The Oncosearch | Oncotarget

Tumor suppressor genes and allele-specific expression: mechanisms and significance Research Paper

Evan A. Clayton, Shareef Khalid, Dongjo Ban, Lu Wang, I. King Jordan, John F. McDonald

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 462-479

Keywords: allele-specific expression, alternative splicing, antisense RNA, cancer, tumor-suppressor genes

Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery Research Paper

Ling F. Ye, Eduard Reznik, Joshua M. Korn, Fallon Lin, Guizhi Yang, Kimberly Malesky, Hui Gao, Alice Loo, Raymond Pagliarini, Tom Mikkelsen, Donald C. Lo, Ana C. deCarvalho, Brent R. Stockwell

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 443-451

Keywords: cell death, chemical biology, glioma, cancer

Systemic oncolytic adenovirus delivered in mesenchymal carrier cells modulate tumor infiltrating immune cells and tumor microenvironment in mice with neuroblastoma Research Paper

Lidia Franco-Luzón, África González-Murillo, Cristina Alcántara-Sánchez, Lorena García-García, Maryam Tabasi, Ana Luis Huertas, Louis Chesler, Manuel Ramírez

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 347-361

Keywords: oncolytic virotherapy, neuroblastoma, mesenchymal stem cells, tumor microenvironment, immune response

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas Research Paper

Chie Nakashima, Kazuhiko Yamamoto, Shingo Kishi, Takamitsu Sasaki, Hitoshi Ohmori, Rina Fujiwara-Tani, Shiori Mori, Isao Kawahara, Yukiko Nishiguchi, Takuya Mori, Masuo Kondoh, Yi Luo, Tadaaki Kirita, Hiroki Kuniyasu

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 309-321

Keywords: clostridium perfringens enterotoxin, claudin-4, YAP, Hippo signal, oral squamous cell carcinoma, Pathology

Correction: Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: Involvement of p53/FoxO3A axis Correction

Saroj Nepal, Mi Jin Kim, Jin Tae Hong, Sang Hyun Kim, Dong-Hwan Sohn, Sung Hee Lee, Kyung Song, Dong Young Choi, Eung Seok Lee, Pil-Hoon Park

Published Jan 22, 2020 · Vol. 11, No. 30 · pp. 2956-2957

Correction: Oroxylin A modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53 Correction

Chen Qiao, Na Lu, Yuxin Zhou, Ting Ni, Yuanyuan Dai, Zhiyu Li, Qinglong Guo, Libin Wei

Published Jan 22, 2020

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. McNulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 216-236

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

Response of a chemo-resistant triple-negative breast cancer patient to a combination of p62-encoding plasmid, Elenagen, and CMF chemotherapy Case Report

Dmitry M. Ponomarenko, Vladimir L. Gabai, Albert A. Sufianov, Sergey I. Kolesnikov, Alexander M. Shneider

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 294-299

Keywords: cancer immunotherapy, cancer chemotherapy, p62 plasmid, cancer vaccine

The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis Research Paper

Ryan M. Carey, Karthik Rajasekaran, Tyler Seckar, Xiang Lin, Zhi Wei, Charles C.L. Tong, Viran J. Ranasinghe, Jason G. Newman, Bert W. O'Malley Jr., Gregory S. Weinstein, Michael D. Feldman, Erle S. Robertson

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 282-293

Keywords: HPV, cancer, virus, virome, oropharyngeal squamous cell carcinoma

Prevalence and clinical significance of VHL mutations and 3p25 deletions in renal tumor subtypes Research Paper

Franziska Büscheck, Christoph Fraune, Ronald Simon, Martina Kluth, Claudia Hube-Magg, Christina Möller-Koop, Imren Sarper, Kathrin Ketterer, Tjark Henke, Christian Eichelberg, Roland Dahlem, Waldemar Wilczak, Guido Sauter, Margit Fisch, Till Eichenauer, Michael Rink

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 237-249

Keywords: renal cell tumors, von Hippel-Lindau gene, VHL mutation, 3p copy number, fluorescence in-situ hybridization

TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC Research Paper

Julia Roeper, Markus Falk, Athena Chalaris-Rißmann, Anne C. Lueers, Hayat Ramdani, Katrin Wedeken, Ursula Stropiep, Linda Diehl, Markus Tiemann, Lukas C. Heukamp, Fabian Otto-Sobotka, Frank Griesinger

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 250-264

Keywords: NSCLC, EGFR, TP53 mutation, TKI

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Hengyu Lu, Chen Liu, Hung Huynh, Thi Bich Uyen Le, Matthew J. LaMarche, Morvarid Mohseni, Jeffrey A. Engelman, Peter S. Hammerman, Giordano Caponigro, Huai-Xiang Hao

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 265-281

Keywords: SHP2, FGFR, resistance, feedback activation

Stratifying the stratifiers of triple negative breast cancer Editorial

Dong-Yu Wang, Zhe Jiang, Eldad Zacksenhaus

Published Jan 18, 2020 · Vol. 11, No. 4 · pp. 306-308

Keywords: triple negative breast cancer, molecular stratification, prognostication, microRNA, immunomodulation

Carcinogenetic initiation contributed by EpCAM+ cancer cells in orthotopic HCC models of immunocompetent and athymic mice Research Paper

Harshul Pandit, Yan Li, Qianqian Zheng, Wei Guo, Youxi Yu, Suping Li, Robert C.G. Martin

