Long non-coding RNAs in normal and malignant hematopoiesis
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Lucia Nobili1, Marta Lionetti1 and Antonino Neri1
1 Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Hematology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy
Antonino Neri, email:
Keywords: long non-coding RNAs; hematopoiesis; hematological malignancies; transcriptional regulation; translation regulation
Received: March 09, 2016 Accepted: May 01, 2016 Published: May 11, 2016
Long non-coding RNAs (lncRNAs) are defined as ncRNAs of more than 200 nt in length. They are involved in a large spectrum of biological processes, such as maintenance of genome integrity, genomic imprinting, cell differentiation, and development by means of mechanisms that remain to be fully elucidated. Besides their role in normal cellular physiology, accumulating evidence has linked lncRNA expression and functions to cancer development and progression. In this review, we summarize and discuss what is known about their expression and roles in hematopoiesis with a particular focus on their cell-type speciﬁcity, functional interactions, and involvement in the pathobiology of hematological malignancies.
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