Research Papers:

Superior mediastinal mature cystic teratoma with gastrointestinal adenocarcinoma transformation: Report of a case

Chen Lin, Yiqun Du, Yuan Li, Huijie Wang and Jianhua Chang _

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Oncotarget. 2016; 7:38392-38397. https://doi.org/10.18632/oncotarget.9532

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Chen Lin1,*, Yiqun Du1,*, Yuan Li2, Huijie Wang1, Jianhua Chang1

1Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P.R. China

2Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P.R. China

*These authors contributed equally to this work

Correspondence to:

Jianhua Chang, email: [email protected]

Huijie Wang, email: [email protected]

Keywords: germ cell tumors, teratoma with malignant transformation, FOLFIRI chemotherapy regimen, whole exome sequencing

Received: January 28, 2016     Accepted: April 26, 2016     Published: May 21, 2016


Presented herein is a case of mediastinal mature teratoma with adenocarcinomatous transformation predominantly composed of mucinous adenocarcinoma in a 25-year-old man. Disease progressed despite application of surgical removal, adjuvant radio- and chemotherapy. Further immunohistochemical stains indicated a gastrointestinal origin of the tumor. Consequently chemotherapy according to the FOLFIRI regimen was applied that resulted in good response. To our knowledge, this is the first report of a clinical remission from chemotherapy with the FOLFIRI regimen after comprehensive initial treatment with surgery, radio- and chemotherapy for a patient with teratoma with malignant transformation, highlighting the importance of choosing an appropriate chemotherapy regimen.

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