The Oncosearch | Oncotarget

Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells Research Paper

Elaine A. Dunlop, Charlotte E. Johnson, Marie Wiltshire, Rachel J. Errington, Andrew R. Tee

Published Mar 15, 2017 · Vol. 8, No. 30 · pp. 48711-48724

PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide Research Paper

Laurence Booth, Jane L. Roberts, Andrew Poklepovic, Sarah Gordon, Paul Dent

Published Nov 26, 2016 · Vol. 8, No. 1 · pp. 1449-1468

Curcumin targets the TFEB-lysosome pathway for induction of autophagy Research Paper

Jianbin Zhang, Jigang Wang, Jian Xu, Yuanqiang Lu, Jiukun Jiang, Liming Wang, Han-Ming Shen, Dajing Xia

Published Sep 28, 2016 · Vol. 7, No. 46 · pp. 75659-75671

Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation Research Paper

Suraj Peri, Elena Caretti, Rossella Tricarico, Karthik Devarajan, Mitchell Cheung, Eleonora Sementino, Craig W. Menges, Emmanuelle Nicolas, Lisa A. Vanderveer, Sharon Howard, Peggy Conrad, James A. Crowell, Kerry S. Campbell, Eric A. Ross, Andrew K. Godwin, Anthony T. Yeung, Margie L. Clapper, Robert G. Uzzo, Elizabeth P. Henske, Christopher J. Ricketts, Cathy D. Vocke, W. Marston Linehan, Joseph R. Testa, Alfonso Bellacosa, Levy Kopelovich, Alfred G. Knudson

Published Sep 22, 2016 · Vol. 8, No. 11 · pp. 17628-17642

Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancer Research Paper

Nooshin Mirkheshti, Sulgi Park, Shoulei Jiang, Jodie Cropper, Sherry L. Werner, Chung S. Song, Bandana Chatterjee

Published Aug 19, 2016 · Vol. 7, No. 38 · pp. 62240-62254

Oncogenic effects of urotensin-II in cells lacking tuberous sclerosis complex-2 Research Paper

Alexander A. Goldberg, Kwang-Bo Joung, Asma Mansuri, Yujin Kang, Raquel Echavarria, Ljiljana Nikolajev, Yang Sun, Jane J. Yu, Stephane A. Laporte, Adel Schwertani, Arnold S. Kristof

Published Jul 21, 2016 · Vol. 7, No. 38 · pp. 61152-61165

VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation Research Paper

Nishant Mohan, Yi Shen, Milos Dokmanovic, Yukinori Endo, Dianne S. Hirsch, Wen Jin Wu

Published Jul 7, 2016 · Vol. 7, No. 32 · pp. 52239-52254

mTORC1-mediated downregulation of COX2 restrains tumor growth caused by TSC2 deficiency Research Paper

Hongwu Li, Fuquan Jin, Keguo Jiang, Shuang Ji, Li Wang, Zhaofei Ni, Xianguo Chen, Zhongdong Hu, Hongbing Zhang, Yehai Liu, Yide Qin, Xiaojun Zha

Published Apr 7, 2016 · Vol. 7, No. 19 · pp. 28435-28447

PI3K/Akt promotes feedforward mTORC2 activation through IKKÎ± Priority Research Paper

Han C. Dan, Ricardo J. Antonia, Albert S. Baldwin

Published Mar 25, 2016 · Vol. 7, No. 16 · pp. 21064-21075

Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus Research Paper

Sun Min Lim, Hyung Soon Park, Sangwoo Kim, Sora Kim, Siraj M. Ali, Joel R. Greenbowe, In Seok Yang, Nak-Jung Kwon, Jae Lyun Lee, Min-Hee Ryu, Jin-Hee Ahn, Jeeyun Lee, Min Goo Lee, Hyo Song Kim, Hyunki Kim, Hye Ryun Kim, Yong Wha Moon, Hyun Cheol Chung, Joo-Hang Kim, Yoon-Koo Kang, Byoung Chul Cho

