Oncotarget

Research Papers:

Protein profiling of alpha-fetoprotein producing gastric adenocarcinoma

Liang He, Fei Ye, Linlin Qu, Daguang Wang, Miao Cui, Chengguo Wei, Yanpeng Xing, Peng Lee, Jian Suo and David Y. Zhang _

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Oncotarget. 2016; 7:28448-28459. https://doi.org/10.18632/oncotarget.8571

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Abstract

Liang He1, Fei Ye2, Linlin Qu3, Daguang Wang1, Miao Cui2, Chengguo Wei4, Yanpeng Xing1, Peng Lee5, Jian Suo1, David Y. Zhang2

1Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, China

2Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

3Department of Clinical Laboratory, First Hospital of Jilin University, Changchun, China

4Department of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

5Department of Pathology, New York University School of Medicine, New York, NY, USA

Correspondence to:

Jian Suo, email: [email protected]

David Y. Zhang, email: [email protected]

Keywords: AFP, gastric cancer, signaling pathways, survival analysis

Received: December 01, 2015     Accepted: February 28, 2016     Published: April 4, 2016

ABSTRACT

Alpha-fetoprotein (AFP) producing gastric adenocarcinoma is considered as a rare subtype of gastric adenocarcinoma. Compared with AFP non-producing gastric adenocarcinoma, our study and other previous studies showed that AFP producing gastric adenocarcinoma is more aggressive and prone to liver metastasis. Using the Protein Pathway Array, 11 of out of 286 proteins tested were found to be differentially expressed between AFP producing (n=32) and AFP non-producing (n=45) gastric adenocarcinoma tissues. In addition, the high level expression of XIAP and IGF-Irβ in gastric adenocarcinoma tissues was independent factors for poor prognosis in AFP producing gastric adenocarcinoma patients. A risk model based on the XIAP and IGF-Irβ expression levels can separate AFP producing gastric adenocarcinoma patients into 2 subgroups and each subgroup had a distinct set of signaling pathways involved. In conclusion, AFP producing gastric adenocarcinoma is a heterogeneous cancer with different clinical outcomes, biological behaviors and underlying molecular alterations.


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