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Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1 Research Paper

Camille Jacques, FranÃ§ois Lamoureux, Marc Baudâ€™huin, Lidia Rodriguez Calleja, Thibaut Quillard, JÃ©rÃ´me Amiaud, Franck Tirode, FranÃ§oise RÃ©dini, James E. Bradner, Dominique Heymann, Benjamin Ory

Published Mar 19, 2016 · Vol. 7, No. 17 · pp. 24125-24140

The RNA helicase A in malignant transformation Review

Marco Fidaleo, Elisa De Paola, Maria Paola Paronetto

Published Feb 14, 2016 · Vol. 7, No. 19 · pp. 28711-28723

Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting Review

Emily R. Theisen, Kathleen I. Pishas, Ranajeet S. Saund, Stephen L. Lessnick

Published Feb 2, 2016 · Vol. 7, No. 14 · pp. 17616-17630

The second European interdisciplinary Ewing sarcoma research summit â€“ A joint effort to deconstructing the multiple layers of a complex disease Review

Heinrich Kovar, James Amatruda, Erika Brunet, Stefan Burdach, Florencia Cidre-Aranaz, Enrique de Alava, Uta Dirksen, Wietske van der Ent, Patrick Grohar, Thomas G. P. GrÃ¼newald, Lee Helman, Peter Houghton, Kristiina Iljin, Eberhard Korsching, Marc Ladanyi, Elizabeth Lawlor, Stephen Lessnick, Joseph Ludwig, Paul Meltzer, Markus Metzler, Jaume Mora, Richard Moriggl, Takuro Nakamura, Theodore Papamarkou, Branka Radic Sarikas, Francoise RÃ©dini, Guenther H. S. Richter, Claudia Rossig, Keri Schadler, Beat W. SchÃ¤fer, Katia Scotlandi, Nathan C. Sheffield, Anang Shelat, Ewa Snaar-Jagalska, Poul Sorensen, Kimberly Stegmaier, Elizabeth Stewart, Alejandro Sweet-Cordero, Karoly Szuhai, Oscar M. Tirado, Franck Tirode, Jeffrey Toretsky, Kalliopi Tsafou, Aykut Ãœren, Andrei Zinovyev, Olivier Delattre

Published Jan 18, 2016 · Vol. 7, No. 8 · pp. 8613-8624

Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma Research Paper

Tim Hensel, Chiara Giorgi, Oxana Schmidt, Julia Calzada-Wack, Frauke Neff, Thorsten Buch, Felix K. Niggli, Beat W. SchÃ¤fer, Stefan Burdach, GÃ¼nther H.S. Richter

Published Nov 25, 2015 · Vol. 7, No. 2 · pp. 1451-1463

YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model Research Paper

Tsion Zewdu Minas, Jenny Han, Tahereh Javaheri, Sung-Hyeok Hong, Michaela Schlederer, Yasemin SaygideÄŸer-Kont, Haydar Ã‡elik, Kristina M. Mueller, Idil Temel, Metin Ã–zdemirli, Heinrich Kovar, Hayriye Verda Erkizan, Jeffrey Toretsky, Lukas Kenner, Richard Moriggl, Aykut Ãœren

Published Oct 8, 2015 · Vol. 6, No. 35 · pp. 37678-37694

Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9 Research Paper

Marco Fidaleo, Francesca Svetoni, Elisabetta Volpe, BelÃ©n MiÃ±ana, Daniela Caporossi, Maria Paola Paronetto

Published Oct 2, 2015 · Vol. 6, No. 31 · pp. 31740-31757

The association between let-7, RAS and HIF-1Î± in Ewing Sarcoma tumor growth Research Paper

Michal Hameiri-Grossman, Adi Porat-Klein, Isaac Yaniv, Shifra Ash, Ian J. Cohen, Yona Kodman, Ronit Haklai, Galit Elad-Sfadia, Yoel Kloog, Elena Chepurko, Meora Feinmesser, Josephine Issakov, Osnat Sher, Drorit Luria, Yehuda Kollender, Avraham Weizman, Smadar Avigad

Published Sep 10, 2015 · Vol. 6, No. 32 · pp. 33834-33848

PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1 Research Paper

Chiara Giorgi, Aleksandar Boro, Florian Rechfeld, Laura A. Lopez-Garcia, Maria E. Gierisch, Beat W. SchÃ¤fer, Felix K. Niggli

Published Aug 22, 2015 · Vol. 6, No. 30 · pp. 28895-28910

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma Research Paper

Alyssa L. Kennedy, Mounica Vallurupalli, Liying Chen, Brian Crompton, Glenn Cowley, Francisca Vazquez, Barbara A. Weir, Aviad Tsherniak, Sudha Parasuraman, Sunkyu Kim, Gabriela Alexe, Kimberly Stegmaier

Published Aug 18, 2015 · Vol. 6, No. 30 · pp. 30178-30193

Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer Research Paper

Wei Song, Wei Li, Lingyu Li, Shilin Zhang, Xu Yan, Xue Wen, Xiaoying Zhang, Huimin Tian, Ailing Li, Ji-Fan Hu, Jiuwei Cui

Published Jun 24, 2015 · Vol. 6, No. 27 · pp. 23764-23775

Keywords: Breast cancer, metastasis, FLI1, Rho GTPase pathway, oncogene, gene expression

The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin Research Paper

JosÃ© Luis OrdÃ³Ã±ez, Ana Teresa Amaral, Angel M. Carcaboso, David Herrero-MartÃn, MarÃa del Carmen GarcÃa-MacÃas, Vicky Sevillano, Diego Alonso, Guillem Pascual-Pasto, Laura San-Segundo, Monica Vila-Ubach, Telmo Rodrigues, Susana Fraile, Cristina Teodosio, AgustÃn Mayo-Iscar, Miguel Aracil, Carlos MarÃa Galmarini, Oscar M. Tirado, Jaume Mora, Enrique de Ãlava

