The Oncosearch | Oncotarget

Efficacy of osimertinib against EGFRvIII+ glioblastoma Research Paper

Gustavo Chagoya, Shawn G. Kwatra, Cory W. Nanni, Callie M. Roberts, Samantha M. Phillips, Sarah Nullmeyergh, Samuel P. Gilmore, Ivan Spasojevic, David L. Corcoran, Christopher C. Young, Karla V. Ballman, Rohan Ramakrishna, Darren A. Cross, James M. Markert, Michael Lim, Mark R. Gilbert, Glenn J. Lesser, Madan M. Kwatra

Published May 5, 2020 · Vol. 11, No. 22 · pp. 2074-2082

Keywords: EGFRvIII, tyrosine kinase, glioblastoma stem cells, osimertinib, xenografts

A 3D biofabricated cutaneous squamous cell carcinoma tissue model with multi-channel confocal microscopy imaging biomarkers to quantify antitumor effects of chemotherapeutics in tissue Research Paper

James R. Browning, Paige Derr, Kristy Derr, Nicole Doudican, Sam Michael, Samantha R. Lish, Nicholas A. Taylor, James G. Krueger, Marc Ferrer, John A. Carucci, Daniel S. Gareau

Published Apr 16, 2020 · Vol. 11, No. 27 · pp. 2587-2596

Keywords: squamous cell carcinoma, screening, 3D printing, in vitro model, confocal microscopy

Gene expression dynamic analysis reveals co-activation of Sonic Hedgehog and epidermal growth factor followed by dynamic silencing Research Paper

Vahed Maroufy, Pankil Shah, Arvand Asghari, Nan Deng, Rosemarie N.U. Le, Juan C. Ramirez, Ashraf Yaseen, W. Jim Zheng, Michihisa Umetani, Hulin Wu

Published Apr 14, 2020 · Vol. 11, No. 15 · pp. 1358-1372

Keywords: pathway cross-talk, gene expression dynamics, gene regulatory network, Sonic Hedgehog, epidermal growth factor

Pirfenidone anti-fibrotic effects are partially mediated by the inhibition of MUC1 bioactivation Research Paper

Beatriz Ballester, Javier Milara, Julio Cortijo

Published Apr 14, 2020 · Vol. 11, No. 15 · pp. 1306-1320

Keywords: pirfenidone, idiopathic pulmonary fibrosis, MUC1, transforming growth factor beta-1, fibroblasts

Early prediction of resistance to tyrosine kinase inhibitors by plasma monitoring of EGFR mutations in NSCLC: a new algorithm for patient selection and personalized treatment Research Paper

Fiamma Buttitta, Lara Felicioni, Alessia Di Lorito, Alessio Cortellini, Luciana Irtelli, Davide Brocco, Pietro Di Marino, Donatella Traisci, Nicola D’Ostilio, Alessandra Di Paolo, Francesco Malorgio, Pasquale Assalone, Sonia Di Felice, Francesca Fabbri, Giovanni Cianci, Michele De Tursi, Antonio Marchetti

Published Mar 17, 2020 · Vol. 11, No. 11 · pp. 982-991

Keywords: epidermal growth factor receptor (EGFR), tyrosine-kinase Inhibitors, circulating tumor-DNA (ct-DNA), massive parallel sequencing (MPS), resistance-inducing mutation

Risk factors for breast cancer brain metastases: a systematic review Review

Lola Koniali, Andreas Hadjisavvas, Anastasia Constantinidou, Kyproula Christodoulou, Yiolanda Christou, Christiana Demetriou, Andreas S. Panayides, Constantinos Pitris, Constantinos S. Pattichis, Eleni Zamba-Papanicolaou, Kyriacos Kyriacou

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 650-669

Keywords: breast cancer, brain metastases, risk factors, biomarkers

Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response Research Paper

James Jabalee, Rebecca Towle, James Lawson, Christopher Dickman, Cathie Garnis

Published Feb 4, 2020 · Vol. 11, No. 5 · pp. 523-534

Keywords: oral squamous cell carcinoma, DNA methylation, SMPD3, erlotinib, cancer progression

Cetuximab is efficient and safe in patients with advanced cutaneous squamous cell carcinoma: a retrospective, multicentre study Research Paper

Henri Montaudié, Julien Viotti, Patrick Combemale, Caroline Dutriaux, Nicolas Dupin, Caroline Robert, Laurent Mortier, Régis Kaphan, Anne-Bénédicte Duval-Modeste, Stéphane Dalle, Julie De Quatrebarbes, Andrea Stefan, Florence Brunet-Possenti, Maria Kogay, Alexandra Picard-Gauci, Gilles Poissonnet, Frédéric Peyrade

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 378-385

Keywords: cutaneous squamous cell carcinoma, cetuximab, epidermal growth factor receptor

Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin Research Paper

Gleb Baida, Shivani Agarwal, Ben Readhead, Joel T. Dudley, Irina Budunova

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 409-418

Keywords: glucocorticoid, skin atrophy, REDD1, mTOR, sexual dimorphism

Circulating tumor DNA analysis in the era of precision oncology Review

Rabih Said, Nicolas Guibert, Geoffrey R. Oxnard, Apostolia M. Tsimberidou

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 188-211

Keywords: circulating tumor DNA analysis, clinical trials, targeted therapy, genomic profiling

Novel functional anti-HER3 monoclonal antibodies with potent anti-cancer effects on various human epithelial cancers Research Paper

Kouki Okita, Shogo Okazaki, Shinya Uejima, Erina Yamada, Hiroki Kaminaka, Misa Kondo, Shiho Ueda, Ryo Tokiwa, Nami Iwata, Akitaka Yamasaki, Natsumi Hayashi, Dai Ogura, Kenji Hirotani, Toshiaki Yoshioka, Masahiro Inoue, Kazue Masuko, Takashi Masuko

Published Jan 7, 2020 · Vol. 11, No. 1 · pp. 31-45

Keywords: CDR, HER3, internalization, mAb, NRG1

The synergistic inhibitory effect of combining therapies targeting EGFR and mitochondria in sarcomas Research Paper

Xiaochun Wang, Reichelle X. Yeo, Philip J. Hogg, David Goldstein, Philip Crowe, Pierre J. Dilda, Jia-Lin Yang

Published Jan 7, 2020 · Vol. 11, No. 1 · pp. 46-61

Keywords: EGFR-targeted therapy, mitochondria inhibitor, tumour metabolism inhibition, sarcomas, combination therapy

EGFR806-CAR T cells selectively target a tumor-restricted EGFR epitope in glioblastoma Research Paper

Ali C. Ravanpay, Juliane Gust, Adam J. Johnson, Lisa S. Rolczynski, Michelle Cecchini, Cindy A. Chang, Virginia J. Hoglund, Rithun Mukherjee, Nicholas A. Vitanza, Rimas J. Orentas, Michael C. Jensen

Published Dec 17, 2019 · Vol. 10, No. 66 · pp. 7080-7095

Keywords: glioblastoma, CAR T cell, EGFR, immunotherapy, mAb806

NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis Research Paper

Vasiliki Salameti, Priyanka G. Bhosale, Ashley Ames-Draycott, Kalle Sipilä, Fiona M. Watt

Published Nov 26, 2019 · Vol. 10, No. 63 · pp. 6791-6804

Keywords: oral squamous cell carcinoma (OSCC), NOTCH1, SERPINE1, ETV7/TEL2, cell adhesion

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper

Thierry M. Nordmann, Olivia Messerli-Odermatt, Larissa Meier, Sara Micaletto, Thomas Coppetti, Mirjam Nägeli, Jivko Kamarachev, Ken Kudura, Sandra N. Freiberger, Tamara Rordorf, Joanna Mangana, Ralph Braun, Reinhard Dummer

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6647-6650

Keywords: ERBB2 protein, Paget disease, extramammary, trastuzumab, lapatinib

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

Rowland H. Han, Gavin P. Dunn, Milan G. Chheda, Albert H. Kim

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6739-6753

Keywords: brain metastases, targeted therapy, precision medicine, immunotherapy, systemic therapy

The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44 Research Paper

Chunmei Zhao, Benjamin J. Thompson, Kelly Chen, Feng Gao, Barbara Blouw, Mathieu Marella, Susan Zimmerman, Trevor Kimbler, Sheryl Garrovillo, Jesse Bahn, Lei Huang, Zhongdong Huang, H. Michael Shepard, Sanna Rosengren, Christopher D. Thanos, Daniel C. Maneval

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6561-6576

Keywords: hyaluronan, breast cancer, xenograft, tumor microenvironment, CD44

Randomized phase 3 open label study of quality of life of patients on Pemetrexed versus Erlotinib as maintenance therapy for advanced non squamous non EGFR mutated non small cell lung cancer Research Paper

Vijay Patil, Amit Joshi, Vanita Noronha, Vivek Agarwala, Anuradha Chougule, Sadhana Kanan, Atanu Bhattacharjee, Arun Chandrasekharan, Nikhil Pande, Vijai Simha, Supriya Goud, Sucheta More, Rajiv Kumar, Abhishek Mahajan, Amit Janu, Nilendu Purandare, Kumar Prabhash

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6297-6307

Keywords: maintenance, pemetrexed, erlotinib, NSCLC

Clinical significance of evaluating hormone receptor and HER2 protein using cell block against metastatic breast cancer: a multi-institutional study Research Paper

