Oncotarget

Research Papers:

rs965513 polymorphism as a common risk marker is associated with papillary thyroid cancer

Fang Wang, Dehui Yan, Xu Ji, Jun Han, Meijun Chen, Hong Qiao and Shaojun Zhang _

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Oncotarget. 2016; 7:41336-41345. https://doi.org/10.18632/oncotarget.9324

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Abstract

Fang Wang1,*, Dehui Yan1,*, Xu Ji2,*, Jun Han3, Meijun Chen3, Hong Qiao3, Shaojun Zhang1

1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China

2Department of Otolaryngology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China

3Department of Endemic Disease, the Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China

*These authors contributed equally to this work

Correspondence to:

Shaojun Zhang, email: zhangshaojun@ems.hrbmu.edu.cn

Hong Qiao, email: qiaoh0823@sina.com

Keywords: thyroid cancer, genome-wide association studies, FOXE1, rs965513, meta-analysis

Received: November 06, 2015     Accepted: April 16, 2016     Published: May 12, 2016

ABSTRACT

Papillary thyroid cancer (PTC) is the most common type of thyroid cancer. With the rapid development of genome-wide association studies (GWAS), many genome variants associated with susceptibility to PTC have been identified, including the single nucleotide polymorphism rs965513 (9q22.33) near FOXE1. To evaluate the association between rs965513 and PTC in different ethnicities and countries, we conducted a meta-analysis using relatively large-scale samples from 23 studies (N = 163,136; 20,736 cases and 142,400 controls) by searching the PubMed and Google Scholar databases. Significant heterogeneity caused by different populations among the selected studies was observed. The A allele of rs965513 polymorphism was shown to be highly associated with risk of thyroid cancer, with odds ratios of 1.58 (95% CI 1.32–1.90) in all populations, 1.65 (95% CI 1.31–2.07)) in Caucasian populations and 1.49 in Asian populations. Compared to the dominant and recessive models, we observed the highest odds ratio (OR = 2.80, 95% CI 2.12–3.69) in the homozygous model. These results revealed that the rs965513 polymorphism is a risk factor for thyroid cancer


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