Oncotarget

Clinical Research Papers:

Prognostic significance of cancer family history for patients with gastric cancer: a single center experience from China

Xiaowen Liu, Hong Cai, Lin Yu, Hua Huang, Ziwen Long and Yanong Wang _

PDF  |  HTML  |  How to cite

Oncotarget. 2016; 7:37305-37318. https://doi.org/10.18632/oncotarget.9032

Metrics: PDF 1430 views  |   HTML 1683 views  |   ?  


Abstract

Xiaowen Liu1,2, Hong Cai1,2, Lin Yu2,3, Hua Huang1,2, Ziwen Long1,2 and Yanong Wang1,2

1 Department of Gastric Cancer and Soft Tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai, China

2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

3 Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China

Correspondence to:

Yanong Wang, email:

Keywords: gastric cancer; prognosis; cancer family history

Received: December 16, 2015 Accepted: April 16, 2016 Published: April 26, 2016

Abstract

Family history of cancer is a risk factor for gastric cancer. In this study, we investigated the prognoses of gastric cancer patients with family history of cancer. A total of 1805 gastric cancer patients who underwent curative gastrectomy from 2000 to 2008 were evaluated. The clinicopathologic parameters and prognoses of gastric cancer patients with a positive family history (PFH) of cancer were compared with those with a negative family history (NFH). Of 1805 patients, 382 (21.2%) patients had a positive family history of cancer. Positive family history of cancer correlated with younger age, more frequent alcohol and tobacco use, worse differentiation, smaller tumor size, and more frequent tumor location in the lower 1/3 of the stomach. The prognoses of patients with a positive family history of cancer were better than that of patients with a negative family history. Family history of cancer independently correlated with better prognosis after curative gastrectomy in gastric cancer patients.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 9032