Akira Matsui, Yuya Murata, Norikazu Masuda, Kiyoshi Mori, Masato Takahashi, Katsushige Yamashiro, Kenjirou Aogi, Shigeto Maeda, Masahiro Itou, Shinji Ozaki, Kazuya Kuraoka, Yasuyuki Satou, Shu Ichihara, Eriko Tokunaga, Kenichi Taguchi, Takanori Watanabe, Hiroyoshi Suzuki, Aiko Nagayama, Rieko Nishimura

Published Oct 1, 2019 · Vol. 10, No. 55 · pp. 5680-5689

Keywords: metastatic breast cancer, receptor discordance, cell block, cytological specimen, prognosis

DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model Research Paper

Takeshi Jimbo, Mana Hatanaka, Takahiro Komatsu, Tomoe Taira, Kentaro Kumazawa, Naoyuki Maeda, Takashi Suzuki, Masahiro Ota, Noriyasu Haginoya, Takeshi Isoyama, Kosaku Fujiwara

Published Aug 27, 2019 · Vol. 10, No. 50 · pp. 5152-5167

Keywords: AXL, DS-1205, EGFR-TKI resistance, erlotinib, osimertinib

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Efficacy of osimertinib against EGFRvIII+ glioblastoma Research Paper

A 3D biofabricated cutaneous squamous cell carcinoma tissue model with multi-channel confocal microscopy imaging biomarkers to quantify antitumor effects of chemotherapeutics in tissue Research Paper

Gene expression dynamic analysis reveals co-activation of Sonic Hedgehog and epidermal growth factor followed by dynamic silencing Research Paper

Pirfenidone anti-fibrotic effects are partially mediated by the inhibition of MUC1 bioactivation Research Paper

Early prediction of resistance to tyrosine kinase inhibitors by plasma monitoring of EGFR mutations in NSCLC: a new algorithm for patient selection and personalized treatment Research Paper

Risk factors for breast cancer brain metastases: a systematic review Review

Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response Research Paper

Cetuximab is efficient and safe in patients with advanced cutaneous squamous cell carcinoma: a retrospective, multicentre study Research Paper

Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin Research Paper

Circulating tumor DNA analysis in the era of precision oncology Review

Novel functional anti-HER3 monoclonal antibodies with potent anti-cancer effects on various human epithelial cancers Research Paper

The synergistic inhibitory effect of combining therapies targeting EGFR and mitochondria in sarcomas Research Paper

EGFR806-CAR T cells selectively target a tumor-restricted EGFR epitope in glioblastoma Research Paper

NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis Research Paper

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44 Research Paper

Randomized phase 3 open label study of quality of life of patients on Pemetrexed versus Erlotinib as maintenance therapy for advanced non squamous non EGFR mutated non small cell lung cancer Research Paper

Clinical significance of evaluating hormone receptor and HER2 protein using cell block against metastatic breast cancer: a multi-institutional study Research Paper

DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Efficacy of osimertinib against EGFRvIII+ glioblastoma Research Paper

A 3D biofabricated cutaneous squamous cell carcinoma tissue model with multi-channel confocal microscopy imaging biomarkers to quantify antitumor effects of chemotherapeutics in tissue Research Paper

Gene expression dynamic analysis reveals co-activation of Sonic Hedgehog and epidermal growth factor followed by dynamic silencing Research Paper

Pirfenidone anti-fibrotic effects are partially mediated by the inhibition of MUC1 bioactivation Research Paper

Early prediction of resistance to tyrosine kinase inhibitors by plasma monitoring of EGFR mutations in NSCLC: a new algorithm for patient selection and personalized treatment Research Paper

Risk factors for breast cancer brain metastases: a systematic review Review

Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response Research Paper

Cetuximab is efficient and safe in patients with advanced cutaneous squamous cell carcinoma: a retrospective, multicentre study Research Paper

Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin Research Paper

Circulating tumor DNA analysis in the era of precision oncology Review

Novel functional anti-HER3 monoclonal antibodies with potent anti-cancer effects on various human epithelial cancers Research Paper

The synergistic inhibitory effect of combining therapies targeting EGFR and mitochondria in sarcomas Research Paper

EGFR806-CAR T cells selectively target a tumor-restricted EGFR epitope in glioblastoma Research Paper

NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis Research Paper

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2S310F mutated extramammary Paget’s disease Research Paper

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44 Research Paper

Randomized phase 3 open label study of quality of life of patients on Pemetrexed versus Erlotinib as maintenance therapy for advanced non squamous non EGFR mutated non small cell lung cancer Research Paper

Clinical significance of evaluating hormone receptor and HER2 protein using cell block against metastatic breast cancer: a multi-institutional study Research Paper

DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model Research Paper

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper