SDF-1Î± signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells Research Paper

Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells Priority Research Paper

Inhibition of HIF-1Î± by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma Research Paper

JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells Research Paper

Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer Priority Research Paper

Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models Research Paper

MicroRNA-145 targets MUC13 and suppresses growth and invasion of pancreatic cancer Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients Clinical Research Papers

MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine Research Paper

Gemcitabine triggers angiogenesis-promoting molecular signals in pancreatic cancer cells: Therapeutic implications Research Paper

Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress Research Paper

The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2 Research Paper

Combination of carbon ion beam and gemcitabine causes irreparable DNA damage and death of radioresistant pancreatic cancer stem-like cells in vitro and in vivo Research Perspective

Prognostic factors of survival in patients treated with nab-paclitaxel plus gemcitabine regimen for advanced or metastatic pancreatic cancer: A single institutional experience Research Paper

Dual targeting of HER1/EGFR and HER2 with cetuximab and trastuzumab in patients with metastatic pancreatic cancer after gemcitabine failure: results of the â€œTHERAPYâ€phase 1-2 trial Clinical Research Papers

The PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cells Research Paper

Aspirin counteracts cancer stem cell features, desmoplasia and gemcitabine resistance in pancreatic cancer Research Paper

Identification of PAM4 (clivatuzumab)-reactive epitope on MUC5AC: A promising biomarker and therapeutic target for pancreatic cancer Research Paper

Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells Research Paper

The heparan sulfate mimetic PG545 interferes with Wnt/Î²-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine Research Paper

Paracrine SDF-1Î± signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells Research Paper

Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells Priority Research Paper

Inhibition of HIF-1Î± by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma Research Paper

JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells Research Paper

Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer Priority Research Paper

Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models Research Paper

MicroRNA-145 targets MUC13 and suppresses growth and invasion of pancreatic cancer Research Paper

Dual targeting of HER1/EGFR and HER2 with cetuximab and trastuzumab in patients with metastatic pancreatic cancer after gemcitabine failure: results of the â€œTHERAPYâ€phase 1-2 trial Clinical Research Papers