Research Papers:
Efficient role of IgH 3' regulatory region deficient Bcells in the development of oil granulomas
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Nour Ghazzaui1, Alexis Saintamand1, Hussein Issaoui1, Faten Saad1, Yves Denizot1
1Department of Immunology, CNRS UMR 7276, CRIBL, Université de Limoges, Limoges, France
Correspondence to:
Yves Denizot, email: [email protected]
Keywords: IgH 3′ regulatory region, knock-out mice, pristine, granulomas
Received: March 25, 2016 Accepted: April 29, 2016 Published: May 25, 2016
ABSTRACT
Functional B-cells are essential for the formation of oil granulomas. The IgH 3′ regulatory region (3′RR) activates important check-points during B-cell maturation. We investigated if 3′RR-deficient B-cells remain efficient to develop oil granulomas in response to pristine. B-cells expressing an IgH 3′RR-deficient allele were similarly recruited to wild type allele expressing B-cells in the granuloma. No differences were observed between 3′RR-deficient mice and control mice for granuloma numbers, cellular composition and ability to express mRNA transcripts for several pro- and anti-inflammatory cytokines. Altogether these results suggest a normal role for 3′RR-deficient B-cells in the development of an acute B-cell-mediated inflammatory response.