Complications in multiple gestation pregnancy: A cross-sectional study of ten maternal-fetal medicine centers in China
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Jun Wei1, Qi-Jun Wu2, Tie-Ning Zhang3, Zi-Qi Shen1, Hao Liu1, Dong-Ming Zheng1, Hong Cui1, Collaborative Group on Twin Birth and Fetal Abnormality in China, Cai-Xia Liu1
1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
2Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China
3Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China
Cai-Xia Liu, e-mail: [email protected]
Keywords: China, cross-sectional study, multiple births, pregnancy complications
Received: January 10, 2016 Accepted: April 02, 2016 Published: April 26, 2016
Complications in women with multiple gestation pregnancy have not been studied in China. We aimed to establish a database of women with multiple gestation pregnancy and investigate the complications related to multiple pregnancy. We conducted a cross-sectional study that included 3246 women with multiple gestation pregnancy and who had multiple live-birth deliveries; the women were registered at ten maternal-fetal medicine centers in China in 2013. All participants completed a detailed questionnaire that included basic demographic information, history of gestation and abnormal fetal development, risk factors during pregnancy, and pregnancy outcomes. Overall, 1553 (47.8%) women experienced pregnancy complications; these women were more likely to have lower height and less education than women who did not experience complications. However, women who experienced complications had a higher twin birth rate and were more likely to have received regular antenatal care and assisted reproductive technology than women without complications (P < 0.05). Notably, preterm birth was a primary complication in multiple pregnancy (n = 960). In conclusion, pregnancy complications, especially preterm birth, were relatively common in women with multiple gestation pregnancy. The findings from this cross-sectional study in China may be used as a foundation for investigating risk factors for complications in women with multiple gestation pregnancy in the future.
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