Published Jan 17, 2020 · Vol. 11, No. 22 · pp. 2047-2060

Keywords: hepatocellular carcinoma, Wnt/β-catenin signaling, cancer stem cells, epithelial cell adhesion molecule (EpCAM), tumor-initiating cells

Correction: Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation Correction

Ying Yan, Ashley L. Hein, Asserewou Etekpo, Katrina M. Burchett, Chi Lin, Charles A. Enke, Surinder K. Batra, Kenneth H. Cowan, Michel M. Ouellette

Published Jan 16, 2020 · Vol. 11, No. 3 · pp. 304-304

Deregulation of cancer-stem-cell-associated miRNAs in tissues and sera of colorectal cancer patients Research Paper

Cristiano Farace, Andrea Pisano, Carmen Griñan-Lison, Giuliana Solinas, Gema Jiménez, Marina Serra, Esmeralda Carrillo, Fabrizio Scognamillo, Federico Attene, Andrea Montella, Juan Antonio Marchal, Roberto Madeddu

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 116-130

Keywords: colorectal cancer, metastasis, cancer stem cell, microRNA, biomarker

KHSRP-bound small nucleolar RNAs associate with promotion of cell invasiveness and metastasis of pancreatic cancer Research Paper

Keisuke Taniuchi, Mitsunari Ogasawara

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 131-147

Keywords: RNA-binding protein, small nucleolar RNA, pancreatic cancer, cell invasion, metastasis

Sequence conservation of mitochondrial (mt)DNA during expansion of clonal mammary epithelial populations suggests a common mtDNA template in CzechII mice Research Paper

Jabril R. Johnson, Justin B. Lack, Corinne A. Boulanger, Lauren E. Ragle, Gilbert H. Smith

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 161-174

Keywords: mitochondrial DNA, next-generation sequencing, clonal expansion, mammary cancer

Circulating tumor DNA analysis in the era of precision oncology Review

Rabih Said, Nicolas Guibert, Geoffrey R. Oxnard, Apostolia M. Tsimberidou

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 188-211

Keywords: circulating tumor DNA analysis, clinical trials, targeted therapy, genomic profiling

The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development of metastasis in uveal melanoma Research Paper

Klara Fodor, Nikoletta Dobos, Andrew Schally, Zita Steiber, Gabor Olah, Eva Sipos, Lorant Szekvolgyi, Gabor Halmos

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 175-187

Keywords: uveal melanoma, luteinizing hormone-releasing hormone (LHRH) receptor, angiogenesis, MASPIN/SERPINB5, AEZS-108 (AN-152/Zoptarelin Doxorubicin Acetate)

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Tumor suppressor genes and allele-specific expression: mechanisms and significance Research Paper

Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery Research Paper

Systemic oncolytic adenovirus delivered in mesenchymal carrier cells modulate tumor infiltrating immune cells and tumor microenvironment in mice with neuroblastoma Research Paper

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas Research Paper

Correction: Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: Involvement of p53/FoxO3A axis Correction

Correction: Oroxylin A modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53 Correction

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Response of a chemo-resistant triple-negative breast cancer patient to a combination of p62-encoding plasmid, Elenagen, and CMF chemotherapy Case Report

The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis Research Paper

Prevalence and clinical significance of VHL mutations and 3p25 deletions in renal tumor subtypes Research Paper

TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC Research Paper

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Stratifying the stratifiers of triple negative breast cancer Editorial

Carcinogenetic initiation contributed by EpCAM+ cancer cells in orthotopic HCC models of immunocompetent and athymic mice Research Paper

Correction: Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation Correction

Deregulation of cancer-stem-cell-associated miRNAs in tissues and sera of colorectal cancer patients Research Paper

KHSRP-bound small nucleolar RNAs associate with promotion of cell invasiveness and metastasis of pancreatic cancer Research Paper

Sequence conservation of mitochondrial (mt)DNA during expansion of clonal mammary epithelial populations suggests a common mtDNA template in CzechII mice Research Paper

Circulating tumor DNA analysis in the era of precision oncology Review

The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development of metastasis in uveal melanoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Tumor suppressor genes and allele-specific expression: mechanisms and significance Research Paper

Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery Research Paper

Systemic oncolytic adenovirus delivered in mesenchymal carrier cells modulate tumor infiltrating immune cells and tumor microenvironment in mice with neuroblastoma Research Paper

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas Research Paper

Correction: Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: Involvement of p53/FoxO3A axis Correction

Correction: Oroxylin A modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53 Correction

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Response of a chemo-resistant triple-negative breast cancer patient to a combination of p62-encoding plasmid, Elenagen, and CMF chemotherapy Case Report

The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis Research Paper

Prevalence and clinical significance of VHL mutations and 3p25 deletions in renal tumor subtypes Research Paper

TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC Research Paper

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Stratifying the stratifiers of triple negative breast cancer Editorial

Carcinogenetic initiation contributed by EpCAM+ cancer cells in orthotopic HCC models of immunocompetent and athymic mice Research Paper

Correction: Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation Correction

Deregulation of cancer-stem-cell-associated miRNAs in tissues and sera of colorectal cancer patients Research Paper

KHSRP-bound small nucleolar RNAs associate with promotion of cell invasiveness and metastasis of pancreatic cancer Research Paper

Sequence conservation of mitochondrial (mt)DNA during expansion of clonal mammary epithelial populations suggests a common mtDNA template in CzechII mice Research Paper

Circulating tumor DNA analysis in the era of precision oncology Review

The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development of metastasis in uveal melanoma Research Paper