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Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting Review

Emily R. Theisen, Kathleen I. Pishas, Ranajeet S. Saund, Stephen L. Lessnick

Published Feb 2, 2016 · Vol. 7, No. 14 · pp. 17616-17630

The second European interdisciplinary Ewing sarcoma research summit â€“ A joint effort to deconstructing the multiple layers of a complex disease Review

Heinrich Kovar, James Amatruda, Erika Brunet, Stefan Burdach, Florencia Cidre-Aranaz, Enrique de Alava, Uta Dirksen, Wietske van der Ent, Patrick Grohar, Thomas G. P. GrÃ¼newald, Lee Helman, Peter Houghton, Kristiina Iljin, Eberhard Korsching, Marc Ladanyi, Elizabeth Lawlor, Stephen Lessnick, Joseph Ludwig, Paul Meltzer, Markus Metzler, Jaume Mora, Richard Moriggl, Takuro Nakamura, Theodore Papamarkou, Branka Radic Sarikas, Francoise RÃ©dini, Guenther H. S. Richter, Claudia Rossig, Keri Schadler, Beat W. SchÃ¤fer, Katia Scotlandi, Nathan C. Sheffield, Anang Shelat, Ewa Snaar-Jagalska, Poul Sorensen, Kimberly Stegmaier, Elizabeth Stewart, Alejandro Sweet-Cordero, Karoly Szuhai, Oscar M. Tirado, Franck Tirode, Jeffrey Toretsky, Kalliopi Tsafou, Aykut Ãœren, Andrei Zinovyev, Olivier Delattre

Published Jan 18, 2016 · Vol. 7, No. 8 · pp. 8613-8624

Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma Research Paper

Tim Hensel, Chiara Giorgi, Oxana Schmidt, Julia Calzada-Wack, Frauke Neff, Thorsten Buch, Felix K. Niggli, Beat W. SchÃ¤fer, Stefan Burdach, GÃ¼nther H.S. Richter

Published Nov 25, 2015 · Vol. 7, No. 2 · pp. 1451-1463

YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model Research Paper

Tsion Zewdu Minas, Jenny Han, Tahereh Javaheri, Sung-Hyeok Hong, Michaela Schlederer, Yasemin SaygideÄŸer-Kont, Haydar Ã‡elik, Kristina M. Mueller, Idil Temel, Metin Ã–zdemirli, Heinrich Kovar, Hayriye Verda Erkizan, Jeffrey Toretsky, Lukas Kenner, Richard Moriggl, Aykut Ãœren

Published Oct 8, 2015 · Vol. 6, No. 35 · pp. 37678-37694

Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9 Research Paper

Marco Fidaleo, Francesca Svetoni, Elisabetta Volpe, BelÃ©n MiÃ±ana, Daniela Caporossi, Maria Paola Paronetto

Published Oct 2, 2015 · Vol. 6, No. 31 · pp. 31740-31757

The association between let-7, RAS and HIF-1Î± in Ewing Sarcoma tumor growth Research Paper

Michal Hameiri-Grossman, Adi Porat-Klein, Isaac Yaniv, Shifra Ash, Ian J. Cohen, Yona Kodman, Ronit Haklai, Galit Elad-Sfadia, Yoel Kloog, Elena Chepurko, Meora Feinmesser, Josephine Issakov, Osnat Sher, Drorit Luria, Yehuda Kollender, Avraham Weizman, Smadar Avigad

Published Sep 10, 2015 · Vol. 6, No. 32 · pp. 33834-33848

PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1 Research Paper

Chiara Giorgi, Aleksandar Boro, Florian Rechfeld, Laura A. Lopez-Garcia, Maria E. Gierisch, Beat W. SchÃ¤fer, Felix K. Niggli

Published Aug 22, 2015 · Vol. 6, No. 30 · pp. 28895-28910

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma Research Paper

Alyssa L. Kennedy, Mounica Vallurupalli, Liying Chen, Brian Crompton, Glenn Cowley, Francisca Vazquez, Barbara A. Weir, Aviad Tsherniak, Sudha Parasuraman, Sunkyu Kim, Gabriela Alexe, Kimberly Stegmaier

