Research Papers:

Behavioral alterations following blood-brain barrier disruption stimulated by focused ultrasound

Feng-Yi Yang _, Sheng-Fang Huang and Irene Han-Juo Cheng

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Oncotarget. 2016; 7:27916-27925. https://doi.org/10.18632/oncotarget.8444

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Feng-Yi Yang1,2,3, Sheng-Fang Huang1, Irene Han-Juo Cheng4

1Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan

2Biophotonics and Molecular Imaging Research Center, National Yang-Ming University, Taipei, Taiwan

3Biomedical Engineering Research and Development Center, National Yang-Ming University, Taipei, Taiwan

4Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan

Correspondence to:

Feng-Yi Yang, e-mail: [email protected]

Keywords: focused ultrasound, behavioral alterations, blood-brain barrier, memory, anxiety

Received: February 22, 2016    Accepted: March 16, 2016    Published: March 28, 2016


The purpose of this study was to investigate the behavioral alterations and histological changes of the brain after FUS-induced BBB disruption (BBBD). Rats were behaviorally tested using the open field, hole-board, and grip strength tests from day 1 through day 32 after undergoing BBBD induced by FUS with either a mild or heavy parameter. In the open field test, we found an increase in center entries on day 1 and day 9 following heavy FUS treatment and a decrease in center entries at day 18 following mild FUS treatment. With regard to memory-related alterations, rats subjected to heavy FUS treatment exhibited longer latency to start exploring and to find the first baited hole. However, rats subjected to mild FUS treatment exhibited no significant differences in terms of memory performance or grip force. The obtained data suggest that heavy FUS treatment might induce hyperactivity, spatial memory impairment, and forelimb gripping deficits. Furthermore, while mild FUS treatment may have an impact on anxiety-related behaviors, the data suggested it had no impact on locomotor activity, memory, or grip force. Thus, the behavioral alterations following FUS-induced BBBD require further investigation before clinical application.

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