Oncotarget

Clinical Research Papers:

Characteristics and survival of patients with metachronous or synchronous double primary malignancies: breast and thyroid cancer

Li Zhang, Yansheng Wu, Fangfang Liu, Li Fu and Zhongsheng Tong _

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Oncotarget. 2016; 7:52450-52459. https://doi.org/10.18632/oncotarget.9547

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Abstract

Li Zhang1,*, Yansheng Wu2,*, Fangfang Liu3, Li Fu3 and Zhongsheng Tong1

1 Department of Breast Oncology, Key Laboratory of Breast Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P.R.China

2 Department of Maxillofacial and Otorhinolaryngology Head and Neck Surgery, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P.R. China

3 Department of Breast Cancer Pathology and Research Laboratory, Key Laboratory of Breast Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P.R. China

* These authors have contributed equally to the manuscript

Correspondence to:

Zhongsheng Tong, email:

Li Fu, email:

Keywords: breast cancer; thyroid cancer; double primary malignancies; clinicopathologic characteristics; prognosis

Received: February 23, 2016 Accepted: May 05, 2016 Published: May 20, 2016

Abstract

Background: Clinical experiences suggest that breast cancer (BC) and thyroid cancer (TC) occur metachronously or synchronously in a patient more frequently than it would by chance. This study was conducted to investigate the clinicopathological characteristics and survival of these double primary malignancies.

Methods: 18732 patients with first primary BC and 12877 female patients with first primary TC were performed in this retrospective case-controlled study. The control groups were matched with both age at diagnosis and time of surgery (±2 years). The clinicopathological factors, Overall survival (OS), and HRs were evaluated by SPSS.

Results: There were 91(0.49%) BC patients developed metachronous second primary TC (B-T group), and 117 (0.91%) TC patients developed metachronous second primary BC (T-B group).The expression of estrogen and progesterone receptors, and the value of Ki-67, were significantly higher in the B-T group than control. The median value of thyroid globulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) were higher in T-B group than control (p <0.05). The duration before second primary cancer was shorter for the B-T group than the T-B group (4.09 years vs. 5.82 years, p<0.001). B-T group patients showed poorer survival than BC only patients (p=0.044).

Conclusions: In general, the overall risk of the occurrence of a second primary TC or BC elevated highly in patients with BC or TC. Detailed mechanisms need to be studied to explore the association between these two cancers. Early detection and effective prevention for the first primary BC or TC patients are necessities for reducing the incidence of the second primary cancer and improving the OS.


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