Oncotarget

Research Papers:

Genetic variants of lncRNA HOTAIR and risk of epithelial ovarian cancer among Chinese women

Haijing Wu, Xiaofei Shang, Yu Shi, Zhirong Yang, Jun Zhao, Min Yang, Yan Li and Shiqiang Xu _

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Oncotarget. 2016; 7:41047-41052. https://doi.org/10.18632/oncotarget.8535

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Abstract

Haijing Wu1, Xiaofei Shang1, Yu Shi1, Zhirong Yang1, Jun Zhao1, Min Yang1, Yan Li2, Shiqiang Xu1

1Department of Gynecologic Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, People’s Republic of China

2The First Affiliated Hospital, Nanchang University, Nanchang, People’s Republic of China

Correspondence to:

Shiqiang Xu, email: xu_shiqiang@126.com

Keywords: long noncoding RNA, HOTAIR, genetic variants, ovarian cancer

Received: November 22, 2015     Accepted: April 19, 2016     Published: April 28, 2016

ABSTRACT

Ovarian cancer is one of the common female malignant tumors globally. However, exactly mechanism of ovarian cancer remained unknown. HOTAIR, a lncRNA in the mammalian HOXC locus, has been fully explored for its genetic variants, expression level and carcinogenesis, development and progression of multiple cancers, except for ovarian cancer. In this study, we hypothesized that abnormal expression of HOTAIR and common variants of HOTAIR are associated with risk of Epithelial ovarian cancer (EOC). We first evaluated the HOTAIR levels in 100 paired tissues of EOC patients and corresponding normal tissues. Results showed that the expression level of HOTAIR in EOC tissues was significantly higher than that in corresponding normal tissues. Then the genotyping analyses of HOTAIR gene was conducted in a Chinese population. The results indicated that rs4759314 and rs7958904 were significantly associated with EOC susceptibility. For rs4759314, the difference between the G allele (as the reference) and the A allele was statistically significant (adjusted OR, 1.34; 95% CI: 1.08–1.65; P = 6.8 × 10–3). For rs7958904, C allele was associated a significantly decreased EOC risk when compared with G allele (OR: 0.77; 95% CI: 0.67–0.89; P = 4.2 × 10–4). The study identified that HOTAIR variants could be a useful biomarker for the predisposition to EOC and for the early diagnosis of the disease.


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