Research Papers: Gerotarget (Focus on Aging):

Olfactory phenotypic expression unveils human aging

Andrea Mazzatenta _, Alessandro Cellerino, Nicola Origlia, Davide Barloscio, Ferdinando Sartucci, Camillo Di Giulio and Luciano Domenici

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Oncotarget. 2016; 7:19193-19200. https://doi.org/10.18632/oncotarget.8393

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Andrea Mazzatenta1, Alessandro Cellerino2, Nicola Origlia3, Davide Barloscio3,4, Ferdinando Sartucci4, Camillo Di Giulio1 and Luciano Domenici3,5

1 Department of Neuroscience, Imaging and Clinical Science, ‘G. d’Annunzio’ University of Chieti-Pescara, Chieti, Italy

2 Scuola Normale Superiore, Pisa, Italy

3 Neuroscience Institute, CNR-Pisa, Pisa, Italy

4 Department di Medicina Clinica e Sperimentale, Sezione di Neurologia, e Dai di Neuroscienze, Pisa, Italy

5 Department of Applied Clinical Science and Biotechnology (DISCAB), School of Medicine, l’Aquila University, L’Aquila, Italy

Correspondence to:

Andrea Mazzatenta, email:

Keywords: aging, olfaction, olfactometry, absolute threshold, olfactory phenotype, Gerotarget

Received: January 27, 2016 Accepted: March 18, 2016 Published: March 26, 2016


The mechanism of the natural aging of olfaction and its declinein the absence of any overt disease conditions remains unclear. Here, we investigated this mechanism through measurement of one of the parameters of olfactory function, the absolute threshold, in a healthy population from childhood to old age. The absolute olfactory threshold data were collected from an Italian observational study with 622 participants aged 5-105 years. A subjective testing procedure of constant stimuli was used, which was also compared to the ‘staircase’ method, with the calculation of the reliability. The n-butanol stimulus was used as an ascending series of nine molar concentrations that were monitored using an electronic nose. The data were analyzed using nonparametric statistics because of the multimodal distribution. We show that the age-related variations in the absolute olfactory threshold are not continuous; instead, there are multiple olfactory phenotypes. Three distinct age-related phenotypes were defined, termed as ‘juvenile’, ‘mature’ and ‘elder’. The frequency of these three phenotypes depends on age. Our data suggest that the sense of smell does not decrease linearly with aging. Our findings provide the basis for further understanding of olfactory loss as an anticipatory sign of aging and neurodegenerative processes.

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