Oncotarget

Research Papers:

Systemic immune-inflammation index, thymidine phosphorylase and survival of localized gastric cancer patients after curative resection

Liu Huang, Shan Liu, Yu Lei, Kun Wang, Min Xu, Yaobing Chen, Bo Liu, Yangyang Chen, Qiang Fu, Peng Zhang, Kai Qin, Yixin Cai, Shengling Fu, Shuwang Ge and Xianglin Yuan _

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Oncotarget. 2016; 7:44185-44193. https://doi.org/10.18632/oncotarget.9923

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Abstract

Liu Huang1, Shan Liu2, Yu Lei2, Kun Wang2, Min Xu1, Yaobing Chen3, Bo Liu1, Yangyang Chen1, Qiang Fu1, Peng Zhang1, Kai Qin1, Yixin Cai4, Shengling Fu4,*, Shuwang Ge5,*, Xianglin Yuan1,*

1Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China

2The Second Clinical College, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China

3Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China

4Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China

5Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China

*These authors contributed equally to this work

Correspondence to:

Xianglin Yuan, email: yxl@medmail.com.cn

Keywords: gastric cancer, systemic immune-inflammation index, thymidine phosphorylase, peripheral blood counts, survival

Received: February 24, 2016     Accepted: May 16, 2016     Published: June 8, 2016

ABSTRACT

Systemic immune-inflammation index (SII), based on lymphocyte (L), neutrophil (N), and platelet (P) counts, was recently developed and reflects comprehensively the balance of host inflammatory and immune status. We explored its prognostic value in localized gastric cancer (GC) after R0 resection and the potential associations with Thymidine phosphorylase (TYMP), which was reported to increase the migration and invasion of gastric cancer cells. A total of 455 GC patients who received D2 gastrectomy were enrolled. Blood samples were obtained within 1 week before surgery to measure SII (SII = P × N/L). TYMP expression was measured on tumor sections by immunohistochemical analysis. Preoperative high SII indicated worse prognosis (HR: 1.799; 95% CI: 1.174-2.757; p = 0.007) in multivariate analysis and was associated with higher pathological TNM stage, deeper local invasion of tumor and lymph node metastasis (all p < 0.001). SII predicted poor overall survival in pathological TNM stage I subgroup also (p < 0.001). Furthermore we found that in high SII group, positive rate of TYMP expression increased (53.7% vs 42.7%, p = 0.046) and TYMP positive patients had higher SII score (median 405.9 vs. 351.9, p = 0.026). SII, as a noninvasive and low cost prognostic marker, may be helpful to identify higher-risk patients after R0 resection, even for stage I GC patients.


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