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Oncotarget: Innovating & expanding weight loss strategies for breast cancer survivors


FOR IMMEDIATE RELEASE
2021-11-19

Oncotarget published "Innovating and expanding weight loss strategies for breast cancer survivors" which reported that overweight and obesity are prevalent in over two thirds of the general population in the United States and are associated with an increased risk of malignancies, including breast cancer.

This weight gain may increase risk of recurrence by 40–50%, and breast cancer-related mortality by 53–60% . Obesity at and following a breast cancer diagnosis is associated with poor quality of life and increased risk of adverse treatment effects.

Dr. Jennifer Y. Sheng from The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center said, "...survivorship guidelines recommend that weight loss should be a priority for overweight/obese survivors."

...survivorship guidelines recommend that weight loss should be a priority for overweight/obese survivors.

Numerous clinical trials have tested behavioral strategies for weight loss in survivors of early stage breast cancer, including modifications in diet, remote or group interventions. These authors evaluated several outcomes including: whether a 12-month remotely delivered behavioral weight loss intervention allows a greater proportion of breast cancer survivors to achieve 5% weight compared to a self-directed approach, modulation of biomarkers of cancer risk including metabolism, inflammation, and telomere length, and changes in patient-reported outcomes.

While levels of inflammatory cytokines improved, changes were not statistically significant. However, studies show that weight loss of 10% has been associated with modulation of serum and tissue biomarkers, such as Ki-67, adiponectin, adiponectin to leptin ratio, sex hormone binding globulin, estradiol, testosterone and insulin.

The Sheng Research Team concluded in their Oncotarget Research Output that as there may be barriers to in-person or group interventions and studies aim for scalability, we can expect remote interventions like POWER-remote to be used as a practical strategy for weight loss.

Figure 1: The impact of obesity at and following a breast cancer diagnosis.

Remote strategies that incorporate a comprehensive assessment and coaching are necessary to ensure safe and cost effective treatment for cancer survivors struggling with weight loss.

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DOI - https://doi.org/10.18632/oncotarget.27898

Correspondence to - Jennifer Y. Sheng - jsheng7@jhmi.edu

Keywords - breast cancer, obesity, lifestyle interventions

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