Research Papers: Gerotarget (Focus on Aging):

Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts

Wei-Jen Ting, Jaw-Ji Yang, Chia-Hua Kuo, Zi-Jun Xiao, Xin-Ze Lu, Yu-Lan Yeh, Cecilia-Hsuan Day, Su-Ying Wen, Vijaya PadmaViswanadha, Chong-He Jiang, Wei-Wen Kuo and Chih-Yang Huang _

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Oncotarget. 2016; 7:39017-39025. https://doi.org/10.18632/oncotarget.9176

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Wei-Jen Ting1,2, Jaw-Ji Yang3, Chia-Hua Kuo4, Zi-Jun Xiao5, Xin-Ze Lu5, Yu-Lan Yeh6,7, Cecilia-Hsuan Day8, Su-Ying Wen9,10, Vijaya PadmaViswanadha11, Chong-He Jiang1, Wei-Wen Kuo12,* and Chih-Yang Huang2,13,14,*

1 The Sixth Affiliated Hospital of Guangzhou Medical University, Guangdong, China

2 Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan

3 Institute of Medicine, School of Dentistry, Chung-Shan Medical University, Taichung, Taiwan

4 Department of Sports Sciences, University of Taipei, Taipei, Taiwan

5 National Taichung First Senior High School, Taichung, Taiwan

6 Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan

7 Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan

8 Department of Nursing, Mei Ho University, Pingtung, Taiwan

9 Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan

10 Department of Dermatology, Taipei City Hospital, Renai Branch, Taipei, Taiwan

11 Department of Biotechnology, Bharathiar University, Coimbatore, India

12 Department of Biological Science and Technology, China Medical University, Taichung, Taiwan

13 Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan

14 Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan

* These authors have contributed equally to this paper

Correspondence to:

Chih-Yang Huang, email:

Keywords: environmental tobacco smoke (ETS); Sirt-1; autophagy; Gerotarget

Received: November 02, 2015 Accepted: April 16, 2016 Published: May 04, 2016


Recently, a survey by the Centers for Disease Control and Prevention (CDC) reported that nearly 90% of U.S. adult smokers began smoking at the age of 18. This demonstrates that the exposure to environmental tobacco smoke (ETS) of youngsters today is changing from passive smoking to active smoking (direct inhalation of tobacco). In the current study, an investigation of ETS exposure in young C57BL mice was conducted. After 6 weeks of ETS exposure, the Sirt-1 protein level was decreased and cardiac autophagy was increased in C57BL mice. Furthermore, the IGF2R cardiac hypertrophy signaling pathway was also triggered, although cardiac apoptosis and hypertrophy were not induced. Youngsters’ desire to look more mature is one of the psychological factors that impacts smoking amongst young people. Our results suggest that though ETS exposure might cause cardiac autophagy amongst youngsters, the loss of the longevity Sirt-1 protein and the increase in IGF2R cardiac hypertrophy signaling could still promote heart diseases that are age-specific.

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