Oncotarget

Research Papers:

Prognostic role of high B7-H4 expression in patients with solid tumors: a meta-analysis

Xing Song, Yingjie Shao, Wendong Gu, Chao Xu, Huihui Mao, Honglei Pei and Jingting Jiang _

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Oncotarget. 2016; 7:76523-76533. https://doi.org/10.18632/oncotarget.8598

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Abstract

Xing Song1,*, Yingjie Shao1,*, Wendong Gu1, Chao Xu2, Huihui Mao2, Honglei Pei1, Jingting Jiang3

1Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People’s Republic of China

2Department of Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People’s Republic of China

3Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People’s Republic of China

*These authors have contributed equally to this work

Correspondence to:

Honglei Pei, email: [email protected]

Jingting Jiang, email: [email protected]

Keywords: B7-H4, prognosis, solid tumor, biomarker, meta-analysis

Received: December 30, 2015     Accepted: March 28, 2016     Published: April 05, 2016

ABSTRACT

Background: Recently, many studies have shown that B7-H4 exhibits altered expression in various cancers. We performed a meta-analysis to evaluate the prognostic role of B7-H4 expression in solid tumors.

Results: Data from 18 observational studies and 2467 patients were summarized. An elevated baseline B7-H4 was significantly associated with worse OS (pooled HR = 1.79; 95% CI = 1.56–2.06). Differences across subgroups of tumor type, patients’ ethnicity, analysis type, HR obtain method and cut-off value were not significant (PD = 0.313, PD = 0.716, PD = 0.896, PD = 0.290 and PD = 0.153, respectively). Furthermore, patients with high B7-H4 had a significantly shorter DFS (pooled HR = 2.12; 95%CI = 1.45–3.09).

Materials and Methods: We searched PubMed, Embase and the Cochrane Library (last update by November 26, 2015) to identify studies assessing the effect of B7-H4 on survival of cancer patients. Pooled hazard ratios (HRs) for overall survival (OS) and disease-free survival (DFS) were estimated using fixed-effects models and random-effects models respectively.

Conclusions: This meta-analysis clarified that high B7-H4 expression in tissue was significantly associated with poor survival in patients with solid tumors. Future clinical studies are warranted to determine whether B7-H4 blockade has a favorable effect on disease recurrence and mortality.


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