Published Aug 18, 2015 · Vol. 6, No. 30 · pp. 30178-30193

The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin Research Paper

JosÃ© Luis OrdÃ³Ã±ez, Ana Teresa Amaral, Angel M. Carcaboso, David Herrero-MartÃn, MarÃa del Carmen GarcÃa-MacÃas, Vicky Sevillano, Diego Alonso, Guillem Pascual-Pasto, Laura San-Segundo, Monica Vila-Ubach, Telmo Rodrigues, Susana Fraile, Cristina Teodosio, AgustÃn Mayo-Iscar, Miguel Aracil, Carlos MarÃa Galmarini, Oscar M. Tirado, Jaume Mora, Enrique de Ãlava

Published May 27, 2015 · Vol. 6, No. 22 · pp. 18875-18890

Endoplasmic reticulum targeting in Ewingâ€™s sarcoma by the alkylphospholipid analog edelfosine Research Paper

Ximena Bonilla, EL-Habib Dakir, Faustino Mollinedo, Consuelo Gajate

Published May 9, 2015 · Vol. 6, No. 16 · pp. 14596-14613

CD44 enhances tumor aggressiveness by promoting tumor cell plasticity Research Paper

Yvette W.J. Paulis, Elisabeth J.M. Huijbers, Daisy W.J. van der Schaft, Patricia M.M.B. Soetekouw, Patrick Pauwels, Vivianne C.G. Tjan-Heijnen, Arjan W. Griffioen

Published Apr 15, 2015 · Vol. 6, No. 23 · pp. 19634-19646

High neuropeptide Y release associates with Ewing sarcoma bone dissemination - in vivo model of site-specific metastases Research Paper

Sung-Hyeok Hong, Jason U. Tilan, Susana Galli, Ewa Izycka-Swieszewska, Taylor Polk, Meredith Horton, Akanksha Mahajan, David Christian, Shari Jenkins, Rachel Acree, Katherine Connors, Phuong Ledo, Congyi Lu, Yi-Chien Lee, Olga Rodriguez, Jeffrey A. Toretsky, Chris Albanese, Joanna Kitlinska

Published Jan 30, 2015 · Vol. 6, No. 9 · pp. 7151-7165

miR-125a-5p is a prognostic biomarker that targets HDAC4 to suppress breast tumorigenesis Research Paper

Tsung-Hua Hsieh, Chia-Yi Hsu, Cheng-Fang Tsai, Cheng-Yu Long, Chee-Yin Chai, Ming-Feng Hou, Jau-Nan Lee, Deng-Chyang Wu, Shao-Chun Wang, Eing-Mei Tsai

Published Nov 28, 2014 · Vol. 6, No. 1 · pp. 494-509

Keywords: miR-125a-5p, HDAC4, Tumorigenesis and breast cancer

The role of AXL and the in vitro activity of the receptor tyrosine kinase inhibitor BGB324 in Ewing sarcoma Research Paper

Emmy D.G. Fleuren, Melissa H.S. Hillebrandt-Roeffen, Uta E. Flucke, D. Maroeska W.M. te Loo, Otto C. Boerman, Winette T.A. van der Graaf, Yvonne M.H. Versleijen-Jonkers

Published Nov 15, 2014 · Vol. 5, No. 24 · pp. 12753-12768

WT1 regulates angiogenesis in Ewing Sarcoma Research Paper

Varalakshimi Katuri, Stephanie Gerber, Xiaofei Qiu, Gregory McCarty, Seth D. Goldstein, Hans Hammers, Elizabeth Montgomery, Allen R. Chen, David M. Loeb

Published Feb 3, 2014 · Vol. 5, No. 9 · pp. 2436-2449

Keywords: tumor angiogenesis, transcriptional regulation, tissue microarray, vascularity, alternative splicing

Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects Research Paper

Jason U. Tilan, Congyi Lu, Susana Galli, Ewa Izycka-Swieszewska, Joshua P. Earnest, Asim Shabbir, Lindsay M. Everhart, Shuo Wang, Samantha Martin, Meredith Horton, Akanksha Mahajan, David Christian, Alison O'Neill, Hongkun Wang, Tingting Zhuang, Magdalena Czarnecka, Michael D. Johnson, Jeffrey A. Toretsky, Joanna B. Kitlinska

Published Nov 26, 2013 · Vol. 4, No. 12 · pp. 2487-2501

Keywords: Neuropeptide Y, Ewing sarcoma, hypoxia, cancer stem cells, angiogenesis

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Sung-Hyeok Hong, Sarah E. Youbi, S. Peter Hong, Bhaskar Kallakury, Phillip Monroe, Hayriye V. Erkizan, Julie S. Barber-Rotenberg, Peter Houghton, Aykut Ãœren, Jeffrey A. Toretsky

Published Nov 11, 2013 · Vol. 5, No. 2 · pp. 338-350

Keywords: YK-4-279, EWS-FLI1, Ewing Sarcoma, rat xenograft, pharmacokinetic modeling

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper

Yunyun Jiang, Filip Janku, Vivek Subbiah, Laura S. Angelo, Aung Naing, Peter M. Anderson, Cynthia E. Herzog, Siqing Fu, Robert S. Benjamin, Razelle Kurzrock

Published Jun 5, 2013 · Vol. 4, No. 6 · pp. 884-889

Keywords: Ewing sarcoma, PTPRD, mutation, germline

Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo Research Paper

Shuang Yan, Zhijie Li, Carol J Thiele

Published Mar 19, 2013 · Vol. 4, No. 3 · pp. 433-445

Keywords: neuroblastoma, Ewing sarcoma, rhabdomyosarcoma, JAK inhibitor, STAT3

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting Review

The second European interdisciplinary Ewing sarcoma research summit â€“ A joint effort to deconstructing the multiple layers of a complex disease Review

Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma Research Paper

YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model Research Paper

Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9 Research Paper

The association between let-7, RAS and HIF-1Î± in Ewing Sarcoma tumor growth Research Paper

PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1 Research Paper

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma Research Paper

The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin Research Paper

Endoplasmic reticulum targeting in Ewingâ€™s sarcoma by the alkylphospholipid analog edelfosine Research Paper

CD44 enhances tumor aggressiveness by promoting tumor cell plasticity Research Paper

High neuropeptide Y release associates with Ewing sarcoma bone dissemination - in vivo model of site-specific metastases Research Paper

miR-125a-5p is a prognostic biomarker that targets HDAC4 to suppress breast tumorigenesis Research Paper

The role of AXL and the in vitro activity of the receptor tyrosine kinase inhibitor BGB324 in Ewing sarcoma Research Paper

WT1 regulates angiogenesis in Ewing Sarcoma Research Paper

Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects Research Paper

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper

Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting Review

The second European interdisciplinary Ewing sarcoma research summit â€“ A joint effort to deconstructing the multiple layers of a complex disease Review

Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma Research Paper

YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model Research Paper

Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9 Research Paper

The association between let-7, RAS and HIF-1Î± in Ewing Sarcoma tumor growth Research Paper

PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1 Research Paper

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma Research Paper

The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin Research Paper

Endoplasmic reticulum targeting in Ewingâ€™s sarcoma by the alkylphospholipid analog edelfosine Research Paper

CD44 enhances tumor aggressiveness by promoting tumor cell plasticity Research Paper

High neuropeptide Y release associates with Ewing sarcoma bone dissemination - in vivo model of site-specific metastases Research Paper

miR-125a-5p is a prognostic biomarker that targets HDAC4 to suppress breast tumorigenesis Research Paper

The role of AXL and the in vitro activity of the receptor tyrosine kinase inhibitor BGB324 in Ewing sarcoma Research Paper

WT1 regulates angiogenesis in Ewing Sarcoma Research Paper

Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects Research Paper

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper

Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo Research Paper