Oncotarget

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Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis

Yang Chen, Jie Li and Zengnan Mo _

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Oncotarget. 2016; 7:52530-52540. https://doi.org/10.18632/oncotarget.9693

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Abstract

Yang Chen1,2,4,*, Jie Li1,3,* and Zengnan Mo1,2,4

1 Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China

2 Department of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China

3 Research Center for Guangxi Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, China

4. Guangxi key laboratory for genomic and personalized medicine, Guangxi collaborative innovation center for genomic and personalized medicine, Nanning, Guangxi Zhuang Autonomous Region, China

* These authors have contributed equally to this work

Correspondence to:

Zengnan Mo, email:

Keywords: APEX1, rs1130409, polymorphism, prostate cancer

Received: November 22, 2015 Accepted: May 16, 2016 Published: May 29, 2016

Abstract

Background: Prostate cancer (Pca) is a serious disease associated with considerable morbidity and mortality. As a causative factor, the Asp148Glu polymorphism has been identified in the apurinic/apyrimidinic endonuclease (APEX1) gene. However, the association among Asians is considered controversial.

Methods: Evidence for this association was obtained from the PubMed, Embase, HuGENet and Chinese National Knowledge Infrastructure (CNKI) databases. In the analysis, four models were applied. Associations between the APEX1 polymorphism and the invasiveness of Pca based on the Gleason score, prostate-specific antigen expression and clinical status were also evaluated.

Results: Seven articles were included in the analysis. Positive results were not only discovered in the pooled analysis, but also among patients of mixed descentand Asian descent. However, after considering the Hardy-Weinberg equilibrium (HWE), we observed only a 1.557-fold increase in Pca risk for subjects of Asian descent(GG vs. TT: OR=1.557, 95%CI=1.069-2.268) under the co-dominant model. Additionally, we did not also find any relationship between the APEX1 Asp148Glu polymorphism and invasive Pca risk.

Conclusion: On the basis of the function of the APEX1 Asp148Glu polymorphism, recent studies, and our results, we suggest that the APEX1 Asp148Glu polymorphism might be important in stimulating the development of Pca rather than its invasiveness in various populations, especially for Asians.


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