The Oncosearch | Oncotarget

Starving cancer cells to enhance DNA damage and immunotherapy response Research Perspective

Aashirwad Shahi, Dawit Kidane

Published Jun 12, 2024 · Vol. 15, No. 1 · pp. 392-399

Keywords: amino acid depletion, DNA damage, DNA repair, Immunotherapy, tumor immunity

Bruton’s tyrosine kinase inhibitor-related cardiotoxicity: The quest for predictive biomarkers and improved risk stratification Research Perspective

Jai N. Patel, Jai Singh, Nilanjan Ghosh

Published May 25, 2024 · Vol. 15, No. 1 · pp. 355-359

Keywords: BTK inhibitor, cardiotoxicity, biomarkers, risk, genetics

Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

Benigno C. Valdez, Apostolia M. Tsimberidou, Bin Yuan, Yago Nieto, Mehmet A. Baysal, Abhijit Chakraborty, Clark R. Andersen, Borje S. Andersson

Published May 25, 2024 · Vol. 15, No. 1 · pp. 361-373

Keywords: decitabine, HDAC inhibitors, pancreatic cancer, PARP inhibitors, synergistic cytotoxicity

The importance of integrated therapies on cancer: Silibinin, an old and new molecule Review

Elisa Roca, Giuseppe Colloca, Fiorella Lombardo, Andrea Bellieni, Alessandra Cucinella, Giorgio Madonia, Licia Martinelli, Maria Elisa Damiani, Ilaria Zampieri, Antonio Santo

Published May 14, 2024 · Vol. 15, No. 1 · pp. 345-353

Keywords: silibinin, anti-inflammatory, inflammation, toxicity, integrated therapy

GZ17-6.02 kills PDX isolates of uveal melanoma Research Paper

Laurence Booth, Jane L. Roberts, Ivan Spasojevic, Kaitlyn C. Baker, Andrew Poklepovic, Cameron West, John M. Kirkwood, Paul Dent

Published May 9, 2024 · Vol. 15, No. 1 · pp. 328-344

Keywords: autophagy, ER stress, GZ17-6.02, doxorubicin, afatinib, neratinib

The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response Research Paper

Lulzim Shkreta, Johanne Toutant, Aurélie Delannoy, David Durantel, Anna Salvetti, Sophie Ehresmann, Martin Sauvageau, Julien A. Delbrouck, Alice Gravel-Trudeau, Christian Comeau, Caroline Huard, Jasmin Coulombe-Huntington, Mike Tyers, David Grierson, Pierre-Luc Boudreault, Benoit Chabot

Published May 9, 2024 · Vol. 15, No. 1 · pp. 313-325

Keywords: CLK kinases inhibitors, EMT, antiviral immune response, microtubules, metastasis

Cyclin D1 expression in penile cancer Research Paper

Wesliany Everton Duarte, Jaqueline Diniz Pinho, Syomara Pereira da Costa Melo, Denner Rodrigo Diniz Duarte, Juliana Martins da Guia Ribeiro do Carmo, André Salim Khayat, José Ribamar Rodrigues Calixto, Marcos Adriano Garcia Campos, Rita da Graça Carvalhal Frazão Correa, Antonio Machado Alencar Júnior, Antônio Augusto Lima Teixeira-Júnior, Gyl Eanes Barros Silva

Published May 3, 2024 · Vol. 15, No. 1 · pp. 302-311

Keywords: immunohistochemistry, biomarkers, cyclin D1, penile neoplasms

Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN Research Paper

Kevin C. Ma, Esther Mena, Liza Lindenberg, Nathan S. Lay, Phillip Eclarinal, Deborah E. Citrin, Peter A. Pinto, Bradford J. Wood, William L. Dahut, James L. Gulley, Ravi A. Madan, Peter L. Choyke, Ismail Baris Turkbey, Stephanie A. Harmon

Published May 2, 2024 · Vol. 15, No. 1 · pp. 288-300

Keywords: deep learning, PSMA PET, attenuation correction

Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure Research Paper

Shengliang Zhang, Wafik S. El-Deiry

Published Apr 29, 2024 · Vol. 15, No. 1 · pp. 275-284

Keywords: SARS-COV2 spike, p53, MDM2, chemotherapy, cancer

Exploring the role of GHRH antagonist MIA-602 in overcoming Doxorubicin-resistance in acute myeloid leukemia Research Paper

