The Oncosearch | Oncotarget

Lapatinib induces autophagic cell death and inhibits growth of human hepatocellular carcinoma Research Paper

Yu-Jen Chen, Chih-Wen Chi, Wen-Chi Su, Huey-Lan Huang

Published May 31, 2014 · Vol. 5, No. 13 · pp. 4845-4854

The localization of HER4 intracellular domain and expression of its alternately-spliced isoforms have prognostic significance in ER+ HER2- breast cancer Research Paper

Saori Fujiwara, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Satoko Yamamoto, Mai Tomiguchi, Takashi Takeshita, Mitsuhiro Hayashi, Aiko Sueta, Hirotaka Iwase

Published May 28, 2014 · Vol. 5, No. 11 · pp. 3919-3930

Loss of EGFR signaling-regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance Research Paper

Man Kit Siu, Wassim Abou-Kheir, Juan Juan Yin, Yung-Sheng Chang, Ben Barrett, Florent Suau, Orla Casey, Wei-Yu Chen, Lei Fang, Paul Hynes, Yao-Yu Hsieh, Yen-Nien Liu, Jiaoti Huang, Kathleen Kelly

Published May 20, 2014 · Vol. 5, No. 11 · pp. 3770-3784

ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer Research Paper

Katharina Feldinger, Daniele Generali, Gabriela Kramer-Marek, Merel Gijsen, Tzi Bun Ng, Jack Ho Wong, Carla Strina, Mariarosa Cappelletti, Daniele Andreis, Ji-Liang Li, Esther Bridges, Helen Turley, Russell Leek, Ioannis Roxanis, Jacek Capala, Gillian Murphy, Adrian L. Harris, Anthony Kong

Published May 8, 2014 · Vol. 5, No. 16 · pp. 6633-6646

Identification of kit^M541L somatic mutation in chronic eosinophilic leukemia, not otherwise specified and its implication in low-dose imatinib response Clinical Research Papers

Alessandra Iurlo, Umberto Gianelli, Alessandro Beghini, Orietta Spinelli, Nicola Orofino, Francesca Lazzaroni, Stefano Cambiaghi, Tamara Intermesoli, Alessandro Rambaldi, Agostino Cortelezzi

Published May 1, 2014 · Vol. 5, No. 13 · pp. 4665-4670

Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer Research Paper

Siti Norasikin Mohd Nafi, Daniele Generali, Gabriela Kramer-Marek, Merel Gijsen, Carla Strina, Mariarosa Cappelletti, Daniele Andreis, Syed Haider, Ji-Liang Li, Esther Bridges, Jacek Capala, Roxanis Ioannis, Adrian L. Harris, Anthony Kong

Published Apr 17, 2014 · Vol. 5, No. 15 · pp. 5934-5949

CHIP is a novel tumor suppressor in pancreatic cancer and inhibits tumor growth through targeting EGFR Research Paper

Tianxiao Wang, Jingxuan Yang, Jianwei Xu, Jian Li, Zhe Cao, Li Zhou, Lei You, Hong Shu, Zhaohui Lu, Huihua Li, Min Li, Taiping Zhang, Yupei Zhao

Published Apr 8, 2014 · Vol. 5, No. 7 · pp. 1969-1986

p63 transcriptionally regulates the expression of matrix metallopeptidase 13 Research Paper

Ivana Celardo, Alexey Antonov, Ivano Amelio, Margherita Annicchiarico-Petruzzelli, Gerry Melino

Published Mar 15, 2014 · Vol. 5, No. 5 · pp. 1279-1289

Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma Priority Research Paper

Jie Li, Shan Zhu, David Kozono, Kimberly Ng, Diahnn Futalan, Ying Shen, Johnny C. Akers, Tyler Steed, Deepa Kushwaha, Michael Schlabach, Bob S. Carter, Chang-Hyuk Kwon, Frank Furnari, Webster Cavenee, Stephen Elledge, Clark C. Chen

Published Mar 7, 2014 · Vol. 5, No. 4 · pp. 882-893

FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway Research Paper

Janani Ravi, Amita Sneh, Konstantin Shilo, Mohd W. Nasser, Ramesh K. Ganju

Published Feb 21, 2014 · Vol. 5, No. 9 · pp. 2475-2486

Keywords: NSCLC, EGFR, Met-F-AEA, FAAH

Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells Research Paper

Jingjie Zhang, Guangxun Gao, Liang Chen, Jingxia Li, Xu Deng, Qin-shi Zhao, Chuanshu Huang

Published Feb 14, 2014 · Vol. 5, No. 3 · pp. 841-852

Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition Research Paper

Chueh-Chuan Yen, Chung-Der Hsiao, Wei-Ming Chen, Yao-Shan Wen, Yung-Chan Lin, Ting-Wei Chang, Fang-Yi Yao, Shih-Chieh Hung, Jir-You Wang, Jen-Hwey Chiu, Hsei-Wei Wang, Chi-Hung Lin, Tain-Hsiung Chen, Paul Chih-Hsueh Chen, Chien-Lin Liu, Cheng-Hwai Tzeng, Jonathan A. Fletcher

Published Jan 21, 2014 · Vol. 5, No. 3 · pp. 716-725

Keywords: 15d-PGJ2, AKT, PLK1, osteosarcoma

EGFR endocytosis is a novel therapeutic target in lung cancer with wild-type EGFR Research Paper

Ukhyun Jo, Kyong Hwa Park, Young Mi Whang, Jae Sook Sung, Nam Hee Won, Jong Kuk Park, Yeul Hong Kim

Published Jan 16, 2014 · Vol. 5, No. 5 · pp. 1265-1278

Keywords: EGFR, endocytosis, gefitinib, lung cancer, Rab25

Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells Research Paper

Kai Wu, Qingshan Chang, Yongju Lu, Ping Qiu, Bailing Chen, Chitra Thakur, Jiaying Sun, Lingzhi Li, Anjaneyulu Kowluru, Fei Chen

Published Nov 24, 2013 · Vol. 4, No. 12 · pp. 2430-2438

Keywords: Gefitinib, EGFR, STAT3, Akt recovery

COX-2 overexpression increases malignant potential of human glioma cells through Id1 Research Paper

Kaiming Xu, Lanfang Wang, Hui-Kuo G. Shu

Published Oct 31, 2013 · Vol. 5, No. 5 · pp. 1241-1252

Keywords: glioblastoma, brain tumor, tumorigenesis, cyclooxygenase-2, Id1

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper

Daniela Loetsch, Elisabeth Steiner, Klaus Holzmann, Sabine Spiegl-Kreinecker, Christine Pirker, Juraj Hlavaty, Helga Petznek, Balazs Hegedus, Tamas Garay, Thomas Mohr, Wolfgang Sommergruber, Walter Berger, Michael Grusch

Published Sep 1, 2013 · Vol. 4, No. 11 · pp. 1904-1918

Keywords: major vault protein, vault particles, glioblastoma multiforme, EGFR, PI3K, migration, invasion

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

Xiaoli Wu, Mihir K. Bhayani, Cristina T. Dodge, Milena S. Nicoloso, Yunyun Chen, Xiaofeng Yan, Makoto Adachi, Ligy Thomas, Chad E. Galer, Tilahun Jiffar, Curtis R. Pickering, Michael E. Kupferman, Jeffrey N. Myers, George A. Calin, Stephen Y. Lai

Published Aug 6, 2013 · Vol. 4, No. 9 · pp. 1388-1398

Keywords: miRNA EGFR AKT1 mTOR miRNA-27a* miRNA-27a-5p

Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer Research Paper

Alexandra Canonici, Merel Gijsen, Maeve Mullooly, Ruth Bennett, Noujoude Bouguern, Kasper Pedersen, Neil A Oâ€™Brien, Ioannis Roxanis, Ji-Liang Li, Esther Bridge, Richard Finn, Dennis Slamon, Patricia McGowan, Michael J. Duffy, Norma Oâ€™Donovan, John Crown, Anthony Kong

Published Jul 25, 2013 · Vol. 4, No. 10 · pp. 1592-1605

Keywords: breast cancer, HER2/ErbB2, trastuzumab (Herceptin), neratinib, panHER inhibitor

Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer Research Paper

Ke Chen, Kongming Wu, Michael Gormley, Adam Ertel, Wei Zhang, Jie Zhou, Gabriele DiSante, Zhiping Li, Hallgeir Rui, Andrew A. Quong, Steven B. McMahon, Haiteng Deng, Michael P. Lisanti, Chenguang Wang, Richard G. Pestell

Published Jun 21, 2013 · Vol. 4, No. 6 · pp. 923-935

Keywords: p53, breast cancer, cell fate, stem cells, dach

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Up-regulates Interleukin-6 in Cancer Cells and Induces Subsequent Development of Interstitial Pneumonia Research Paper

Yukari Ishiguro, Hitoshi Ishiguro, Hiroshi Miyamoto

Published Mar 31, 2013 · Vol. 4, No. 4 · pp. 550-559

Keywords: fibrosis, EGFR-TKI, IL-6, cytokine, side-effect

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Lapatinib induces autophagic cell death and inhibits growth of human hepatocellular carcinoma Research Paper

The localization of HER4 intracellular domain and expression of its alternately-spliced isoforms have prognostic significance in ER+ HER2- breast cancer Research Paper

Loss of EGFR signaling-regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance Research Paper

ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer Research Paper

Identification of kit^M541L somatic mutation in chronic eosinophilic leukemia, not otherwise specified and its implication in low-dose imatinib response Clinical Research Papers

Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer Research Paper

CHIP is a novel tumor suppressor in pancreatic cancer and inhibits tumor growth through targeting EGFR Research Paper

p63 transcriptionally regulates the expression of matrix metallopeptidase 13 Research Paper

Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma Priority Research Paper

FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway Research Paper

Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells Research Paper

Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition Research Paper

EGFR endocytosis is a novel therapeutic target in lung cancer with wild-type EGFR Research Paper

Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells Research Paper

COX-2 overexpression increases malignant potential of human glioma cells through Id1 Research Paper

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer Research Paper

Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer Research Paper

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Up-regulates Interleukin-6 in Cancer Cells and Induces Subsequent Development of Interstitial Pneumonia Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Lapatinib induces autophagic cell death and inhibits growth of human hepatocellular carcinoma Research Paper

The localization of HER4 intracellular domain and expression of its alternately-spliced isoforms have prognostic significance in ER+ HER2- breast cancer Research Paper

Loss of EGFR signaling-regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance Research Paper

ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer Research Paper

Identification of kitM541L somatic mutation in chronic eosinophilic leukemia, not otherwise specified and its implication in low-dose imatinib response Clinical Research Papers

Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer Research Paper

CHIP is a novel tumor suppressor in pancreatic cancer and inhibits tumor growth through targeting EGFR Research Paper

p63 transcriptionally regulates the expression of matrix metallopeptidase 13 Research Paper

Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma Priority Research Paper

FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway Research Paper

Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells Research Paper

Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition Research Paper

EGFR endocytosis is a novel therapeutic target in lung cancer with wild-type EGFR Research Paper

Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells Research Paper

COX-2 overexpression increases malignant potential of human glioma cells through Id1 Research Paper

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer Research Paper

Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer Research Paper

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Up-regulates Interleukin-6 in Cancer Cells and Induces Subsequent Development of Interstitial Pneumonia Research Paper

Identification of kit^M541L somatic mutation in chronic eosinophilic leukemia, not otherwise specified and its implication in low-dose imatinib response Clinical Research Papers