Published Feb 7, 2016 · Vol. 7, No. 9 · pp. 10547-10556

Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells Research Paper

Hongyu Li, Jing Hu, Shuhong Wu, Li Wang, Xiaobo Cao, Xiaoshan Zhang, Bingbing Dai, Mengru Cao, Ruping Shao, Ran Zhang, Mourad Majidi, Lin Ji, John V. Heymach, Michael Wang, Shiyang Pan, John Minna, Reza J. Mehran, Stephen G. Swisher, Jack A. Roth, Bingliang Fang

Published Dec 9, 2015 · Vol. 7, No. 3 · pp. 3548-3558

Point mutations of the mTOR-RHEB pathway in renal cell carcinoma Priority Research Paper

Arindam P. Ghosh, Christopher B. Marshall, Tatjana Coric, Eun-hee Shim, Richard Kirkman, Mary E. Ballestas, Mitsuhiko Ikura, Mary-Ann Bjornsti, Sunil Sudarshan

Published Jul 22, 2015 · Vol. 6, No. 20 · pp. 17895-17910

AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf & TSC1/TSC2 Research Paper

Hui-Ping Lin, Ching-Yu Lin, Chieh Huo, Yee-Jee Jan, Jen-Chih Tseng, Shih Sheng Jiang, Ying-Yu Kuo, Shyh-Chang Chen, Chih-Ting Wang, Tzu-Min Chan, Jun-Yang Liou, John Wang, Wun-Shaing Wayne Chang, Chung-Ho Chang, Hsing-Jien Kung, Chih-Pin Chuu

Published Jul 10, 2015 · Vol. 6, No. 29 · pp. 27097-27112

A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation Research Paper

Jennifer Munkley, Prabhakar Rajan, Nicholas P. Lafferty, Caroline Dalgliesh, Robert M. Jackson, Craig N. Robson, Hing Y. Leung, David J. Elliott

Published Oct 21, 2013 · Vol. 5, No. 1 · pp. 131-139

Keywords: TSC2, mTOR, mRNA isoform, androgen, prostate cancer

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

James Andrew McCubrey, Linda Steeman, William Chappell, Stephen Abrams, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Paolo Fagone, Grazia Malaponte, Maria Mazzarino, Saverio Candido, Massimo Libra, Jorg Basecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini, Alberto Martelli

Published Sep 20, 2012 · Vol. 3, No. 9 · pp. 954-987

Keywords: targeted therapy, therapy resistance, mutations, Raf, Akt, PI3K, mTOR

Targeting Rb mutant cancers by inactivating TSC2 Research Perspective

Jennifer S. Searle, Binghui Li, Wei Du

Published Jul 26, 2010 · Vol. 1, No. 3 · pp. 228-232

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Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells Research Paper

PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide Research Paper

Curcumin targets the TFEB-lysosome pathway for induction of autophagy Research Paper

Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation Research Paper

Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancer Research Paper

Oncogenic effects of urotensin-II in cells lacking tuberous sclerosis complex-2 Research Paper

VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation Research Paper

mTORC1-mediated downregulation of COX2 restrains tumor growth caused by TSC2 deficiency Research Paper

PI3K/Akt promotes feedforward mTORC2 activation through IKKÎ± Priority Research Paper

Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus Research Paper

Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells Research Paper

Point mutations of the mTOR-RHEB pathway in renal cell carcinoma Priority Research Paper

AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf & TSC1/TSC2 Research Paper

A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation Research Paper

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

Targeting Rb mutant cancers by inactivating TSC2 Research Perspective

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells Research Paper

PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide Research Paper

Curcumin targets the TFEB-lysosome pathway for induction of autophagy Research Paper

Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation Research Paper

Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancer Research Paper

Oncogenic effects of urotensin-II in cells lacking tuberous sclerosis complex-2 Research Paper

VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation Research Paper

mTORC1-mediated downregulation of COX2 restrains tumor growth caused by TSC2 deficiency Research Paper

PI3K/Akt promotes feedforward mTORC2 activation through IKKÎ± Priority Research Paper

Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus Research Paper

Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells Research Paper

Point mutations of the mTOR-RHEB pathway in renal cell carcinoma Priority Research Paper

AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf & TSC1/TSC2 Research Paper

A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation Research Paper

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

Targeting Rb mutant cancers by inactivating TSC2 Research Perspective