Published May 27, 2015 · Vol. 6, No. 22 · pp. 18875-18890

By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer Research Paper

Qing Zhang, Yanyan Song, Wei Chen, Xiaohui Wang, Zhifeng Miao, Liu Cao, Feng Li, Guiling Wang

Published May 8, 2015 · Vol. 6, No. 18 · pp. 16461-16470

PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis Research Paper

Guiling Wang, Yanyan Song, Tong Liu, Chunyu Wang, Qing Zhang, Furong Liu, Xinze Cai, Zhifeng Miao, Hongde Xu, Huimian Xu, Liu Cao, Feng Li

Published Mar 21, 2015 · Vol. 6, No. 12 · pp. 9877-9886

High neuropeptide Y release associates with Ewing sarcoma bone dissemination - in vivo model of site-specific metastases Research Paper

Sung-Hyeok Hong, Jason U. Tilan, Susana Galli, Ewa Izycka-Swieszewska, Taylor Polk, Meredith Horton, Akanksha Mahajan, David Christian, Shari Jenkins, Rachel Acree, Katherine Connors, Phuong Ledo, Congyi Lu, Yi-Chien Lee, Olga Rodriguez, Jeffrey A. Toretsky, Chris Albanese, Joanna Kitlinska

Published Jan 30, 2015 · Vol. 6, No. 9 · pp. 7151-7165

GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signaling Research Paper

Yang Li, Qiang Ke, Yangguang Shao, Ge Zhu, Yanshu Li, Nanxi Geng, Feng Jin, Feng Li

Published Jan 21, 2015 · Vol. 6, No. 6 · pp. 4345-4356

Novel mechanism of JNK pathway activation by adenoviral E1A Research Paper

Vasily S. Romanov, Anna I. Brichkina, Helen Morrison, Tatiana V. Pospelova, Valery A. Pospelov, Peter Herrlich

Published Mar 25, 2014 · Vol. 5, No. 8 · pp. 2176-2186

Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects Research Paper

Jason U. Tilan, Congyi Lu, Susana Galli, Ewa Izycka-Swieszewska, Joshua P. Earnest, Asim Shabbir, Lindsay M. Everhart, Shuo Wang, Samantha Martin, Meredith Horton, Akanksha Mahajan, David Christian, Alison O'Neill, Hongkun Wang, Tingting Zhuang, Magdalena Czarnecka, Michael D. Johnson, Jeffrey A. Toretsky, Joanna B. Kitlinska

Published Nov 26, 2013 · Vol. 4, No. 12 · pp. 2487-2501

Keywords: Neuropeptide Y, Ewing sarcoma, hypoxia, cancer stem cells, angiogenesis

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Sung-Hyeok Hong, Sarah E. Youbi, S. Peter Hong, Bhaskar Kallakury, Phillip Monroe, Hayriye V. Erkizan, Julie S. Barber-Rotenberg, Peter Houghton, Aykut Ãœren, Jeffrey A. Toretsky

Published Nov 11, 2013 · Vol. 5, No. 2 · pp. 338-350

Keywords: YK-4-279, EWS-FLI1, Ewing Sarcoma, rat xenograft, pharmacokinetic modeling

Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1 Research Paper

Julie S. Barber-Rotenberg, Saravana P. Selvanathan, Yali Kong, Hayriye V. Erkizan, Tara M. Snyder, S. Peter Hong, Christina L. Kobs, Natalie L. South, Steven Summer, Philip J. Monroe, Maksymilian Chruszcz, Veselin Dobrev, Perrer N. Tosso, Lauren J. Scher, Wladek Minor, Milton L. Brown, Steven J. Metallo, Aykut Ãœren, Jeffrey A. Toretsky

Published Feb 29, 2012 · Vol. 3, No. 2 · pp. 172-182

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Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1 Research Paper

The RNA helicase A in malignant transformation Review

Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting Review

The second European interdisciplinary Ewing sarcoma research summit â€“ A joint effort to deconstructing the multiple layers of a complex disease Review

Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma Research Paper

YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model Research Paper

Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9 Research Paper

The association between let-7, RAS and HIF-1Î± in Ewing Sarcoma tumor growth Research Paper

PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1 Research Paper

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma Research Paper

Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer Research Paper

The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin Research Paper

By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer Research Paper

PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis Research Paper

High neuropeptide Y release associates with Ewing sarcoma bone dissemination - in vivo model of site-specific metastases Research Paper

GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signaling Research Paper

Novel mechanism of JNK pathway activation by adenoviral E1A Research Paper

Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects Research Paper

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1 Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1 Research Paper

The RNA helicase A in malignant transformation Review

Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting Review

The second European interdisciplinary Ewing sarcoma research summit â€“ A joint effort to deconstructing the multiple layers of a complex disease Review

Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma Research Paper

YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model Research Paper

Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9 Research Paper

The association between let-7, RAS and HIF-1Î± in Ewing Sarcoma tumor growth Research Paper

PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1 Research Paper

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma Research Paper

Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer Research Paper

The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin Research Paper

By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer Research Paper

PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis Research Paper

High neuropeptide Y release associates with Ewing sarcoma bone dissemination - in vivo model of site-specific metastases Research Paper

GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signaling Research Paper

Novel mechanism of JNK pathway activation by adenoviral E1A Research Paper

Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects Research Paper

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1 Research Paper