Simonetta I. Gaumond, Rama Abdin, Joel Costoya, Andrew V. Schally, Joaquin J. Jimenez

Published Mar 30, 2024 · Vol. 15, No. 1 · pp. 248-254

Keywords: leukemia, AML, resistance, growth hormone-releasing hormone, MIA-602

Retraction: Knockdown of TRIM65 inhibits lung cancer cell proliferation, migration and invasion: A therapeutic target in human lung cancer Retraction

Xiao-Lin Wang, Wei-Ping Shi, Hong-Can Shi, Shi-Chun Lu, Kang Wang, Chao Sun, Jian-Sheng He, Wei-Guo Jin, Xiao-Xia Lv, Hui Zou, Yu-Sheng Shu

Published Mar 22, 2024 · Vol. 15, No. 1 · pp. 312-312

From osimertinib to preemptive combinations Research Perspective

Mikhail V. Blagosklonny

Published Mar 14, 2024 · Vol. 15, No. 1 · pp. 232-237

Keywords: lung cancer, NSCLC, EGFR, resistance, afatinib, gefitinib, capmatinib

Durvalumab and tremelimumab before surgery in patients with hormone receptor positive, HER2-negative stage II–III breast cancer Research Paper

Haven R. Garber, Sreyashi Basu, Sonali Jindal, Zhong He, Khoi Chu, Akshara Singareeka Raghavendra, Clinton Yam, Lumarie Santiago, Beatriz E. Adrada, Padmanee Sharma, Elizabeth A. Mittendorf, Jennifer K. Litton

Published Mar 2, 2024 · Vol. 15, No. 1 · pp. 238-247

Keywords: breast cancer, ER positive, immunotherapy, neoadjuvant chemotherapy, tumor microenvironment

Assessment of serum tumor markers CEA, CA-125, and CA19-9 as adjuncts in non-small cell lung cancer management Research Paper

Scott Strum, Mark Vincent, Meghan Gipson, Eric McArthur, Daniel Breadner

Published Feb 28, 2024 · Vol. 15, No. 1 · pp. 381-388

Keywords: tumor marker, biomarker, lung cancer, NSCLC, translational research

Analytical validation of NeXT Personal^®, an ultra-sensitive personalized circulating tumor DNA assay Research Paper

Josette Northcott, Gabor Bartha, Jason Harris, Conan Li, Fabio C.P. Navarro, Rachel Marty Pyke, Manqing Hong, Qi Zhang, Shuyuan Ma, Tina X. Chen, Janet Lai, Nitin Udar, Juan-Sebastian Saldivar, Erin Ayash, Joshua Anderson, Jiang Li, Tiange Cui, Tu Le, Ruthie Chow, Randy Jerel Velasco, Chris Mallo, Rose Santiago, Robert C. Bruce, Laurie J. Goodman, Yi Chen, Dan Norton, Richard O. Chen, John M. Lyle

Published Feb 21, 2024 · Vol. 15, No. 1 · pp. 200-218

Keywords: circulating tumor DNA, whole genome sequencing, molecular residual disease, tumor-informed assay, analytical validation

ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells Research Paper

Benigno C. Valdez, Bin Yuan, David Murray, Jeremy L. Ramdial, Uday Popat, Yago Nieto, Borje S. Andersson

Published Feb 21, 2024 · Vol. 15, No. 1 · pp. 220-231

Keywords: acute myeloid leukemia, pre-transplant regimens, venetoclax, thiotepa, busulfan

Prevalence and spectrum of germline BRCA1 and BRCA2 in a cohort of ovarian cancer patients from the Salento peninsula (Southern Italy): a matter of preventive health Research Paper

Elisabetta De Matteis, Maria Rosaria Tumolo, Paolo Tarantino, Mariangela Ciccarese, Tiziana Grassi, Francesco Bagordo, Maria Rita De Giorgio, Emanuele Rizzo, Graziana Ronzino

Published Feb 15, 2024 · Vol. 15, No. 1 · pp. 134-141

Keywords: ovarian cancer, BRCA1, BRCA2, mutation

Retraction: Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy Retraction

Changhwan Yoon, Kevin K. Chang, Jun Ho Lee, William D. Tap, Charles P. Hart, M. Celeste Simon, Sam S. Yoon

