Dysregulation and functional roles of miR-183-96-182 cluster in cancer cell proliferation, invasion and metastasis

Yi Ma _, A-Juan Liang, Yu-Ping Fan, Yi-Ran Huang, Xiao-Ming Zhao, Yun Sun and Xiang-Feng Chen

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Oncotarget. 2016; 7:42805-42825. https://doi.org/10.18632/oncotarget.8715

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Yi Ma1,2, A-Juan Liang1,2, Yu-Ping Fan3, Yi-Ran Huang4, Xiao-Ming Zhao1,2, Yun Sun1,2 and Xiang-Feng Chen1,2,4

1 Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

2 Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China

3 Reproductive Medicine Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China

4 Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

Correspondence to:

Yun Sun, email:

Xiang-Feng Chen, email:

Keywords: miR-183-96-182 cluster, cancer development, cancer progression, metastasis, prognosis

Received: November 17, 2015 Accepted: March 31, 2016 Published: April 12, 2016


Previous studies have reported aberrant expression of the miR-183-96-182 cluster in a variety of tumors, which indicates its’ diagnostic or prognostic value. However, a key characteristic of the miR-183-96-182 cluster is its varied expression levels, and pleomorphic functional roles in different tumors or under different conditions. In most tumor types, the cluster is highly expressed and promotes tumorigenesis, cancer progression and metastasis; yet tumor suppressive effects have also been reported in some tumors. In the present study, we discuss the upstream regulators and the downstream target genes of miR-183-96-182 cluster, and highlight the dysregulation and functional roles of this cluster in various tumor cells. Newer insights summarized in this review will help readers understand the different facets of the miR-183-96-182 cluster in cancer development and progression.

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