Published Feb 8, 2024 · Vol. 15, No. 1 · pp. 123-123

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

Thomas M. Cardillo, Maria B. Zalath, Roberto Arrojo, Robert M. Sharkey, Serengulam V. Govindan, Chien-Hsing Chang, David M. Goldenberg

Published Jan 30, 2024 · Vol. 15, No. 1 · pp. 144-158

Keywords: sacituzumab govitecan, Trop-2, SN-38, carboplatin, cisplatin

Neurotrophic-tyrosine receptor kinase gene fusion in papillary thyroid cancer: A clinicogenomic biobank and record linkage study from Finland Research Paper

Wei Zhang, Arndt A. Schmitz, Roosa E. Kallionpää, Merja Perälä, Niina Pitkänen, Mikko Tukiainen, Erika Alanne, Korinna Jöhrens, Renate Schulze-Rath, Bahman Farahmand, Jihong Zong

Published Jan 12, 2024 · Vol. 15, No. 1 · pp. 106-116

Keywords: NTRK gene fusion, papillary thyroid cancer, clinicogenomic, epidemiology, biobank

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Starving cancer cells to enhance DNA damage and immunotherapy response Research Perspective

Bruton’s tyrosine kinase inhibitor-related cardiotoxicity: The quest for predictive biomarkers and improved risk stratification Research Perspective

Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

The importance of integrated therapies on cancer: Silibinin, an old and new molecule Review

GZ17-6.02 kills PDX isolates of uveal melanoma Research Paper

The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response Research Paper

Cyclin D1 expression in penile cancer Research Paper

Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN Research Paper

Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure Research Paper

Exploring the role of GHRH antagonist MIA-602 in overcoming Doxorubicin-resistance in acute myeloid leukemia Research Paper

Retraction: Knockdown of TRIM65 inhibits lung cancer cell proliferation, migration and invasion: A therapeutic target in human lung cancer Retraction

From osimertinib to preemptive combinations Research Perspective

Durvalumab and tremelimumab before surgery in patients with hormone receptor positive, HER2-negative stage II–III breast cancer Research Paper

Assessment of serum tumor markers CEA, CA-125, and CA19-9 as adjuncts in non-small cell lung cancer management Research Paper

Analytical validation of NeXT Personal^®, an ultra-sensitive personalized circulating tumor DNA assay Research Paper

ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells Research Paper

Prevalence and spectrum of germline BRCA1 and BRCA2 in a cohort of ovarian cancer patients from the Salento peninsula (Southern Italy): a matter of preventive health Research Paper

Retraction: Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy Retraction

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

Neurotrophic-tyrosine receptor kinase gene fusion in papillary thyroid cancer: A clinicogenomic biobank and record linkage study from Finland Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Starving cancer cells to enhance DNA damage and immunotherapy response Research Perspective

Bruton’s tyrosine kinase inhibitor-related cardiotoxicity: The quest for predictive biomarkers and improved risk stratification Research Perspective

Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

The importance of integrated therapies on cancer: Silibinin, an old and new molecule Review

GZ17-6.02 kills PDX isolates of uveal melanoma Research Paper

The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response Research Paper

Cyclin D1 expression in penile cancer Research Paper

Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN Research Paper

Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure Research Paper

Exploring the role of GHRH antagonist MIA-602 in overcoming Doxorubicin-resistance in acute myeloid leukemia Research Paper

Retraction: Knockdown of TRIM65 inhibits lung cancer cell proliferation, migration and invasion: A therapeutic target in human lung cancer Retraction

From osimertinib to preemptive combinations Research Perspective

Durvalumab and tremelimumab before surgery in patients with hormone receptor positive, HER2-negative stage II–III breast cancer Research Paper

Assessment of serum tumor markers CEA, CA-125, and CA19-9 as adjuncts in non-small cell lung cancer management Research Paper

Analytical validation of NeXT Personal®, an ultra-sensitive personalized circulating tumor DNA assay Research Paper

ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells Research Paper

Prevalence and spectrum of germline BRCA1 and BRCA2 in a cohort of ovarian cancer patients from the Salento peninsula (Southern Italy): a matter of preventive health Research Paper

Retraction: Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy Retraction

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

Neurotrophic-tyrosine receptor kinase gene fusion in papillary thyroid cancer: A clinicogenomic biobank and record linkage study from Finland Research Paper

Analytical validation of NeXT Personal^®, an ultra-sensitive personalized circulating tumor DNA assay Research Paper